文献

J-GLOBAL ID：202202224969612453   整理番号：22A0098047

臨床環境からのプラスミド仲介tet(X4)陽性大腸菌分離株の網羅的解析は動物および環境由来株と高い相関を示す【JST・京大機械翻訳】

Comprehensive analysis of plasmid-mediated tet(X4)-positive Escherichia coli isolates from clinical settings revealed a high correlation with animals and environments-derived strains

著者 (36件)： Cui Chao-Yue (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Cui Chao-Yue (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Cui Chao-Yue (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Li Xiao-Jie (Department of Laboratory Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China) ,  Chen Chong (Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China) ,  Wu Xiao-Ting (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Wu Xiao-Ting (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Wu Xiao-Ting (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  He Qian (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  He Qian (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  He Qian (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Jia Qiu-Lin (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Jia Qiu-Lin (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Jia Qiu-Lin (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Zhang Xiao-Jing (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Zhang Xiao-Jing (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Zhang Xiao-Jing (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Lin Zhuo-Yu (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Lin Zhuo-Yu (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Lin Zhuo-Yu (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Li Cang (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Li Cang (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Li Cang (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Fang Liang-Xing (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Fang Liang-Xing (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Fang Liang-Xing (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Liao Xiao-Ping (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Liao Xiao-Ping (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Liao Xiao-Ping (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Liu Ya-Hong (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Liu Ya-Hong (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Liu Ya-Hong (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Hu Bo (Department of Laboratory Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China) ,  Sun Jian (National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) ,  Sun Jian (Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China) ,  Sun Jian (Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China)
資料名： Science of the Total Environment  (Science of the Total Environment)
巻： 806  号： P2  ページ： Null  発行年： 2022年 
JST資料番号： C0501B  ISSN： 0048-9697  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 腸内細菌科における新規プラスミド媒介高レベルチゲサイクリン耐性遺伝子tet(X)の出現は,重度の細菌感染を治療するための公衆衛生リスクを増加させた。動物源で検出されたtet(X)陽性分離株の報告にもかかわらず,ヒト由来分離株と動物および環境由来分離株との疫学的関連は不明である。ここでは,中国広東省の病院で採取したtet(X4)陽性大腸菌分離株の包括的解析を行った。1001の糞便試料から合計48のtet(X4)陽性大腸菌分離株を得た。tet(X4)陽性E.coli分離株は遺伝的に多様であったが,ST48,ST10およびST877に属するある種の株はクローン的に伝達された。これらの患者分離株からのtet(X4)遺伝子の大部分は,成功裏に転写(64.6%)された接合プラスミドに位置し,一般にadA,floR,bla_TEMおよびqnrSを含む他の抗生物質耐性遺伝子と共存していた。より重要なことに,IncX1型プラスミドがtet(X4)の共通ベクターであり,これらの患者由来株(31.3%)で優勢であった。このプラスミド型は,異なる領域における異なる種から動物由来株で検出され,その強い伝達能力と広い宿主範囲を示した。さらに,系統発生分析は,患者および動物起源のある種の株が密接に関連しており,tet(X4)陽性大腸菌分離株がヒト,動物および農場環境間の交差セクタークローン伝達を有するようであることを示した。著者らの研究は,臨床設定におけるtet(X4)陽性株の限られた疫学的知識を大いに拡大して,ヒト由来tet(X4)陽性分離株と動物由来分離株の間の疫学的関連のための決定的証拠を提供する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *大腸菌 ,  遺伝 ,  遺伝子 ,  ヒト ,  細菌感染 ,  *プラスミド ,  農場 ,  公衆衛生 ,  クローン ,  疫学 ,  ベクター ,  宿主域
準シソーラス用語： 系統解析 ,  耐性遺伝子 ,  *分離株 , 【Automatic Indexing@JST】

著者キーワード (6件)： チゲサイクリン耐性 ,  tet(X4)陽性 ,  大腸菌 ,  臨床環境 ,  IncX1プラスミド ,  農場環境

分類 (2件)： 微生物学(ウイルス以外)一般  (EG03010C) ,  抗生物質一般  (GX01000E)

タイトルに関連する用語 (11件)： 臨床 ,  環境 ,  プラスミド ,  仲介 ,  TET ,  大腸菌 ,  分離株 ,  網羅的解析 ,  動物 ,  株 ,  相関