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J-GLOBAL ID：202202210080567388   整理番号：22A0480919

SARS-CoV-2βに対する抗体応答は他の変異体への抗原距離を強調する【JST・京大機械翻訳】

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

著者 (49件)： Liu Chang (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Chang (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Zhou Daming (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Zhou Daming (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Nutalai Rungtiwa (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Duyvesteyn Helen M.E. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Tuekprakhon Aekkachai (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Ginn Helen M. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Dejnirattisai Wanwisa (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Supasa Piyada (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mentzer Alexander J. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mentzer Alexander J. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Wang Beibei (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Case James Brett (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Zhao Yuguang (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Skelly Donal T. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Skelly Donal T. (Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Skelly Donal T. (Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK) ,  Chen Rita E. (Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Chen Rita E. (Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Johnson Sile Ann (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Johnson Sile Ann (Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Ritter Thomas G. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Mason Chris (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Malik Tariq (National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK) ,  Temperton Nigel (Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and Greenwich, Chatham Maritime, Kent ME4 4TB, UK) ,  Paterson Neil G. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Williams Mark A. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Hall David R. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Clare Daniel K. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Howe Andrew (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Goulder Philip J.R. (Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Goulder Philip J.R. (Department of Paediatrics, University of Oxford, Oxford, UK) ,  Fry Elizabeth E. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Diamond Michael S. (Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Diamond Michael S. (Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Diamond Michael S. (Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Diamond Michael S. (The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA) ,  Mongkolsapaya Juthathip (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand) ,  Ren Jingshan (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Stuart David I. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Stuart David I. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Stuart David I. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Stuart David I. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Stuart David I. (Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK) ,  Screaton Gavin R. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Screaton Gavin R. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK)
資料名： Cell Host & Microbe  (Cell Host & Microbe)
巻： 30  号： 1  ページ： 53-68.e12  発行年： 2022年 
JST資料番号： W2784A  ISSN： 1931-3128  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： SARS-CoV-2のα-B.1.1.7,β-B.1.351,ガンマ-P.1およびDelta-B.1.617.2変異体は,スパイク蛋白質(S)において複数の変異を発現する。これらはSの抗原構造を変化させ,自然またはワクチン誘導免疫からの脱出を引き起こす。ベータは,初期パンデミックSARS-CoV-2株により誘導される血清を用いて中和するのが特に困難であり,デルタから最も抗原的に分離される。これを理解するために,Beta感染個体から674のmAbsを作成し,27の最も強力なmAbsの詳細な構造-機能解析を行った:1つはスパイクN末端ドメイン(NTD),残りの受容体結合ドメイン(RBD)を結合させた。これらRBD結合mAbsの2つは,SARS-CoV-1と-2の間に保存された中和エピトープを認識し,一方,β:K417N,E484K,およびN501Yにおける18の標的変異残基を同定した。また,E484KとK417Nを標的とする,一般のIgVH4-39配列を含むN501Yに対する主要な応答がある。これらの重要な残基の認識は,Beta症例からの血清が早期のパンデミックとデルタウイルスをあまり中和しない理由を強調する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 血清 ,  *抗原 ,  *抗体 ,  受容体 ,  免疫反応 ,  ワクチン ,  結合部位 ,  機能分析 ,  エピトープ ,  フダンソウ属 ,  中性化
準シソーラス用語： *SARSウイルス ,  *重症急性呼吸器症候群 ,  スパイク蛋白質 ,  残基 , 【Automatic Indexing@JST】

著者キーワード (10件)： SARS-CoV-2 ,  COVID-19 ,  ベータ変異体 ,  免疫応答 ,  スパイク蛋白質 ,  抗体 ,  受容体結合ドメイン ,  構造 ,  ワクチン ,  中性化

分類 (2件)： 抗原・抗体・補体の生化学  (ED04020L) ,  免疫療法薬・血液製剤の基礎研究  (GW22010D)

タイトルに関連する用語 (5件)： SARS-CoV-2 ,  抗体 ,  応答 ,  変異体 ,  抗原