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J-GLOBAL ID：202102291653834508   整理番号：21A0158949

COVID-19患者におけるQingfei Paidu煎剤の早期治療と良好な臨床転帰との関連性: 後向き多施設コホート研究【JST・京大機械翻訳】

Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study

著者 (92件)： Shi Nannan (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Liu Bin (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Liang Ning (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Ma Yan (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Ge Youwen (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Yi Honggang (School of Public Health, Nanjing Medical University, Nanjing, China) ,  Wo Hongmei (School of Health Policy and Management, Nanjing Medical University, Nanjing, China) ,  Gu Heng (School of Public Health, Nanjing Medical University, Nanjing, China) ,  Kuang Yuan (School of Public Health, Nanjing Medical University, Nanjing, China) ,  Tang Shaowen (School of Public Health, Nanjing Medical University, Nanjing, China) ,  Zhao Yang (School of Public Health, Nanjing Medical University, Nanjing, China) ,  Tong Lin (Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Liu Sihong (Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Zhao Chen (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Chen Renbo (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Bai Weiguo (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Fan Yipin (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Shi Zhan (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Li Li (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Liu Jia (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Gu Hao (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Zhi Yingjie (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Wang Zhifei (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Li Yuanyuan (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Li Huizhen (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Wang Jingya (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Jiao Liwen (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Tian Yaxin (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Xiong Yibai (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Huo Ruili (China Academy of Chinese Medical Sciences, Beijing, China) ,  Zhang Xiaohui (Institute of Medical Information, Chinese Academy of Medical Science, Beijing, China) ,  Bai Jiangfeng (Department of Infectious Disease, Yulin Chinese Medicine Hospital, Shaanxi, China) ,  Chen Hong (President’s Office, The First Hospital of Qiqiha, Heilongjiang, China) ,  Chen Liying (Department of Traditional Chinese Medicine, Shangluo Central Hospital, Shaanxi, China) ,  Feng Qiao (Department of Traditional Chinese Medicine, The People’s Hospital of QiTaiHe, Heilongjiang, China) ,  Guo Tuanmao (Department of Scientific Research, Xianyang Central Hospital, Shaanxi, China) ,  Hou Yong (The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Anhui, China) ,  Hu Guifen (Department of Infectious Disease, HePing Hospital Affiliated to ChangZhi Medical College, Shanxi, China) ,  Hu Xiaomei (Department of Traditional Chinese Medicine, Langfang Hospital of Chinese Medicine, Hebei, China) ,  Hu Yunhong (Department of Traditional Chinese Medicine, Xingtai Hospital of Chinese Medicine, Hebei, China) ,  Huang Jin (Department of Traditional Chinese Medicine, The People’s Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China) ,  Huang Qiuhua (Department of Traditional Chinese Medicine, The People’s Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China) ,  Huang Shaozhen (Department of Traditional Chinese Medicine, The First People’s Hospital of Fangchenggang, Guangxi, China) ,  Ji Liang (Department of Traditional Chinese Medicine, Mianyang Hospital of Traditional Chinese Medicine, Sichuan, China) ,  Jin Haihao (Department of Traditional Chinese Medicine, Liuzhou People’s Hospital, Guangxi, China) ,  Lei Xiao (Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Sichuan, China) ,  Li Chunyan (Department of Infectious Disease, Yan’an Second People’s Hospital, Shaanxi, China) ,  Wu Guihui (Department of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China) ,  Li Jike (Department of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China) ,  Li Minqing (Department of Traditional Chinese Medicine, Dazhou Central Hospital, Sichuan, China) ,  Li Quntang (Chongqing Traditional Chinese Medicine Hospital, Chongqing, China) ,  Li Xianyong (The Second People’s Hospital of Neijiang, Sichuan, China) ,  Liu Hongde (Shijiazhuang Fifth Hospital, Hebei, China) ,  Liu Jinping (Department of Infectious Disease, The Fourth People’s Hospital of Taiyuan, Shanxi, China) ,  Liu Zhang (Department of Traditional Chinese Medicine, The First Hospital of Suihua City, Heilongjiang, China) ,  Ma Yuting (Department of Traditional Chinese Medicine, The Fourth People’s Hospital of Nanning, Guangxi, China) ,  Mao Ya (Department of Infectious Disease, Ankang Hospital of Traditional Chinese Medicine, Shaanxi, China) ,  Mo Liufen (Beihai Hospital of Chinese Medicine, Guangxi, China) ,  Na Hui (Department of Infectious Disease, Harbin Infectious Disease Hospital, Heilongjiang, China) ,  Wang Jingwei (Department of Infectious Disease, Harbin Infectious Disease Hospital, Heilongjiang, China) ,  Song Fangli (Department of Infectious Disease, The Third People’s Hospital of Linfen, Shanxi, China) ,  Sun Sheng (Department of Traditional Chinese Medicine, Chengde Hospital of Traditional Chinese Medicine, Hebei, China) ,  Wang Dongting (Department of Infectious Disease, Datong Fourth Hospital, Shanxi, China) ,  Wang Mingxuan (Department of Traditional Chinese Medicine, Suining Central Hospital, Sichuan, China) ,  Wang Xiaoyan (Department of Infectious Disease, Jinzhong Infectious Disease Hospital, Shanxi, China) ,  Wang Yinzhen (Department of Infectious Disease, Jincheng People’s Hospital, Shanxi, China) ,  Wang Yudong (Hengshui Hospital of Chinese Medicine, Hebei, China) ,  Wu Wei (President’s Office, Hanzhong Central Hospital, Shaanxi, China) ,  Wu Lanping (Department of Infectious Disease, Shuozhou People’s Hospital, Shanxi, China) ,  Xiao Yanhua (Department of Traditional Chinese Medicine, Mudanjiang Kangan Hospital, Heilongjiang, China) ,  Xie Haijun (Department of Infectious Disease, Xinzhou People’s Hospital, Shanxi, China) ,  Xu Hongming (Department of Infectious Disease, Daqing Second Hospital, Heilongjiang, China) ,  Xu Shoufang (Jiamusi Infectious Disease Hospital, Heilongjiang, China) ,  Xue Ruixia (Department of Infectious Disease, Yuncheng Second Hospital, Shanxi, China) ,  Yang Chun (Department of Traditional Chinese Medicine, Hanzhong Hospital for Infectious Diseases, Shaanxi, China) ,  Yang Kaijun (Department of Medical Administration, The Third People’s Hospital of Yangquan, Shanxi, China) ,  Yang Puye (Department of Infectious Disease, Shaanxi Infectious Disease Hospital, Shaanxi, China) ,  Yuan Shengli (Department of Traditional Chinese Medicine, Zhangjiakou Hospital of Traditional Chinese Medicine, Hebei, China) ,  Zhang Gongqi (Department of Traditional Chinese Medicine, Baoji Central Hospital, Shaanxi, China) ,  Zhang Jinbo (Department of Infectious Disease, Xi’an Chest Hospital, Shaanxi, China) ,  Zhang Linsong (Department of Traditional Chinese Medicine, Hospital (T・C・M) Affiliated to Southwest Medical University, Sichuan, China) ,  Zhao Shusen (Qiqihar Institute for The Prevention and Treatment of Infectious Diseases, Heilongjiang, China) ,  Zhao Wanying (Hegang Infectious Hospital, Heilongjiang, China) ,  Zheng Kai (Fenyang Hospital of Shanxi Province, Shanxi, China) ,  Zhou Yingchun (Department of Infectious Disease, Shuangyashan People’s Hospital, Heilongjiang, China) ,  Zhu Junteng (Department of Rehabilitation Medicine, The Affiliated Hospital of Putian College, Fujian, China) ,  Zhu Tianqing (Department of Infectious Disease, The Greater Khingan Range People’s Hospital, Heilongjiang, China) ,  Li Guangxi (Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China) ,  Wang Wei ,  Zhang Huamin ,  Wang Yanping (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China) ,  Wang Yongyan (Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China)
資料名： Pharmacological Research  (Pharmacological Research)
巻： 161  ページ： Null  発行年： 2020年 
JST資料番号： E0326B  ISSN： 1043-6618  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： コロナウイルス病2019(COVID-19)流行は,「早期診断と早期治療」を含む一連の政策の下で,中国でほとんど制御されてきた。本研究は,Qingfei Paidu煎剤(QFPDD)による早期治療と良好な臨床転帰との関連を調査することを目的とした。この後向き多施設研究において,著者らは,中国の9つの行政区における54の病院から確認されたCOVID-19を有する782人の患者(男性,56%;中央値46歳)を含んで,それは,QFPDDによる開始治療の開始の最初の日から治療開始までの時間によって,治療開始時間によって4つの群に分けた。一次転帰は回復までの時間であった。ウイルス脱落の日数,入院期間,および疾患の経過も分析した。3週後に開始した治療と比較して,1週未満のQFPDDによる早期治療,1~2週,または2~3週は,それぞれ3.81(2.65~5.48),2.63(1.86~3.73),および1.92(1.34~2.75)の調整されたハザード比(HR)(95%信頼区間[CI])で,回復のより高い尤度を有した。治療を週初期に投与すると,疾患の中央値は34日から24日,21日および18日に減少した(P<0.0001)。1週間以内の治療は,後期治療(P<0.0001)と比較して入院期間の中央値で1~4日の減少と関係した。結論として,QFPDDによる早期治療は,QFPDDによる早期治療が,より迅速な回復,ウイルス放出までの時間の短縮,および入院期間の短い期間を含む良好な転帰と関連していたため,流行を制御する効果的な戦略として役立つ可能性がある。しかし,QFPDDによる早期治療の利点を確認するために,より大きなサンプルサイズを有する更なる多施設前向き研究を行うべきである。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 男性 ,  早期診断 ,  *煎剤 ,  入院期間 ,  コホート研究 ,  前向きコホート研究
準シソーラス用語： コロナウイルス ,  *早期治療 ,  尤度 ,  ハザード比 , 【Automatic Indexing@JST】

著者キーワード (3件)： COVID-19 ,  Qingfei Paidu煎剤 ,  早期治療

分類 (2件)： 血液の腫よう  (GK04000M) ,  抗腫よう薬の臨床への応用  (GW16020L)

タイトルに関連する用語 (8件)： 患者 ,  煎剤 ,  早期治療 ,  臨床転帰 ,  関連性 ,  施設 ,  コホート ,  研究