Chai C. Gopalasingam, Haruka Egami, Hideki Shigematsu, Masatora Sakaue, Kouki Fukumoto, Christoph Gerle, Masaki Yamamoto, Yoshitsugu Shiro, Kazumasa Muramoto, Takehiko Tosha. Structural basis of Neisseria meningitidis quinol dependent nitric oxide reductase activation by dimerization. Communications Biology. 2026
Keishiro Uda, Takeshi Yamagami, Sonoko Ishino, Christoph Gerle, Chai C. Gopalasingam, Hideki Shigematsu, Tomoyuki Numata, Yoshizumi Ishino. Substrate specificity and action mechanism of the HerA-NurA nuclease from the hyperthermophilic archaeon Thermococcus kodakarensis. mBio. 2026
Kazuki Ishihara, Shunsuke Matsumoto, Christoph Gerle, Chai C Gopalasingam, Hideki Shigematsu, Tsuyoshi Shirai, Tomoyuki Numata. Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition. Nucleic Acids Research. 2026. 54. 1
Nariyoshi Umekubo, Airi Hashizume, Haruki Saito, Satoru Kato, Chisato Kanai, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Atsushi Yoshimori, Kazuhiro Abe, et al. Design, synthesis, and structural analysis of an inhibitor of the gastric proton pump with a diaza-tricyclic skeleton. Organic & Biomolecular Chemistry. 2026
Yuheng Qian, Chai C. Gopalasingam, Christoph Gerle, Hideki Shigematsu, Kazuhiro Abe, Atsunori Oshima. Cryo-EM structure of the ATP11C Q79E mutant reveals the structural basis for altered Phospholipid recognition. Journal of Biological Chemistry. 2026