研究者
J-GLOBAL ID：202201018948246977   更新日: 2024年08月05日

大畑 広和

Ohata Hirokazu
競争的資金等の研究課題 (4件)：
  • 2023 - 2026 抗がん剤抵抗性を示す休止型大腸がん幹細胞を標的にした治療戦略の構築
  • 2020 - 2023 オートファジーによる静止期大腸がん幹細胞の維持機構の解明
  • 2016 - 2018 大腸がん幹細胞性制御カリウムチャネルの同定
  • 2012 - 2014 ヒト大腸がん幹細胞の継代培養系における腫瘍形成能維持のメカニズムの解明
論文 (25件)：
  • Yutaro Mori, Yoshie Okimoto, Hiroaki Sakai, Yusuke Kanda, Hirokazu Ohata, Daisuke Shiokawa, Mikiko Suzuki, Hiroshi Yoshida, Haruka Ueda, Tomoyuki Sekizuka, et al. Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer. Cell Reports Medicine. 2024. 101532-101532
  • Daisuke Shiokawa, Hiroaki Sakai, Miho Koizumi, Yoshie Okimoto, Yutaro Mori, Yusuke Kanda, Hirokazu Ohata, Hiroaki Honda, Koji Okamoto. Elevated stress response marks deeply quiescent reserve cells of gastric chief cells. Communications biology. 2023. 6. 1. 1183-1183
  • Hirokazu Ohata, Daisuke Shiokawa, Hiroaki Sakai, Yusuke Kanda, Yoshie Okimoto, Syuzo Kaneko, Ryuji Hamamoto, Hitoshi Nakagama, Koji Okamoto. PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway. Cell reports. 2023. 42. 6. 112519-112519
  • Toshiaki Miyazaki, Suyoun Chung, Hiroaki Sakai, Hirokazu Ohata, Yuuki Obata, Daisuke Shiokawa, Yukihiro Mizoguchi, Takashi Kubo, Hitoshi Ichikawa, Hirokazu Taniguchi, et al. Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. Cancer science. 2022. 113. 1. 170-181
  • Yusuke Kanda, Hirokazu Ohata, Toshiaki Miyazaki, Hiroaki Sakai, Yutaro Mori, Daisuke Shiokawa, Akira Yokoi, Takashi Owa, Atsushi Ochiai, Koji Okamoto. NF-κB suppression synergizes with E7386, an inhibitor of CBP/β-catenin interaction, to block proliferation of patient-derived colon cancer spheroids. Biochemical and biophysical research communications. 2022. 586. 93-99
もっと見る
MISC (1件)：
  • Tatsuya Ishiguro, Hirokazu Ohata, Hitoshi Nakagama, Koji Okamoto, Kenichi Tanaka, Takayuki Enomoto. Human ovarian cancer stem cells: In vitro cultivation and characterization. CANCER RESEARCH. 2014. 74. 19
※　J-GLOBALの研究者情報は、researchmapの登録情報に基づき表示しています。 登録・更新については、こちらをご覧ください。

前のページに戻る

TOP

BOTTOM