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J-GLOBAL ID：202202215485219386   整理番号：22A0431939

マウスに対するデキストラン硫酸ナトリウム誘発腸粘膜損傷に対するAtractylodes macrocephalae Koidzからの多糖類の保護効果【JST・京大機械翻訳】

Protective effects of polysaccharides from Atractylodes macrocephalae Koidz. against dextran sulfate sodium induced intestinal mucosal injury on mice

著者 (33件)： Kai Lixia (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Kai Lixia (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Kai Lixia (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Kai Lixia (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Kai Lixia (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Zong Xin (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Zong Xin (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Zong Xin (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Zong Xin (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Zong Xin (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Jiang Qin (College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, PR China) ,  Lu Zeqing (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Lu Zeqing (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Lu Zeqing (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Lu Zeqing (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Lu Zeqing (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Fengqin (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Fengqin (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Fengqin (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Fengqin (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Fengqin (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Yizhen (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Yizhen (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Yizhen (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Yizhen (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Yizhen (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Tenghao (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China) ,  Wang Tenghao (Zhejiang Qinglian Food Co., Ltd., Jiaxing 314399, PR China) ,  Jin Mingliang (Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Zhejiang University, Hangzhou 310058, PR China) ,  Jin Mingliang (Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou 310058, PR China) ,  Jin Mingliang (Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, PR China) ,  Jin Mingliang (National Engineering Laboratory for Feed Safety and Pollution Prevention and Controlling, Zhejiang University, Hangzhou 310058, PR China) ,  Jin Mingliang (Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China)
資料名： International Journal of Biological Macromolecules  (International Journal of Biological Macromolecules)
巻： 195  ページ： 142-151  発行年： 2022年 
JST資料番号： T0898A  ISSN： 0141-8130  CODEN： IJBMDR  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 本研究では,Atractylodes macrocephalae Koidz.由来の水溶性多糖類(AMP)を分離し,調製した。マウスにおけるデキストラン硫酸ナトリウム(DSS)により誘導された腸管粘膜バリア損傷に対するAMPの保護作用を調べた。AMP処理は体重を有意に軽減し,結腸長を短縮し,DSSにより誘導される結腸損傷を改善することを見出した。重要なことに,AMPは炎症誘発性サイトカインTNF-α,IL-1βおよびIL-6の過剰発現を防ぎ,結腸における好中球の浸潤を減少させた。さらに,AMPはムチン2とタイトジャンクション蛋白質クラウジン-1の発現を増加させることができた。AMPはまた,全体的な豊かさと多様性を強化することにより腸微生物叢を調節し,例えばClostridium sensu stricto 1とEscherichia Shigellaに対する有害な細菌の割合を大きく減少させ,しかしながら,FaecalibaculumとBifidobacteriumのような潜在的有益な細菌の比率を増加させた。本研究は,腸バリア機能障害に対する多糖類AMPの保護作用に関する重要な洞察を提供し,これらの生物学的巨大分子の健康-有益な性質の根底にある機構を提供する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 細菌 ,  *多糖類 ,  結腸 ,  *腸粘膜 ,  赤痢菌属 ,  Clostridium ,  Escherichia ,  ミクロフローラ ,  ビフィズス菌 ,  好中球 ,  TNFα ,  インターロイキン6 ,  炎症性サイトカイン
準シソーラス用語： *デキストラン硫酸ナトリウム ,  過剰発現 , 【Automatic Indexing@JST】

著者キーワード (4件)： Atracylodes macrocephalae ,  多糖類 ,  腸管バリア機能 ,  腸内微生物相

分類 (1件)： 消化器の基礎医学  (GH01020E)

タイトルに関連する用語 (8件)： マウス ,  デキストラン硫酸ナトリウム ,  誘発 ,  腸粘膜 ,  損傷 ,  Atractylodes ,  多糖類 ,  保護効果