2024 - 2024 二倍体細胞におけるBITRExの検討:interchromatid vs. interhomolog BIR
2023 - 2024 変異誘導条件下の縦列反復伸長による多重遺伝子族創成への挑戦
2023 - 2023 Cas9ニッケースの複数遺伝子座への同時誘導による高度な遺伝子増幅系の構築
2022 - 2022 Cas9ニッケースを用いた新手法によって遺伝子の安定な高発現系を構築する
論文 (8件):
Hiroaki Takesue, Satoshi Okada, Goro Doi, Yuki Sugiyama, Emiko Kusumoto, and Takashi Ito. Strategic targeting of Cas9 nickase expands tandem gene arrays. bioRxiv. 2024
Hisako Takigawa-Imamura, Katsumi Fumoto, Hiroaki Takesue, Takashi Miura. Exploiting mechanisms for hierarchical branching structure of lung airway. PLoS ONE. 2024
Okura, Y., Ikawa-Teranishi, Y., Mizoroki, A., Takahashi, N., Tsushima, T., et al. Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease. Nature communications. 2023
Yuki Noguchi, Kazuhisa Ozeki, Hiroaki Takesue, Hidetaka Akita. A cell based assay for evaluating binding and uptake of an antibody using hepatic nonparenchymal cells. Scientific Reports. 2021
Genki Nakamura, Kazuhisa Ozeki, Hiroaki Takesue, Mitsuyasu Tabo, Ken-ichi Hosoya. Prediction of Human Pharmacokinetics Profile of Monoclonal Antibody Using hFcRn Transgenic Mouse Model. Biological and Pharmaceutical Bulletin. 2021. 44. 3. 389-395
Takeshi Hirota, Toshihiro Tanaka, Hiroaki Takesue, Ichiro Ieiri. Epigenetic regulation of drug transporter expression in human tissues. Expert Opinion on Drug Metabolism and Toxicology. 2017