文献

J-GLOBAL ID：202202211791556972   整理番号：22A1030530

HFpEF患者における左室駆出率悪化の予測因子と死亡率【JST・京大機械翻訳】

Predictors and Mortality for Worsening Left Ventricular Ejection Fraction in Patients With HFpEF

著者 (32件)： Chen Liling (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Huang Zhidong (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Huang Zhidong (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Zhao Xiaoli (Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China) ,  Liang Jingjing (Department of Cardiology, Shunde Hospital, Southern Medical University, Guangzhou, China) ,  Lu Xiaozhao (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Lu Xiaozhao (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  He Yibo (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  He Yibo (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Kang Yu (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Kang Yu (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Xie Yun (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Xie Yun (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Liu Jin (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Liu Jin (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Liu Yong (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Liu Yong (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Yang Jin (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Yang Jin (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Yu Weixu (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Yu Weixu (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Deng Wanling (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Pan Yuxiong (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Lu Jin (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Yang Yanfang (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Xie Xujing (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Qian Xiaoxian (Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China) ,  Xu Qingbo (Department of Cardiology, Shunde Hospital, Southern Medical University, Guangzhou, China) ,  Xu Qingbo (Department of Cardiology, Maoming People’s Hospital, Maoming, China) ,  Chen Longtian (Department of Hematology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Chen Kaihong (Department of Cardiology, Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China) ,  Chen Shiqun (Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China)
資料名： Frontiers in Cardiovascular Medicine (Web)  (Frontiers in Cardiovascular Medicine (Web))
巻： 9  ページ： 820178  発行年： 2022年 
JST資料番号： U7061A  ISSN： 2297-055X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 背景:低下した左室駆出率(LVEF)の定義は,研究を通して変化し,低下したLVEFと死亡率の関連に関する研究結果は,矛盾しない。このため,この研究は,駆出率(HFpEF)が保存された心不全(HF)患者における死亡率に与える初期悪化LVEFの影響を評価し,初期悪化LVEFの独立した予測因子を確立することを目的にした。方法および結果:心臓腎改善登録からLVEF再測定によるHFpEFの全部で1,418人の患者を,この研究に含めた。LVEFは,退院後3~12か月以内にベースラインLVEFから≧5%の絶対低下として定義した。Coxとロジスティック回帰分析を,それぞれLVEF悪化に対する予後効果と予測因子を評価するために実施した。HFpEF患者184例のうち,457例(32.2%)がLVEF悪化を示した。3.2年の追跡期間中央値(四分位範囲:2.3~4.0歳)の間に,92例(6.5%)が死亡した。LVEF悪化を伴うHFpEF患者は,非悪化LVEFのそれらと比較して死亡率が高かった[9.2対5.2%;調整ハザード比(aHR):2.18,95%CI:1.35~3.52]。多変量バイナリロジスティック回帰分析において,ベースライン左室拡張末期径(LVEDD),LVEF,高密度リポ蛋白質コレステロール(HDL-C),心房細動(AF),および糖尿病(DM)は,LVEF悪化の予測因子として現れた。結論:この研究は,HFpEFの3人の患者の約1人が,追跡期間中にLVEF悪化を経験し,これは2.2倍増加する死亡率と関係することを示した。LVEDDとLVEFの増加,低HDL-Cレベル,AFとDMは,LVEF悪化の予測因子であった。LVEF悪化を伴うHF患者における予後に対する早期活性管理の効果を前向きに評価するためにはさらなる研究が必要である。登録:識別子NCT04407936。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 心臓 ,  *死亡率 ,  心房細動 ,  糖尿病 ,  *比率 ,  *因子 ,  心不全 ,  予後 ,  基準線 ,  指標 ,  *左室駆出率 ,  HDLコレステロール
準シソーラス用語： ロジスティック回帰分析 ,  *駆出率 ,  左室拡張末期径 ,  *予測因子 ,  *拡張期心不全 ,  ハザード比 , 【Automatic Indexing@JST】

著者キーワード (5件)： 駆出率保持心不全 ,  LVEFの悪化 ,  死亡率 ,  発生率 ,  予測因子

分類 (2件)： 循環系の疾患  (GJ03000C) ,  循環系疾患の治療一般  (GJ05010B)

引用文献 (32件)：

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タイトルに関連する用語 (6件)： HFpEF ,  患者 ,  左室駆出率 ,  悪化 ,  予測因子 ,  死亡率