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J-GLOBAL ID：202202213352306749   整理番号：22A0832209

Valeriana officinalis var.latifolia Miqからの選択的BuChE阻害活性を有する珍しいセスキテルペノイド-アルカロイドヒドライド【JST・京大機械翻訳】

A rare sesquiterpenoid-alkaloid hydrid with selective BuChE inhibitory activity from Valeriana officinalis var. latifolia Miq

著者 (27件)： Wang Miaomiao (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Wang Miaomiao (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Wang Miaomiao (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Wang Shuliang (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Wang Shuliang (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Li Yanan (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Li Yanan (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Wu Panfeng (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Wu Panfeng (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Wu Panfeng (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Yi Ping (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Yi Ping (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Yi Ping (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Huang Liejun (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Huang Liejun (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Huang Liejun (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Gu Wei (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Gu Wei (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Gu Wei (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Zhou Chengyan (College of Pharmaceutical Sciences, Hebei University, Baoding 071002, People’s Republic of China) ,  Hao Xiaojiang (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Hao Xiaojiang (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Hao Xiaojiang (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China) ,  Hao Xiaojiang (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China) ,  Yuan Chunmao (State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People’s Republic of China) ,  Yuan Chunmao (Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang 550014, People’s Republic of China) ,  Yuan Chunmao (School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People’s Republic of China)
資料名： Tetrahedron Letters  (Tetrahedron Letters)
巻： 92  ページ： Null  発行年： 2022年 
JST資料番号： E0366A  ISSN： 0040-4039  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： Valeriana officinalis var.latifolia Miqの根から,2つの生合成関連化合物(1および3)と同様に,希少セスキテルペノイド-アルカロイドヒドイドであるバレラノファールA(2),を単離した(A(2),および3)2つの生合成関連化合物(1および3)を,Valeriana officinalis var.latifolia Miqの根から分離した。化合物2は,最初のゲルマラン型セスキテルペノイドとテコシジンヒッドを示した。それらの構造と絶対配置を,分光分析,アルカリ加水分解法,およびX線回折によって解明した。ボルバレレン酸Aの構造を単結晶X線回折によって修正した。化合物2と3は選択的BuChE阻害活性を示し,IC_50値は0.4μg/ml~2.8μg/mlであった。化合物2とBuChEの間の可能な認識機構を分子ドッキング分析によって予測した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： X線回折 ,  分光分析 ,  X線回折分析 ,  *生合成 ,  絶対配置 ,  根
準シソーラス用語： 分子ドッキング ,  単結晶X線回折 ,  *阻害活性 ,  *Valeriana officinalis , 【Automatic Indexing@JST】

著者キーワード (5件)： Valeriana officinalis var.latifolia Miq. ,  希少セスキテルペノイド-アルカロイド水和物 ,  ボルバレレン酸A ,  構造修正 ,  BuChE阻害活性

分類 (2件)： 植物の生化学  (EH01050J) ,  アルカロイド  (CF10030D)

タイトルに関連する用語 (3件)： Valeriana ,  阻害活性 ,  セスキテルペノイド