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J-GLOBAL ID：202202216954643402   整理番号：22A0150128

ヒト腸内真菌Penicillium oxalicum SL2から単離した代謝産物とPXRおよびFXRに対するそれらのアゴニスト効果【JST・京大機械翻訳】

Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR

著者 (11件)： Zhao Wen-Yu (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Luan Zhi-Lin (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Sun Cheng-Peng (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Zhang Bao-Jing (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Jin Ling-Ling (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Deng Sa (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Zhang Hou-Li (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Yu Zhen-Long (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Wang Chao (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Ma Xiao-Chi (Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Pharmacy, College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical Universi...) ,  Ma Xiao-Chi (Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People’s Republic of China)
資料名： Phytochemistry  (Phytochemistry)
巻： 193  ページ： Null  発行年： 2022年 
JST資料番号： D0116B  ISSN： 0031-9422  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 腸共生真菌はヒトの健康に不可欠であり,それらの代謝産物は相互関係において鍵となる役割を果たす。本研究では,18のアルカロイドと7つのモノテルペノイドを,7つの未記載アルカロイド(ペニシロキサリンA-G),3つの未記載モノテルペノイド(ペニシロキサリンH-J),および15の報告された化合物を含む,ヒト腸真菌Penicillium oxalicum SL2の発酵から単離した。単離化合物の構造を,HRESIMS,1Dおよび2D NMR,電子円偏光二色性スペクトルおよび量子化学計算により同定した。一部の代謝産物はプレグナンX受容体(PXR)に対して中程度のアゴニスト作用を示したが,(6R)3,7-ジメチル-6,7-ジヒドロキシ-2(Z)-オクテン酸は0.43μMのEC_50値でファルネソイドX受容体(FXR)に対して有意なアゴニスト作用を示し,それは小ヘテロ二量体パートナー1(SHP1),線維芽細胞成長因子(FGF)および胆汁酸塩輸出ポンプ(BSEP)のようなFXR下流標的遺伝子および蛋白質を調査することにより検証された。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： NMR【磁気共鳴】 ,  アルカロイド ,  *代謝産物 ,  タンパク質 ,  ヒト ,  モノテルペン ,  *真菌類 ,  *Penicillium ,  二次元 ,  一次元 ,  円偏光二色スペクトル
準シソーラス用語： ヘテロ二量体 ,  *アゴニスト ,  量子化学計算 ,  *Penicillium oxalicum , 【Automatic Indexing@JST】

著者キーワード (5件)： Penicillium oxalicum SL2 ,  Trichocomaceae ,  代謝産物 ,  FXR ,  PXR

分類 (3件)： 物質の代謝  (EH02050Q) ,  アルカロイド  (CF10030D) ,  植物の生化学  (EH01050J)

タイトルに関連する用語 (9件)： ヒト ,  腸 ,  真菌 ,  Penicillium ,  単離 ,  代謝産物 ,  PXR ,  FXR ,  アゴニスト