文献

J-GLOBAL ID：202102285932639823   整理番号：21A1471890

重症Covid-19の臨床経過と転帰: 国家規模研究【JST・京大機械翻訳】

Clinical Course and Outcomes of Severe Covid-19: A National Scale Study

著者 (52件)： Amit Moran (Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA) ,  Sorkin Alex (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Sorkin Alex (Department of Plastic and Reconstructive Surgery, Shamir Medical Centre, Zrifin 7033001, Israel) ,  Chen Jacob (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Chen Jacob (Medical Directorate, Ministry of Health, Jerusalem 9137001, Israel) ,  Cohen Barak (Division of Anesthesia, Intensive Care, and Pain Management, Tel-Aviv Medical Center, Tel-Aviv University, Tel-Aviv 6423906, Israel) ,  Cohen Barak (Outcomes Research Consortium, Cleveland Clinic, Cleveland, OH 44195, USA) ,  Karol Dana (Division of Anesthesia, Intensive Care, and Pain Management, Tel-Aviv Medical Center, Tel-Aviv University, Tel-Aviv 6423906, Israel) ,  Tsur Avishai M (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Tsur Avishai M (Department of Medicine ‘B’, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel) ,  Tsur Avishai M (Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel) ,  Lev Shaul (Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel) ,  Lev Shaul (Intensive Care, Hasharon Hospital, Rabin Medical Center, Petach Tikva 49372, Israel) ,  Rozenblat Tal (Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel) ,  Rozenblat Tal (Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center-Beilinson Hospital, Petach Tikva 49372, Israel) ,  Dvir Ayana (Intensive Care Unit, Shamir Medical Centre, Zrifin 7033001, Israel) ,  Landau Geva (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Landau Geva (Department of Plastic and Reconstructive Surgery, Shamir Medical Centre, Zrifin 7033001, Israel) ,  Fridrich Lidar (Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel) ,  Glassberg Elon (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Glassberg Elon (The Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA) ,  Glassberg Elon (The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 5290002, Israel) ,  Kesari Shani (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Kesari Shani (Department of Emergency Medicine, Assuta Ashdod University Hospital, Ashdod 7747629, Israel) ,  Sviri Sigal (Medical Intensive Care Unit, Hadassah-Hebrew University Medical Center Jerusalem 91120, Israel) ,  Gelman Ram (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Gelman Ram (Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel) ,  Miller Asaf (Medical Intensive Care Unit, Rambam Health Care Campus, Haifa 31096, Israel) ,  Epstein Danny (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Epstein Danny (Department of Internal Medicine “B”, Rambam Health Care Campus, Haifa 31096, Israel) ,  Ben-Avi Ronny (Thoracic Surgery Division, Poriya Medical Center, Tiberias 15208, Israel) ,  Ben-Avi Ronny (Covid-19 Intensive Care Unit, Poriya Medical Center, Tiberias 15208, Israel) ,  Matan Moshe (The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 5290002, Israel) ,  Matan Moshe (Covid-19 Intensive Care Unit, Poriya Medical Center, Tiberias 15208, Israel) ,  Jakobson Daniel J. (Intensive Care Unit, Barzilai University Medical Center, Ashkelon 78278, Israel) ,  Jakobson Daniel J. (Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba 84101, Israel) ,  Bader Tarif (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Bader Tarif (Department of Military Medicine, Hebrew University, Jerusalem 91120, Israel) ,  Dahan David (Respiratory & Medical (RM) Intensive Care Unit, Meir Medical Center, Kfar Saba 44821, Israel) ,  King Daniel A. (Respiratory & Medical (RM) Intensive Care Unit, Meir Medical Center, Kfar Saba 44821, Israel) ,  King Daniel A. (Pulmonary Department, Meir Medical Center, Kfar Saba 44821, Israel) ,  Ben-Ari Anat (Meir Medical Center, Kfar Sava 44821, Israel) ,  Soroksky Arie (Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel) ,  Soroksky Arie (Intensive Care Department, Wolfson MC, Holon 58100, Israel) ,  Bar Alon (Department of General Surgery, Kaplan Medical Center, Rehovot 76100, Israel) ,  Bar Alon (The Hebrew University of Jerusalem, Jerusalem 91120, Israel) ,  Fink Noam (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Fink Noam (Department of Military Medicine, Hebrew University, Jerusalem 91120, Israel) ,  Singer Pierre (Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel) ,  Singer Pierre (Department of General Intensive Care and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Petach Tikva 49100, Israel) ,  Benov Avi (Israel Defense Forces, Medical Corps, Tel Hasomer, Ramat Gan 01215, Israel) ,  Benov Avi (The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 5290002, Israel)
資料名： Journal of Clinical Medicine (Web)  (Journal of Clinical Medicine (Web))
巻： 9  号： 7  ページ： 2282  発行年： 2020年 
JST資料番号： U7214A  ISSN： 2077-0383  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 重症患者の転帰の知識は,地域発生に対処する方法を計画する健康と政府の公式にとって極めて重要である。集中治療室(ICU)で治療を必要とするコロナウイルス病2019(Covid-19)の重症患者の転帰に関連する因子は,まだ決定されていない。方法:これは,ICU入院のために参照され,イスラエルの13の参加センターのICUで治療された,実験室で確認されたSARS-CoV-2患者の遡及的登録ベースの症例シリーズであり,2020年3月5日と27月27日の間にイスラエルで治療された。臨床管理を含む人口統計学的および臨床データを収集し,多変量解析を行った。一次転帰は死亡率であった。【結果】本研究には,156人の患者(中央値=72歳(範囲=2297歳))が含まれた。69%(156の108)は男性であった。患者の89パーセント(156のうちの139)は,少なくとも1つの共存症があった。130人の患者(66%)は侵襲的機械的換気を必要とした。2020年5月8日,ICUにおける入院期間の中央値は10日(範囲=037日)であった。全体の死亡率は56%であった。多変量回帰モデルは,年齢増加(各年齢のOR=1.08,95%CI=1.031.13),敗血症の存在(各年齢のOR=1.08,95%CI=1.031.13),およびより短いICU滞在(各日のOR=0.90,95%CI=0.840.96)が独立予後因子であることを明らかにした。結論:著者らの症例シリーズにおいて,著者らは,消耗した健康システムにおけるそれらより低い死亡率を見つけた。著者らの多変数モデルの結果は,敗血症と二次感染の治療における抗ウイルス薬と抗菌剤のさらなる評価が必要であることを示唆する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 多変量解析 ,  換気 ,  抗ウイルス薬 ,  抗細菌薬 ,  死亡率 ,  敗血症 ,  *病状経過 ,  予後 ,  回帰モデル ,  ICU【医療】 ,  入院期間
準シソーラス用語： 2次感染 ,  重症患者 ,  予後因子 ,  患者予後 , 【Automatic Indexing@JST】

著者キーワード (6件)： コビッド-19 ,  ICU ,  ARDS ,  共存症 ,  予後 ,  死亡率

分類 (2件)： 消化器の疾患  (GH03000W) ,  感染症・寄生虫症一般  (GD01010H)

引用文献 (17件)：

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• Richardson, S.; Hirsch, J.S.; Narasimhan, M.; Crawford, J.M.; McGinn, T.; Davidson, K.W.; Barnaby, D.P.; Becker, L.B.; Chelico, J.D.; Cohen, S.L.; et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA 2020, 323, 2052.
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タイトルに関連する用語 (6件)： 重症 ,  臨床経過 ,  転帰 ,  国家 ,  規模 ,  研究