文献

J-GLOBAL ID：202202214939553665   整理番号：22A0734970

急性SARS-CoV-2またはMIS-Cで診断された入院小児における神経症状の有病率と危険因子【JST・京大機械翻訳】

Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C

著者 (55件)： Fink Ericka L. (Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, Pittsburgh, Pennsylvania; Safar Center for Resuscitation Research, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania) ,  Robertson Courtney L. (Departments of Anesthesiology and Critical Care Medicine, and Pediatrics of The Johns Hopkins University SOM, Baltimore, Maryland) ,  Wainwright Mark S. (Division of Pediatric Neurology, University of Washington, Seattle Children’s Hospital, Seattle, Washington) ,  Roa Juan D. (Department of Pediatrics, Universidad Nacional de Colombia and Fundacion Universitaria de Ciencias de la Salud, Bogota, Colombia) ,  Lovett Marlina E. (Division of Critical Care Medicine, Department of Pediatrics, Nationwide Children’s Hospital, The Ohio State University, Columbus, Ohio) ,  Stulce Casey (Department of Pediatrics, University of Chicago, Chicago, Illinois) ,  Yacoub Mais (Division of Critical Care, Department of Pediatrics, UMC Children’s Hospital, Las Vegas, Nevada) ,  Potera Renee M. (Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas) ,  Zivick Elizabeth (Division of Pediatric Critical Care Medicine, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina) ,  Holloway Adrian (Division of Critical Care, Department of Pediatrics, University of Maryland Medical Center, Baltimore, Maryland) ,  Nagpal Ashish (Department of Pediatrics, Section of Critical Care Medicine, Oklahoma Children’s Hospital at OU health, Oklahoma University College of Medicine, Oklahoma City, Oklahoma) ,  Wellnitz Kari (Division of Pediatric Critical Care, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa) ,  Czech Theresa (Division of Pediatric Neurology, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa) ,  Even Katelyn M. (Division of Pediatric Critical Care Medicine, Penn State College of Medicine, Hershey, Pennsylvania) ,  Brunow de Carvalho Werther (Department of Pediatrics, University of Sao Paulo, Sao Paulo, Brazil) ,  Rodriguez Isadora Souza (Department of Pediatrics, University of Sao Paulo, Sao Paulo, Brazil) ,  Schwartz Stephanie P. (Department of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina) ,  Walker Tracie C. (Department of Pediatrics, University of North Carolina at Chapel Hill Hospitals, Chapel Hill, North Carolina) ,  Campos-Mino Santiago (Pediatric Intensive Care Unit, Hospital Metropolitano, Quito, Ecuador) ,  Dervan Leslie A. (Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington) ,  Geneslaw Andrew S. (Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York) ,  Sewell Taylor B. (Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York) ,  Pryce Patrice (Division of Pediatric Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, Morgan Stanley Children’s Hospital New York-Presbyterian Hospital, New York, New York) ,  Silver Wendy G. (Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York) ,  Lin Jieru Egeria (Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York) ,  Vargas Wendy S. (Division of Child Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, New York) ,  Topjian Alexis (Division of Critical Care Medicine at The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania) ,  Alcamo Alicia M. (Division of Critical Care Medicine at The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania) ,  McGuire Jennifer L. (Division of Neurology at The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania) ,  Dominguez Rojas Jesus Angel (Division of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru) ,  Munoz Jaime Tasayco (Division of Pediatric Critical Care, Department of Pediatrics, Hospital de Emergencia Villa El Salvador, Lima, Peru) ,  Hong Sue J. (Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois) ,  Muller William J. (Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois) ,  Doerfler Matthew (Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois) ,  Williams Cydni N. (Division of Pediatric Critical Care, Department of Pediatrics Pediatric Critical Care and Neurotrauma Recovery Program Portland, Oregon Health & Science University, Oregon) ,  Drury Kurt (Division of Pediatric Critical Care, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon) ,  Bhagat Dhristie (Department of Neurology, NYU Langone Health, New York, New York) ,  Nelson Aaron (Department of Neurology, NYU Langone Health, New York, New York) ,  Price Dana (Department of Neurology, NYU Langone Health, New York, New York) ,  Dapul Heda (Division of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children’s Hospital at NYU Langone Health, New York, New York) ,  Santos Laura (Division of Pediatric Critical Care, Department of Pediatrics, Hassenfeld Children’s Hospital at NYU Langone Health, New York, New York) ,  Kahoud Robert (Division of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota) ,  Francoeur Conall (Department of Pediatrics, CHU de Quebec - Universite Laval Research Center, Quebec City, Quebec, Canada) ,  Appavu Brian (Division of Neurology, Barrow Neurological Institute at Phoenix Children’s Hospital, University of Arizona, College of Medicine, Phoenix, Arizona) ,  Guilliams Kristin P. (Departments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri) ,  Agner Shannon C. (Departments of Neurology, Pediatrics, and Radiology, Washington University in St. Louis, St. Louis, Missouri) ,  Walson Karen H. (Department of Pediatric Critical Care Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia) ,  Rasmussen Lindsey (Pediatric Critical Care Medicine, Lucile Packard Children’s Hospital, Stanford University, Stanford, California) ,  Janas Anna (Pediatric Critical Care Medicine, Lucile Packard Children’s Hospital, Stanford University, Stanford, California) ,  Ferrazzano Peter (Department of Pediatrics, University of Wisconsin, Madison, Wisconsin) ,  Farias-Moeller Raquel (Division Child Neurology, Department of Neurology, Medical College of Wisconsin, Children’s Wisconsin, Milwaukee, Wisconsin) ,  Snooks Kellie C. (Department of Pediatrics, Medical College of Wisconsin, Children’s Wisconsin, Milwaukee, Wisconsin) ,  Chang Chung-Chou H. (Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania) ,  Yun James (Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania) ,  Schober Michelle E. (Division of Critical Care of the University of Utah, Department of Pediatrics, Salt Lake City, Utah)
資料名： Pediatric Neurology  (Pediatric Neurology)
巻： 128  ページ： 33-44  発行年： 2022年 
JST資料番号： W3302A  ISSN： 0887-8994  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 著者らの目的は,急性重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)感染または小児(MIS-C)の多系炎症症候群の入院患者における神経症状の頻度,早期影響,および危険因子を特徴づけることであった。方法:2020年1月~2021年4月にSARS-CoV-2関連状態の陽性SARS-CoV-2試験または臨床診断で入院した18歳未満の小児における神経症状の多施設,横断的研究。神経学的症状の危険因子を同定するための多変量ロジスティック回帰を実施した。1493人の子供のうち,1278人(86%)は,MIS-Cで急性SARS-CoV-2と215人(14%)と診断された。全体として,コホートの44%(40%急性SARS-CoV-2と66%MIS-C)は,少なくとも1つの神経症状を示した。急性SARS-CoV-2およびMIS-C診断の小児における最も一般的な神経学的所見は,頭痛(16%および47%)および急性脳症(15%および22%)であり,いずれもP<0.05であった。神経学的症状の子供は集中治療室(ICU)治療(51%対22%),P<0.001を必要とした。多変量ロジスティック回帰において,神経学的症状を有する子供は高齢(オッズ比[OR]1.1および95%信頼区間[CI]1.07から1.13)であり,MIS-C対急性SARS-CoV-2(OR2.16,95%CI 1.45から3.24),既存の神経学的および代謝的条件(OR 3.48,95%CI 1.04から5.15,およびOR 1.65,95%CI 1.04から2.64),および咽頭(OR 1.43,95%CI 1.03から2.64)または腹痛(OR 1.43,95%CI 1.03から2.00),および腹痛(OR 1.43,95%CI 1.03から2.00),すべてのP<0.05であった。この多施設研究では,SARS-CoV-2関連状態により入院した子供の44%は,ICU入院および既存の神経学的状態と関係した神経学的症状を経験した。機能的障害と神経保護戦略の入院後評価と支援は,極めて重要である。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 咽頭 ,  炎症 ,  頭痛 ,  感染 ,  子供 ,  *症状 ,  *入院 ,  母集団 ,  ICU【医療】 ,  腹痛 ,  *神経症状 ,  *危険因子
準シソーラス用語： *SARSウイルス ,  *重症急性呼吸器症候群 ,  ロジスティック回帰分析 , 【Automatic Indexing@JST】

著者キーワード (4件)： 神経症状 ,  小児 ,  SARS-CoV-2 ,  小児の発達

分類 (1件)： 感染症・寄生虫症一般  (GD01010H)

タイトルに関連する用語 (8件)： SARS-CoV-2 ,  MIS-C ,  診断 ,  入院 ,  小児 ,  神経症状 ,  有病率 ,  危険因子