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J-GLOBAL ID：202202213697078344   整理番号：22A0216806

統合失調症または双極性障害の家族性高リスクにおける知能,教育達成および脳構造【JST・京大機械翻訳】

Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

著者 (120件)： de Zwarte Sonja M. C. (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Brouwer Rachel M. (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Agartz Ingrid (Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway) ,  Agartz Ingrid (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden) ,  Agartz Ingrid (Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway) ,  Alda Martin (Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada) ,  Alda Martin (National Institute of Mental Health, Klecany, Czech Republic) ,  Alonso-Lana Silvia (FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain) ,  Alonso-Lana Silvia (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Bearden Carrie E. (Semel Institute for Neuroscience and Human Behavior, University of California, California, Los Angeles, USA) ,  Bearden Carrie E. (Department of Psychology, University of California, California, Los Angeles, USA) ,  Bertolino Alessandro (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ’Aldo Moro’, Bari, Italy) ,  Bonvino Aurora (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ’Aldo Moro’, Bari, Italy) ,  Bramon Elvira (Division of Psychiatry, Neuroscience in Mental Health Research Department, University College London, London, UK) ,  Buimer Elizabeth E. L. (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Cahn Wiepke (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Canales-Rodriguez Erick J. (FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain) ,  Canales-Rodriguez Erick J. (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Cannon Dara M. (Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland) ,  Cannon Tyrone D. (Department of Psychology, Yale University, New Haven, Connecticut, USA) ,  Cannon Tyrone D. (Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA) ,  Caseras Xavier (MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK) ,  Castro-Fornieles Josefina (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Castro-Fornieles Josefina (Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institute of Neuroscience, Hospital Clinic of Barcelona, Barcelona, Spain) ,  Castro-Fornieles Josefina (Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ,  Castro-Fornieles Josefina (University of Barcelona, Barcelona, Spain) ,  Chen Qiang (Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA) ,  Chung Yoonho (Department of Psychology, Yale University, New Haven, Connecticut, USA) ,  De la Serna Elena (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  De la Serna Elena (Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institute of Neuroscience, Hospital Clinic of Barcelona, Barcelona, Spain) ,  De la Serna Elena (Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ,  De la Serna Elena (University of Barcelona, Barcelona, Spain) ,  del Mar Bonnin Caterina (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  del Mar Bonnin Caterina (Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ,  del Mar Bonnin Caterina (Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain) ,  Demro Caroline (Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA) ,  Di Giorgio Annabella (IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy) ,  Doucet Gaelle E. (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA) ,  Doucet Gaelle E. (Boys Town National Research Hospital, Omaha, NE, USA) ,  Eker Mehmet Cagdas (SoCAT LAB, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey) ,  Erk Susanne (Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy, Charite Universitaetsmedizin Berlin, Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, and Berlin Institute of Health, Berlin, Germany) ,  Fatjo-Vilas Mar (FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain) ,  Fatjo-Vilas Mar (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Fears Scott C. (Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, California, USA) ,  Fears Scott C. (Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA) ,  Foley Sonya F. (Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK) ,  Frangou Sophia (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA) ,  Fullerton Janice M. (Neuroscience Research Australia, Sydney, Australia) ,  Fullerton Janice M. (School of Medical Sciences, University of New South Wales, Sydney, Australia) ,  Glahn David C. (Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA) ,  Glahn David C. (Tommy Fuss Center for Neuropsychiatric Disease Research, Boston Children’s Hospital, Boston, Massachusetts, USA) ,  Glahn David C. (Harvard Medical School, Boston, Massachusetts, USA) ,  Goghari Vina M. (Department of Psychology and Graduate Department of Psychological Clinical Science, University of Toronto, Toronto, Ontario, Canada) ,  Goikolea Jose M. (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Goikolea Jose M. (Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain) ,  Goikolea Jose M. (Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain) ,  Goldman Aaron L. (Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA) ,  Gonul Ali Saffet (SoCAT LAB, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey) ,  Gonul Ali Saffet (Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, Macon, Georgia, USA) ,  Gruber Oliver (Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany) ,  Hajek Tomas (Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada) ,  Hajek Tomas (National Institute of Mental Health, Klecany, Czech Republic) ,  Hawkins Emma L. (Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK) ,  Heinz Andreas (SoCAT LAB, Department of Psychiatry, School of Medicine, Ege University, Izmir, Turkey) ,  Hidiroglu Ongun Ceren (Department of Psychology, Faculty of Arts, Dokuz Eyluel University, Izmir, Turkey) ,  Hillegers Manon H. J. (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Hillegers Manon H. J. (Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands) ,  Houenou Josselin (APHP, Mondor University Hospitals, Creteil, France) ,  Houenou Josselin (INSERM U955 Team 15 ”Translational Psychiatry”, Creteil, France) ,  Houenou Josselin (NeuroSpin neuroimaging platform, Psychiatry Team, UNIACT Lab, CEA Saclay, Gif-Sur-Yvette, France) ,  Hulshoff Pol Hilleke E. (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  Hultman Christina M. (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Ingvar Martin (Section for Neuroscience, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden) ,  Ingvar Martin (Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden) ,  Johansson Viktoria (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden) ,  Johansson Viktoria (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Jonsson Erik G. (Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway) ,  Jonsson Erik G. (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden) ,  Kane Fergus (Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, UK) ,  Kempton Matthew J. (Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, UK) ,  Koenis Marinka M. G. (Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA) ,  Koenis Marinka M. G. (Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut, USA) ,  Kopecek Miloslav (National Institute of Mental Health, Klecany, Czech Republic) ,  Kopecek Miloslav (Department of Psychiatry, Third Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Kraemer Bernd (Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany) ,  Lawrie Stephen M. (Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK) ,  Lenroot Rhoshel K. (Neuroscience Research Australia, Sydney, Australia) ,  Lenroot Rhoshel K. (School of Psychiatry, University of New South Wales, Sydney, Australia) ,  Lenroot Rhoshel K. (Department of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, New Mexico, USA) ,  Marcelis Machteld (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht, Netherlands) ,  Mattay Venkata S. (Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, USA) ,  Mattay Venkata S. (Departments of Neurology and Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA) ,  McDonald Colm (Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland) ,  Meyer-Lindenberg Andreas (Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany) ,  Michielse Stijn (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht, Netherlands) ,  Mitchell Philip B. (School of Psychiatry, University of New South Wales, Sydney, Australia) ,  Moreno Dolores (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Moreno Dolores (Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Maranon (IiSGM), School of Medicine, Universidad Complutense, Madrid, Spain) ,  Murray Robin M. (Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, UK) ,  Mwangi Benson (Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA) ,  Nabulsi Leila (Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland) ,  Newport Jason (Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada) ,  Olman Cheryl A. (Department of Psychology and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA) ,  van Os Jim (Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands) ,  van Os Jim (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht, Netherlands) ,  Overs Bronwyn J. (Neuroscience Research Australia, Sydney, Australia) ,  Ozerdem Aysegul (Department of Psychiatry, Faculty of Medicine, Dokuz Eyluel University, Izmir, Turkey) ,  Ozerdem Aysegul (Department of Neurosciences, Health Sciences Institute, Dokuz Eyluel University, Izmir, Turkey) ,  Ozerdem Aysegul (Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA) ,  Pergola Giulio (Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ’Aldo Moro’, Bari, Italy) ,  Picchioni Marco M. ,  Piguet Camille (INSERM U955 Team 15 ”Translational Psychiatry”, Creteil, France) ,  Piguet Camille (NeuroSpin neuroimaging platform, Psychiatry Team, UNIACT Lab, CEA Saclay, Gif-Sur-Yvette, France) ,  Piguet Camille ,  Piguet Camille ,  Pomarol-Clotet Edith (FIDMAG Germanes Hospitalaries Research Foundation, Barcelona, Spain) ,  Pomarol-Clotet Edith (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Radua Joaquim (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden) ,  Radua Joaquim (CIBERSAM (Centro de Investigacion Biomedica en Red de Salud Mental), Madrid, Spain) ,  Radua Joaquim (Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain)
資料名： Human Brain Mapping  (Human Brain Mapping)
巻： 43  号： 1  ページ： 414-430  発行年： 2022年 
JST資料番号： W2600A  ISSN： 1065-9471  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 統合失調症(SZ-FDRs)と診断された患者の1次親族は,より小さい効果サイズにもかかわらず,脳異常の類似パターンと患者への認知変化を示す。双極性障害(BD-FDRs)と診断された患者の一次親族は,分岐パターンを示す。平均して,頭蓋内容積は対照と比較して大きく,BD-FDRsの認知変化に関する所見は矛盾する。ここでは,標準化した方法を用い,36人の統合失調症および/または双極性障害家族コホートから,795人の個人(1,103SZ-FDRs,867人のBD-FDRs,2,190人の対照,942人の統合失調症患者,693人の双極性患者)を対象に,グローバルおよび局所脳測定(皮質および皮質下),現在のIQおよび教育的達成のメタ分析を行った。対照と比べて,SZ-FDRsは広範な薄い皮質のパターンを示したが,BD-FDRsは広い皮質表面積を有した。IQはSZ-FDRs(d=-0.42,p=3×10-5)で低く,BD-FDRs(d=-0.23,p=0.045)間のIQ減少の弱い証拠があった。両相対群は,対照と比較し,同様の教育達成を示した。IQまたは教育的達成を調整すれば,脳測定に対する群効果は中程度に変化した。変化は期待方向にあり,SZ-FDRsにおける脳異常は少なく,BD-FDRsにおいてより顕著な効果であった。結論として,SZ-FDRsとBD-FDRsは,構造的脳異常の異なるパターンを示す。対照的に,対照に比べてIQスコアが低く,学校業績も同様であった。SZ-FDRsとBD-FDRsの間の脳差がIQまたは教育的達成の調整後に残るとすれば,統合失調症または双極性障害の素因の根底にある異なる脳発達過程は,一般的な認知障害とは関係しない可能性があることを示唆する。Copyright 2022 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *教育 ,  表面積 ,  標準化 ,  *統合失調症 ,  *双極性障害 ,  皮質 ,  母集団 ,  メタ分析
準シソーラス用語： 認知障害 ,  脳機能計測 ,  ニューロイメージング ,  脳発生 , 【Automatic Indexing@JST】

著者キーワード (6件)： 双極性障害 ,  教育 ,  知能 ,  神経イメージング ,  相対性 ,  統合失調症

分類 (4件)： 精神障害  (GR03000A) ,  精神障害の診断  (GR02000T) ,  精神科の基礎医学  (GR01020I) ,  遺伝的変異  (EC01030Y)

タイトルに関連する用語 (7件)： 統合失調症 ,  双極性障害 ,  家族 ,  リスク ,  知能 ,  教育 ,  脳構造