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J-GLOBAL ID：202202219267931943   整理番号：22A0983647

交感神経性神経ストレスは骨芽細胞エキソソームMiR-21の骨恒常性を破壊し骨減少症を促進する【JST・京大機械翻訳】

Sympathetic Neurostress Drives Osteoblastic Exosomal MiR-21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia

著者 (26件)： Hu Cheng-Hu (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Hu Cheng-Hu (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, 710032, China) ,  Sui Bing-Dong (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Liu Jin (Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China) ,  Dang Lei (Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China) ,  Chen Ji (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Zheng Chen-Xi (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Shi Songtao (South China Center of Craniofacial Stem Cell Research, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China) ,  Zhao Na (Institute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710032, China) ,  Dang Min-Yan (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Dang Min-Yan (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  He Xiao-Ning (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  He Xiao-Ning (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  Zhang Li-Qiang (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Zhang Li-Qiang (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  Gao Ping-Ping (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Gao Ping-Ping (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  Chen Nan (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Kuang Hui-Juan (Institute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710032, China) ,  Kuang Hui-Juan (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  Chen Kai (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Xu Xiao-Lin (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China) ,  Yu Xiao-Rui (Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, 710032, China) ,  Zhang Ge (Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China) ,  Jin Yan (State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, 710032, Chi...) ,  Jin Yan (Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, Shaanxi, 710032, China)
資料名： Small Methods  (Small Methods)
巻： 6  号： 3  ページ： e2100763  発行年： 2022年 
JST資料番号： W3681A  ISSN： 2366-9608  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 神経支配と細胞外小胞分泌は,メッセージ伝達のための局所組織微小環境において共存するが,それらが器官ホメオスタシスを調節するために相互接続されるかどうかは,未知のままである。交感神経-アドレナリン作動性活性化はストレス誘発性鬱病に関与し,骨損失をもたらすが,機構および治療法は不完全に解明される。本研究では,β_1/2アドレナリン受容体(β1/2-AR)シグナル伝達を介した交感神経ストレスが骨芽細胞におけるマイクロRNA,miR-21の転写応答を誘発し,破骨細胞形成を指示するためにエキソソームを介して破骨細胞前駆細胞に伝達されることを明らかにした。miR-21欠損がβ1/2-ARアゴニストイソプロテレノール(ISO)誘導骨減少を遅らせたことを確認した後,2つの臨床関連薬物,ジメチルアミロリドとオメプラゾールによるエキソソーム放出の薬理学的阻害は,骨芽細胞miR-21移動を抑制し,ISOと慢性可変ストレス(CVS)誘導鬱病条件の両方で骨損失を改善することを示した。骨芽細胞miR-21を特異的にサイレンシングする標的化デリバリーアプローチをさらに適用し,これは骨リモデリングバランスを救済し,ISOおよびCVS誘導骨減少症を改善するのに有効である。これらの結果は,神経キューが器官ホメオスタシスを調節するためにエキソソームマイクロRNAコミュニケーションを駆動し,心理的ストレス下の骨損失を打ち消すための実行可能な戦略の確立を助けるという以前に認識されていないパラダイムを解読する。Copyright 2022 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *骨 ,  *交感神経系 ,  *ストレス ,  環境 ,  ホメオスタシス ,  うつ病 ,  薬理学 ,  ターゲティング ,  骨粗鬆症 ,  細胞情報伝達 ,  *骨芽細胞 ,  神経支配 ,  遺伝子サイレンシング
準シソーラス用語： マイクロRNA ,  微小環境 ,  *エキソソーム ,  骨損失 , 【Automatic Indexing@JST】

著者キーワード (5件)： 骨 ,  うつ病 ,  エキソソーム ,  マイクロRNA ,  交感神経系

分類 (1件)： 運動器系の基礎医学  (GG01020B)

タイトルに関連する用語 (11件)： 交感神経 ,  神経 ,  ストレス ,  骨芽細胞 ,  エキソソーム ,  miR-21 ,  骨 ,  恒常性 ,  破壊 ,  骨減少症 ,  促進