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J-GLOBAL ID：202202221724147403   整理番号：22A1016637

ヒトの一生にわたる脳の成長曲線

Brain charts for the human lifespan

著者 (120件)： BETHLEHEM R. A. I. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  AUYEUNG B. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  BARON-COHEN S. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  BEDFORD S. A. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  HOLT R. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  LOMBARDO M. V. (Autism Res. Centre, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  BETHLEHEM R. A. I. (Brain Mapping Unit, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  KITZBICHLER M. G. (Brain Mapping Unit, Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  SEIDLITZ J. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  VOGEL J. W. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  GUR R. E. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  GUR R. C. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  SATTERTHWAITE T. D. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  ALEXANDER-BLOCH A. F. (Dep. of Psychiatry, Univ. Pennsylvania, Philadelphia, PA, USA) ,  SEIDLITZ J. (Dep. of Child and Adolescent Psychiatry and Behavioral Sci., Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  ALEXANDER-BLOCH A. F. (Dep. of Child and Adolescent Psychiatry and Behavioral Sci., Children’s Hospital of Philadelphia, Philadelphia, PA, USA) ,  SEIDLITZ J. (Lifespan Brain Inst., Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA) ,  CHERTAVIAN C. (Lifespan Brain Inst., Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA) ,  GUR R. E. (Lifespan Brain Inst., Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA) ,  GUR R. C. (Lifespan Brain Inst., Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA) ,  ALEXANDER-BLOCH A. F. (Lifespan Brain Inst., Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA, USA) ,  WHITE S. R. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  GOODYER I. M. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  HENSON R. N. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  JONES P. B. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  KITZBICHLER M. G. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  MEDIC N. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  MORGAN S. E. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  ROMERO-GARCIA R. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  RONAN L. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  SUCKLING J. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  VERTES P. E. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  WARRIER V. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  WESTWATER M. L. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  ZIAUDDEEN H. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  BULLMORE E. T. (Dep. of Psychiatry, Univ. Cambridge, Cambridge, GBR) ,  WHITE S. R. (MRC Biostatistics Unit, Univ. Cambridge, Cambridge, GBR) ,  VOGEL J. W. (Lifespan Informatics & Neuroimaging Center, Univ. Pennsylvania, Philadelphia, PA, USA) ,  SATTERTHWAITE T. D. (Lifespan Informatics & Neuroimaging Center, Univ. Pennsylvania, Philadelphia, PA, USA) ,  ANDERSON K. M. (Dep. of Psychology, Yale Univ., New Haven, CT, USA) ,  ELLIS C. T. (Dep. of Psychology, Yale Univ., New Haven, CT, USA) ,  TURK-BROWNE N. B. (Dep. of Psychology, Yale Univ., New Haven, CT, USA) ,  ADAMSON C. (Developmental Imaging, Murdoch Children’s Res. Inst., Melbourne, Victoria, AUS) ,  BALL G. (Developmental Imaging, Murdoch Children’s Res. Inst., Melbourne, Victoria, AUS) ,  BEARE R. (Developmental Imaging, Murdoch Children’s Res. Inst., Melbourne, Victoria, AUS) ,  ADAMSON C. (Dep. of Medicine, Monash Univ., Melbourne, Victoria, AUS) ,  BEARE R. (Dep. of Medicine, Monash Univ., Melbourne, Victoria, AUS) ,  ADLER S. (UCL Great Ormond Street Inst. for Child Health, London, GBR) ,  ALEXOPOULOS G. S. (Weill Cornell Inst. of Geriatric Psychiatry, Dep. of Psychiatry, Weill Cornell Medicine, New York, USA) ,  ANAGNOSTOU E. (Dep. of Pediatrics Univ. Toronto, Toronto, CAN) ,  ANAGNOSTOU E. (Holland Bloorview Kids Rehabilitation Hospital, Toronto, CAN) ,  ARECES-GONZALEZ A. (Clinical Hospital of Chengdu Brain Sci. Inst., MOE Key Lab for NeuroInformation, Univ. Electronic Sci. and Technol. of China, Chengdu, CHN) ,  PAZ-LINARES D. (Clinical Hospital of Chengdu Brain Sci. Inst., MOE Key Lab for NeuroInformation, Univ. Electronic Sci. and Technol. of China, Chengdu, CHN) ,  ARECES-GONZALEZ A. (Univ. Pinar del Rio “Hermanos Saiz Montes de Oca”, Pinar del Rio, CUB) ,  ASTLE D. E. (MRC Cognition and Brain Sci. Unit, Univ. Cambridge, Cambridge, GBR) ,  HENSON R. N. (MRC Cognition and Brain Sci. Unit, Univ. Cambridge, Cambridge, GBR) ,  AUYEUNG B. (Dep. of Psychology, School of Philosophy, Psychology and Language Sci., Univ. Edinburgh, Edinburgh, GBR) ,  AYUB M. (Queen’s Univ., Dep. of Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, CAN) ,  AYUB M. (Univ. Coll. London, Mental Health Neuroscience Res. Dep., Div. of Psychiatry, London, GBR) ,  BAE J. (Dep. of Neuropsychiatry, Seoul National Univ. Bundang Hospital, Seongnam, KOR) ,  BALL G. (Dep. of Paediatrics, Univ. Melbourne, Melbourne, Victoria, AUS) ,  BARON-COHEN S. (Cambridge Lifetime Asperger Syndrome Serv. (CLASS), Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, GBR) ,  BENEGAL V. (Centre for Addiction Medicine, National Inst. of Mental Health and Neurosciences (NIMHANS), Bengaluru, IND) ,  BEYER F. (Dep. of Neurology, Max Planck Inst. for Human Cognitive and Brain Sci., Leipzig, DEU) ,  VILLRINGER A. (Dep. of Neurology, Max Planck Inst. for Human Cognitive and Brain Sci., Leipzig, DEU) ,  WITTE A. V. (Dep. of Neurology, Max Planck Inst. for Human Cognitive and Brain Sci., Leipzig, DEU) ,  BLANGERO J. (Dep. of Human Genetics, South Texas Diabetes and Obesity Inst., Univ. Texas Rio Grande Valley, Edinburg, TX, USA) ,  CABEZ M. Blesa (MRC Centre for Reproductive Health, Univ. Edinburgh, Edinburgh, GBR) ,  BOARDMAN J. P. (MRC Centre for Reproductive Health, Univ. Edinburgh, Edinburgh, GBR) ,  SULLIVAN G. (MRC Centre for Reproductive Health, Univ. Edinburgh, Edinburgh, GBR) ,  BORZAGE M. (Fetal and Neonatal Inst., Div. of Neonatology, Children’s Hospital Los Angeles, Dep. of Pediatrics, Keck School of Medicine, Univ. Southern California, Los Angeles, CA, USA) ,  BOSCH-BAYARD J. F. (McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological Inst., Montreal, Quebec, CAN) ,  BOSCH-BAYARD J. F. (McGill Univ., Montreal, Quebec, CAN) ,  CHAKRAVARTY M. M. (McGill Univ., Montreal, Quebec, CAN) ,  BOURKE N. (Dep. of Brain Sci., Imperial Coll. London, London, GBR) ,  SHARP D. (Dep. of Brain Sci., Imperial Coll. London, London, GBR) ,  BOURKE N. (Care Res. and Technol. Centre, Dementia Res. Inst., London, GBR) ,  CALHOUN V. D. (Tri-institutional Center for Translational Res. in Neuroimaging and Data Sci. (TReNDS), Georgia State Univ., Georgia Inst. of Technol., and Emory Univ., Atlanta, GA, USA) ,  CHAKRAVARTY M. M. (Computational Brain Anatomy (CoBrA) Lab., Cerebral Imaging Centre, Douglas Mental Health Univ. Inst., Montreal, Quebec, CAN) ,  CHEN C. (Penn Statistics in Imaging and Visualization Center, Dep. of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Univ. Pennsylvania, Philadelphia, PA, USA) ,  SHINOHARA R. T. (Penn Statistics in Imaging and Visualization Center, Dep. of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Univ. Pennsylvania, Philadelphia, PA, USA) ,  CHETELAT G. (Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Inst. Blood and Brain @ Caen-Normandie, Cyceron, Caen, FRA) ,  DELARUE M. (Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Inst. Blood and Brain @ Caen-Normandie, Cyceron, Caen, FRA) ,  LANDEAU B. (Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Inst. Blood and Brain @ Caen-Normandie, Cyceron, Caen, FRA) ,  PALY L. (Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Inst. Blood and Brain @ Caen-Normandie, Cyceron, Caen, FRA) ,  CHONG Y. S. (Singapore Inst. for Clinical Sci., Agency for Sci., Technol. and Res., Singapore, SGP) ,  CHONG Y. S. (Dep. of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National Univ. Singapore, Singapore, SGP) ,  COLE J. H. (Centre for Medical Image Computing (CMIC), Univ. Coll. London, London, GBR) ,  COLE J. H. (Dementia Res. Centre (DRC), Univ. Coll. London, London, GBR) ,  CORVIN A. (Dep. of Psychiatry, Trinity Coll., Dublin, IRL) ,  COSTANTINO M. (Cerebral Imaging Centre, Douglas Mental Health Univ. Inst., Verdun, Quebec, CAN) ,  COSTANTINO M. (Undergraduate program in Neuroscience, McGill Univ., Montreal, Quebec, CAN) ,  COURCHESNE E. (Dep. of Neuroscience, Univ. California, San Diego, San Diego, CA, USA) ,  PIERCE K. (Dep. of Neuroscience, Univ. California, San Diego, San Diego, CA, USA) ,  COURCHESNE E. (Autism Center of Excellence, Univ. California, San Diego, San Diego, CA, USA) ,  CRIVELLO F. (Inst. of Neurodegenerative Disorders, CNRS UMR5293, CEA, Univ. Bordeaux, Bordeaux, FRA) ,  MAZOYER B. (Inst. of Neurodegenerative Disorders, CNRS UMR5293, CEA, Univ. Bordeaux, Bordeaux, FRA) ,  CROPLEY V. L. (Melbourne Neuropsychiatry Centre, Univ. Melbourne, Melbourne, Victoria, AUS) ,  DI BIASE M. A. (Melbourne Neuropsychiatry Centre, Univ. Melbourne, Melbourne, Victoria, AUS) ,  LV J. (Melbourne Neuropsychiatry Centre, Univ. Melbourne, Melbourne, Victoria, AUS) ,  ZALESKY A. (Melbourne Neuropsychiatry Centre, Univ. Melbourne, Melbourne, Victoria, AUS) ,  CROSBIE J. (Hospital for Sick Children, Toronto, Ontario, CAN) ,  HAMMILL C. F. (Hospital for Sick Children, Toronto, Ontario, CAN) ,  PAUSOVA Z. (Hospital for Sick Children, Toronto, Ontario, CAN) ,  SCHACHAR R. J. (Hospital for Sick Children, Toronto, Ontario, CAN) ,  CROSSLEY N. (Dep. of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, CHL) ,  CROSSLEY N. (Dep. of Psychosis Studies, Inst. of Psychiatry, Psychology and Neuroscience, King’s Coll. London, London, GBR) ,  MCGUIRE P. (Dep. of Psychosis Studies, Inst. of Psychiatry, Psychology and Neuroscience, King’s Coll. London, London, GBR) ,  CROSSLEY N. (Instituto Milenio Intelligent Healthcare Engineering, Santiago, CHL) ,  DELORME R. (Child and Adolescent Psychiatry Dep., Robert Debre Univ. Hospital, AP-HP, Paris, FRA) ,  DELORME R. (Human Genetics and Cognitive Functions, Inst. Pasteur, Paris, FRA) ,  DESRIVIERES S. (Social, Genetic and Developmental Psychiatry Centre, Inst. of Psychiatry, Psychology and Neuroscience, King’s Coll. London, London, GBR) ,  DEVENYI G. A. (Cerebral Imaging Centre, McGill Dep. of Psychiatry, Douglas Mental Health Univ. Inst., Montreal, QC, CAN) ,  DEVENYI G. A. (Dep. of Psychiatry, McGill Univ., Montreal, QC, CAN) ,  DI BIASE M. A. (Dep. of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) ,  DOLAN R. (Max Planck UCL Centre for Computational Psychiatry and Ageing Res., Univ. Coll. London, London, GBR) ,  DOLAN R. (Wellcome Centre for Human Neuroimaging, London, GBR) ,  WAGSTYL K. (Wellcome Centre for Human Neuroimaging, London, GBR) ,  DONALD K. A. ,  DONALD K. A.
資料名： Nature (London)  (Nature (London))
巻： 604  号： 7906  ページ： 525-533  発行年： 2022年04月21日 
JST資料番号： D0193B  ISSN： 0028-0836  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： この数十年の間に,脳画像化法はヒト脳の基礎研究や臨床研究で広く利用されるツールになった。しかし,身長や体重などの人体計測学的特徴を用いる成長曲線とは異なり,脳画像計測では継続的に個人差を定量するための参照規準はこれまでなかった。今回我々は,現在あるいは将来の試料のMRIデータから得た脳形態を基準に照らして評価するためのインタラクティブなオープンリソースを構築した(http://www.brainchart.io/)。我々は,現在利用可能な最も大規模で最も包括的なデータセットに基づいてこうした参照成長曲線を作ることを目標とし,世界の人々の多様性と比較してMRI研究に既知の偏りがあることによる限界は認めた上で,100件以上の一次研究での妊娠115日齢から100歳までの10万1457人について,12万3984例のMRI走査データを集めた。MRIの計測値は,脳の構造的変化の非線形軌跡に対するパーセンタイルスコアと,生涯にわたる変化率で定量した。脳の成長曲線から,これまで報告されていなかった神経発達の重大時点が見つかり,長期的評価の期間全体で個人の値が安定していることが示され,異なる一次研究間の技術的・方法的差異に対するロバスト性が実証された。パーセンタイルスコアからは,非パーセンタイルMRI表現型と比べて遺伝性が強く示され,非典型的脳構造の標準化された計測値が得られたことで,複数の神経学的・精神医学的障害にまたがる脳解剖学的変動パターンが明らかになった。以上より,脳の成長曲線は,一般に使用されている複数の脳画像化形質について標準的な軌跡を規準とした個人差のロバストな定量に向けた重要なステップとなる。Copyright Nature Japan KK 2022

シソーラス用語： 標準化 ,  *脳 ,  遺伝 ,  個体差 ,  妊娠 ,  ヒト ,  表現型 ,  *成長曲線 ,  解剖学 ,  身体測定 ,  ロバスト性 ,  身長
準シソーラス用語： 個人差 ,  神経発生 ,  脳イメージング ,  臨床研究 , 【Automatic Indexing@JST】

分類 (2件)： 中枢神経系  (EJ12030F) ,  微生物の生態  (EG03040J)

タイトルに関連する用語 (3件)： ヒト ,  脳 ,  成長曲線