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J-GLOBAL ID：202102297723913301   整理番号：21A2231012

PANSSによる統合失調症患者における心理機能のモデリング:国際多施設研究【JST・京大機械翻訳】

Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study

著者 (107件)： Fountoulakis Konstantinos N. ( 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Dragioti Elena ( Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linkoping University, Linkoping, Sweden) ,  Dragioti Elena ( Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden) ,  Theofilidis Antonis T. ( 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Wiklund Tobias ( Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linkoping University, Linkoping, Sweden) ,  Wiklund Tobias ( Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden) ,  Atmatzidis Xenofon ( Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linkoping University, Linkoping, Sweden) ,  Atmatzidis Xenofon ( Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden) ,  Nimatoudis Ioannis ( 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Thys Erik ( University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium) ,  Wampers Martien ( University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium) ,  Wampers Martien ( Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium) ,  Hranov Luchezar ( University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry ”Sveti Naum”, Sofia, Bulgaria) ,  Hristova Trayana ( University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry ”Sveti Naum”, Sofia, Bulgaria) ,  Aptalidis Daniil ( University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry ”Sveti Naum”, Sofia, Bulgaria) ,  Milev Roumen ( Department of Psychiatry, Queen’s University, Providence Care Hospital, Kingston, Ontario, Canada) ,  Iftene Felicia ( Department of Psychiatry, Queen’s University, Providence Care Hospital, Kingston, Ontario, Canada) ,  Spaniel Filip ( National Institute of Mental Health, Klecany, Czech Republic) ,  Knytl Pavel ( National Institute of Mental Health, Klecany, Czech Republic) ,  Furstova Petra ( National Institute of Mental Health, Klecany, Czech Republic) ,  From Tiina ( Department of Psychiatry, University of Turku, Turku, Finland) ,  Karlsson Henry ( Department of Psychiatry, University of Turku, Turku, Finland) ,  Walta Maija ( Department of Psychiatry, University of Turku, Turku, Finland) ,  Salokangas Raimo K.R. ( Department of Psychiatry, University of Turku, Turku, Finland) ,  Azorin Jean-Michel ( Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France) ,  Azorin Jean-Michel ( Timone Institute of Neuroscience, Marseille, France) ,  Bouniard Justine ( Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France) ,  Bouniard Justine ( Timone Institute of Neuroscience, Marseille, France) ,  Montant Julie ( Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France) ,  Montant Julie ( Timone Institute of Neuroscience, Marseille, France) ,  Juckel Georg ( Department of Psychiatry, Ruhr University Bochum, Bochum, Germany) ,  Haussleiter Ida S. ( Department of Psychiatry, Ruhr University Bochum, Bochum, Germany) ,  Douzenis Athanasios ( 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece) ,  Michopoulos Ioannis ( 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece) ,  Ferentinos Panagiotis ( 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece) ,  Smyrnis Nikolaos ( Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece) ,  Mantonakis Leonidas ( Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece) ,  Nemes Zsofia ( Nyiroe Gyula Hospital, Budapest, Hungary) ,  Gonda Xenia ( Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary) ,  Vajda Dora ( Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary) ,  Juhasz Anita ( Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary) ,  Shrivastava Amresh ( Western University, London, Ontario, Canada) ,  Waddington John ( Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland) ,  Pompili Maurizio ( Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy) ,  Comparelli Anna ( Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy) ,  Corigliano Valentina ( Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy) ,  Rancans Elmars ( Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia) ,  Navickas Alvydas ( Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania) ,  Navickas Alvydas ( Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Navickas Alvydas ( Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Hilbig Jan ( Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania) ,  Hilbig Jan ( Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Hilbig Jan ( Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Bukelskis Laurynas ( Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania) ,  Bukelskis Laurynas ( Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Bukelskis Laurynas ( Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania) ,  Stevovic Lidija I. ( Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro) ,  Stevovic Lidija I. ( Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro) ,  Stevovic Lidija I. ( Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro) ,  Vodopic Sanja ( Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro) ,  Vodopic Sanja ( Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro) ,  Vodopic Sanja ( Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro) ,  Esan Oluyomi ( Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria) ,  Oladele Oluremi ( Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria) ,  Osunbote Christopher ( Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria) ,  Rybakowski Janusz K. ( Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland) ,  Wojciak Pawel ( Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland) ,  Domowicz Klaudia ( Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland) ,  Figueira Maria L. ( Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal) ,  Linhares Ludgero ( Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal) ,  Crawford Joana ( Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal) ,  Panfil Anca-Livia ( University of Medicine and Pharmacy of Targu Mures, Targu Mures, Romania) ,  Smirnova Daria ( Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russia) ,  Izmailova Olga ( Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russia) ,  Lecic-Tosevski Dusica ( Institute of Mental Health, Belgrade, Serbia) ,  Lecic-Tosevski Dusica ( Serbian Academy of Sciences and Arts, Belgrade, Serbia) ,  Temmingh Henk ( Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa) ,  Howells Fleur ( Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa) ,  Bobes Julio ( Department of Psychiatry, University of Oviedo and Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Oviedo, Spain) ,  Garcia-Portilla Maria P. ( Department of Psychiatry, University of Oviedo and Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Oviedo, Spain) ,  Garcia-Alvarez Leticia ( Department of Psychiatry, University of Oviedo and Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Oviedo, Spain) ,  Erzin Gamze ( Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey) ,  Karadag Hasan ( Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey) ,  De Sousa Avinash ( Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India) ,  Bendre Anuja ( Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India) ,  Hoschl Cyril ( National Institute of Mental Health, Klecany, Czech Republic) ,  Bredicean Cristina ( University of Medicine and Pharmacy of Timisoara, Timisoara, Romania) ,  Papava Ion ( University of Medicine and Pharmacy of Timisoara, Timisoara, Romania) ,  Vukovic Olivera ( Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia) ,  Pejuskovic Bojana ( Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland) ,  Russell Vincent ( Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland) ,  Athanasiadis Loukas ( 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Konsta Anastasia ( 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece) ,  Stein Dan ( MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa) ,  Berk Michael ( IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia) ,  Berk Michael ( Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia) ,  Berk Michael ( Centre for Youth Mental Health, The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia) ,  Berk Michael ( Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia) ,  Dean Olivia ( IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia) ,  Dean Olivia ( Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia) ,  Dean Olivia ( Centre for Youth Mental Health, The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia) ,  Dean Olivia ( Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia) ,  Tandon Rajiv ( Department of Psychiatry, University of Florida, Gainesville, Florida, USA) ,  Kasper Siegfried ( Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria) ,  De Hert Marc ( University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium) ,  De Hert Marc ( Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium) ,  De Hert Marc ( Antwerp Health Law and Ethics Chair-AHLEC University, Antwerpen, Belgium)
資料名： CNS Spectrums  (CNS Spectrums)
巻： 26  号： 3  ページ： 290-298  発行年： 2020年 
JST資料番号： W5455A  ISSN： 1092-8529  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 背景:本研究の目的は,包括的で意味のある疾患モデルを組み立てるために,統合失調症の段階を通して臨床変数間の相互関係の変化を調査することであった。方法:25か国からの29のセンターが参加し,統合失調症の37.21±11.87歳の2358人の患者を含んだ。プロットの多重線形回帰分析と目視検査を行った。結果:結果は,進行ステージで,各ステージで陽性と陰性症候群スケール因子の間に変化相関があり,各因子は,この因子が支配的である特定のステージで,他のすべてのものと相関することを示唆する。この内部構造は,既に提案された4つの段階モデルの妥当性を支持し,第1段階を支配する陽性症状,第2の興奮/敵対性,第3の鬱病,および神経認知は最後の段階を減退する。結論:この研究は,疾患進行の異なる段階と関係した統合失調症患者における精神組織および機能を検討した。それは,統合失調症の2つの明確な「コア」,”Positive”と”Negative”を明らかにし,一方,神経認知低下が後期段階の間にエスカレートを縮小した。将来の研究は,そのようなモデルの治療効果に焦点を当てるべきである。病気の進行を止めることは,ステージの継承を止めることを要求する。これは,陽性および陰性症状の誘発効果の停止だけでなく,神経認知に関与する神経ネットワークに対する有害な効果と同様に,宿主性,興奮,不安およびうつ病の発症に関与する神経経路に対する感作効果を停止することの両方によって達成される。Please refer to the publisher for the copyright holders. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 感作 ,  興奮 ,  *統合失調症 ,  うつ病 ,  内部構造 ,  病態モデル ,  スケール因子 ,  肉眼検査
準シソーラス用語： 疾患進行 ,  認知障害 ,  神経ネットワーク ,  陰性症状 ,  陽性症状 , 【Automatic Indexing@JST】

著者キーワード (5件)： 統合失調症 ,  モデル ,  病期分類 ,  長期コース ,  転帰

分類 (4件)： 精神障害の診断  (GR02000T) ,  分子遺伝学一般  (EC02010J) ,  代謝異常・栄養性疾患一般  (GD05010J) ,  精神障害  (GR03000A)

タイトルに関連する用語 (6件)： PANSS ,  統合失調症患者 ,  心理 ,  モデリング ,  施設 ,  研究