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J-GLOBAL ID：202202218975521154   整理番号：22A0705655

Chagas病治療の可能性を有するプロテアソーム標的化アリールスルホンアミドの同定【JST・京大機械翻訳】

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease

著者 (16件)： Lima Marta L. (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Tulloch Lindsay B. (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Corpas-Lopez Victoriano (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Carvalho Sandra (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Wall Richard J. (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Milne Rachel (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Rico Eva (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Patterson Stephen (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Gilbert Ian H. ,  Moniz Sonia (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  MacLean Lorna (Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Torrie Leah S. (Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Morgillo Carmine (Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Horn David (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Zuccotto Fabio (Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom) ,  Wyllie Susan (Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom)
資料名： Antimicrobial Agents and Chemotherapy  (Antimicrobial Agents and Chemotherapy)
巻： 66  号： 1  ページ： Null  発行年： 2022年 
JST資料番号： E0802A  ISSN： 0066-4804  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 表現型スクリーニングにより,Chagas病の原因菌であるクルーズトリパノソーマに対して活性を有するアリールスルホンアミド化合物を同定した。作用研究の包括的様式は,この化合物が主にT.cruziプロテアソームを標的とし,キモトリプシン様活性を触媒するβ4とβ5サブユニットとの界面で結合することを明らかにした。Please refer to the publisher for the copyright holders. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 界面 ,  キモトリプシン ,  表現型 ,  サブユニット ,  化合物 ,  スクリーニング ,  Trypanosoma cruzi ,  *ターゲティング ,  *トリパノソーマ症 ,  *プロテアソーム
準シソーラス用語： *Chagas病 , 【Automatic Indexing@JST】

分類 (1件)： 抗原虫薬・駆虫薬の基礎研究  (GW17080G)

タイトルに関連する用語 (6件)： Chagas病 ,  治療 ,  可能性 ,  プロテアソーム ,  標的化 ,  同定