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J-GLOBAL ID：202202217780250209   整理番号：22A0889756

早期発症,中間発症および後期発症結腸直腸癌の腫瘍微小環境における免疫細胞プロファイル【JST・京大機械翻訳】

Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer

著者 (45件)： Ugai Tomotaka (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Ugai Tomotaka (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Vaeyrynen Juha P. (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Juha P. (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Juha P. (Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland) ,  Lau Mai Chan (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Borowsky Jennifer (Conjoint Gastroenterology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia) ,  Akimoto Naohiko (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Vaeyrynen Sara A. (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Zhao Melissa (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Zhong Rong (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Zhong Rong (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Haruki Koichiro (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Dias Costa Andressa (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Fujiyoshi Kenji (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Arima Kota (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Wu Kana (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Chan Andrew T. (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Chan Andrew T. (Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Chan Andrew T. (Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA) ,  Chan Andrew T. (Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Cao Yin (Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA) ,  Cao Yin (Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA) ,  Cao Yin (Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA) ,  Song Mingyang (Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Song Mingyang (Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Song Mingyang (Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA) ,  Fuchs Charles S. (Yale Cancer Center, New Haven, CT, USA) ,  Fuchs Charles S. (Department of Medicine, Yale School of Medicine, New Haven, CT, USA) ,  Fuchs Charles S. (Smilow Cancer Hospital, New Haven, CT, USA) ,  Fuchs Charles S. (Genentech, South San Francisco, CA, USA) ,  Wang Molin (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Wang Molin (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  Wang Molin (Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Lennerz Jochen K. (Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA) ,  Ng Kimmie (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Meyerhardt Jeffrey A. (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Giannakis Marios (Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA) ,  Giannakis Marios (Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Giannakis Marios (Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Nowak Jonathan A. (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Ogino Shuji (Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA) ,  Ogino Shuji (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA) ,  Ogino Shuji (Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Ogino Shuji (Cancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, MA, USA)
資料名： Cancer Immunology, Immunotherapy  (Cancer Immunology, Immunotherapy)
巻： 71  号： 4  ページ： 933-942  発行年： 2022年 
JST資料番号： W4135A  ISSN： 1432-0851  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 背景:50歳前に診断された早期発症結腸直腸癌(CRC)への関心の高さにもかかわらず,早期発症CRCの免疫細胞プロファイルについてはほとんど知られていない。また,年齢50の直後に診断したCRCsが早期発症CRCと類似しているかどうかは研究されていない。したがって,CRC組織での免疫細胞浸潤は,3つの年齢群(初期発症<50-54′′中間発症,′′≧55′′後期発症)の間で,異なる異質性パターンを示す可能性があると仮定した。方法:35人の早期発症および73人の中間発症症例を含む,利用可能な組織データを有する1,518件の事故CRC症例を検討した。腫瘍上皮内および間質領域における免疫細胞を同定するために,著者らは,以下のマーカーを用いて,ディジタル画像分析と機械学習アルゴリズムを組み合わせた3つの多重免疫蛍光アッセイを開発した。(1)CD3,CD4,CD8,CD45RO(PTPRC),およびT細胞のFOXP3;(2)マクロファージに対するCD68,CD86,IRF5,MAFおよびMRC1(CD206);(3)骨髄細胞に対するARG1,CD14,CD15,CD33およびHLA-DR。結果:年齢群間の比較は,後期発症CRCと比較して,0.005の厳密な両側αレベルで統計的に有意な差を示したが,早期発症CRCは,腫瘍浸潤リンパ球(P=0.013),腫瘍周囲反応(P=0.025)および腫瘍周囲リンパ球反応(P=0.044)のより低いレベルを示す傾向があった。後期発症CRCと比較して,中間発症CRCは,全体のマクロファージ(P=0.050),M1様マクロファージ(P=0.062),CD14+HLA-DR+細胞(P=0.015)およびCD3+CD4+FOXP3+細胞(P=0.039)のより低い密度を示す傾向があった。結論:この仮説生成研究は,診断時の年齢による腫瘍微小環境における病理組織学的リンパ球反応パターン,マクロファージおよび調節性T細胞の可能な違いを示唆する。Copyright The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 間質組織 ,  蛍光抗体法 ,  *腫瘍 ,  上皮 ,  リンパ球 ,  T細胞 ,  マクロファージ ,  疫学 ,  骨髄細胞 ,  *結腸腫瘍 ,  *直腸腫瘍 ,  HLA-DR ,  制御性T細胞 ,  細胞浸潤
準シソーラス用語： *免疫細胞 ,  CD68抗原 ,  *結腸直腸癌 , 【Automatic Indexing@JST】

著者キーワード (4件)： 免疫学 ,  若年発症 ,  大腸腫瘍 ,  分子病理学的疫学

分類 (1件)： 消化器の腫よう  (GH04000D)

タイトルに関連する用語 (7件)： 早期 ,  発症 ,  後期発症 ,  結腸直腸癌 ,  腫瘍微小環境 ,  免疫細胞 ,  プロファイル