文献

J-GLOBAL ID：202202211301706824   整理番号：22A0681545

SARS-CoV-2 Omicron-B.1.1.529は中和抗体応答から広範囲の逃避を導く【JST・京大機械翻訳】

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

著者 (108件)： Dejnirattisai Wanwisa (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Huo Jiandong (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Zhou Daming (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Zhou Daming (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Zahradnik Jiri (Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Supasa Piyada (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Chang (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Chang (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Duyvesteyn Helen M.E. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Ginn Helen M. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Mentzer Alexander J. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mentzer Alexander J. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Tuekprakhon Aekkachai (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Nutalai Rungtiwa (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Wang Beibei (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dijokaite Aiste (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Khan Suman (Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Avinoam Ori (Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Bahar Mohammad (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Skelly Donal (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Skelly Donal (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Skelly Donal (Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK) ,  Adele Sandra (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Johnson Sile Ann (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Amini Ali (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Amini Ali (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Amini Ali (Translational Gastroenterology Unit, University of Oxford, Oxford, UK) ,  Ritter Thomas G. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Mason Chris (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Dold Christina (NIHR Oxford Biomedical Research Centre, Oxford, UK) ,  Dold Christina (Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK) ,  Pan Daniel (Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK) ,  Pan Daniel (Department of Respiratory Sciences, University of Leicester, Leicester, UK) ,  Assadi Sara (Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK) ,  Bellass Adam (Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK) ,  Omo-Dare Nicola (Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK) ,  Koeckerling David (Medical Sciences Division, University of Oxford, Oxford, UK) ,  Flaxman Amy (Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Jenkin Daniel (Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Aley Parvinder K. (Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK) ,  Voysey Merryn (Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK) ,  Costa Clemens Sue Ann (Institute of Global Health, University of Siena, Siena, Brazil) ,  Costa Clemens Sue Ann (Department of Paediatrics, University of Oxford, Oxford, UK) ,  Naveca Felipe Gomes (Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia, Instituto Leonidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil) ,  Nascimento Valdinete (Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia, Instituto Leonidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil) ,  Nascimento Fernanda (Laboratorio de Ecologia de Doencas Transmissiveis na Amazonia, Instituto Leonidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil) ,  Fernandes da Costa Cristiano (Fundacao de Vigilancia em Saude do Amazonas, Manaus, Amazonas, Brazil) ,  Resende Paola Cristina (Laboratorio de virus respiratorios-IOC/FIOCRUZ, Rio de Janeiro, Brazil) ,  Pauvolid-Correa Alex (Laboratorio de virus respiratorios-IOC/FIOCRUZ, Rio de Janeiro, Brazil) ,  Pauvolid-Correa Alex (Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA) ,  Siqueira Marilda M. (Laboratorio de virus respiratorios-IOC/FIOCRUZ, Rio de Janeiro, Brazil) ,  Baillie Vicky (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Baillie Vicky (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Serafin Natali (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Serafin Natali (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Kwatra Gaurav (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Kwatra Gaurav (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Da Silva Kelly (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Da Silva Kelly (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Madhi Shabir A. (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Madhi Shabir A. (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Nunes Marta C. (South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Nunes Marta C. (Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa) ,  Malik Tariq (National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK) ,  Openshaw Peter J.M. (National Heart & Lung Institute, Imperial College, London, UK) ,  Baillie J. Kenneth (Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK) ,  Semple Malcolm G. (NIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK) ,  Townsend Alain R. (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Townsend Alain R. (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK) ,  Huang Kuan-Ying A. (Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital and Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan) ,  Tan Tiong Kit (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK) ,  Carroll Miles W. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Carroll Miles W. (National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK) ,  Klenerman Paul (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Klenerman Paul (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Klenerman Paul (Translational Gastroenterology Unit, University of Oxford, Oxford, UK) ,  Klenerman Paul (NIHR Oxford Biomedical Research Centre, Oxford, UK) ,  Barnes Eleanor (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Barnes Eleanor (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Barnes Eleanor (Translational Gastroenterology Unit, University of Oxford, Oxford, UK) ,  Barnes Eleanor (NIHR Oxford Biomedical Research Centre, Oxford, UK) ,  Dunachie Susanna J. (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) ,  Dunachie Susanna J. (Peter Medawar Building for Pathogen Research, Oxford, UK) ,  Dunachie Susanna J. (Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dunachie Susanna J. (Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand) ,  Dunachie Susanna J. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Constantinides Bede (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Webster Hermione (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Crook Derrick (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Pollard Andrew J. (NIHR Oxford Biomedical Research Centre, Oxford, UK) ,  Pollard Andrew J. (Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK) ,  Lambe Teresa (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Lambe Teresa (Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK) ,  Paterson Neil G. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Williams Mark A. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Hall David R. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Fry Elizabeth E. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Mongkolsapaya Juthathip (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand) ,  Ren Jingshan (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Schreiber Gideon (Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Stuart David I. (Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK) ,  Stuart David I. (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK) ,  Stuart David I. (Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK) ,  Stuart David I. (Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK) ,  Screaton Gavin R. (Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Screaton Gavin R. (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 185  号： 3  ページ： 467-484.e15  発行年： 2022年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 24th11月2021日に,新規SARS-CoV-2ウイルス分離株Omicron-B.1.1.529の配列が発表され,以前報告された変異体よりSpike(S)のはるかに多くの変異を含んだ。ワクチンからの血清によるOmicronの中和力価および早期パンデミックアルファ,ベータ,ガンマまたはデルタに感染した回復性被験者は実質的に減少し,血清は中和できなかった。Omicronに対する力価は第3のワクチン用量によって促進され,ワクチン接種された個人とデルタによって感染されたそれらの両方で高い。Omicronノックアウトの変異は,市販開発中の強力なモノクローナル抗体と抗体の多くのパネルによって中和を実質的に低減または実質的に減少させる。ミクロンSは,初期のウイルスから構造変化を有し,免疫回避により駆動される非洗浄進化にACE2に強固な結合を与える変異を使用する。これはACE2結合部位における多数の変異をもたらし,以前のパンデミックウイルスに対する受容体親和性を再バランスさせる。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 血清 ,  *抗体 ,  受容体 ,  免疫反応 ,  ワクチン ,  結合部位 ,  親和性 ,  予防接種 ,  ロバスト性 ,  モノクローナル抗体 ,  *中性化 ,  *中和抗体
準シソーラス用語： *重症急性呼吸器症候群 ,  アンギオテンシン変換酵素2 ,  免疫回避 ,  ウイルス分離 , 【Automatic Indexing@JST】

著者キーワード (8件)： SARS-CoV-2 ,  Omicron ,  変異体 ,  ワクチン ,  免疫回避 ,  受容体相互作用 ,  スパイク ,  RBD

分類 (3件)： 感染症・寄生虫症一般  (GD01010H) ,  分子構造  (EB03020Y) ,  ウイルス感染の生理と病原性  (EG04042Y)

タイトルに関連する用語 (4件)： SARS-CoV-2 ,  中和抗体 ,  応答 ,  逃避