文献

J-GLOBAL ID：202202226213855931   整理番号：22A0749928

乳癌リスクに関連するLEPおよびLEPRにおける単一ヌクレオチド多型: 中国人女性における多施設症例対照研究の結果【JST・京大機械翻訳】

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case-Control Study in Chinese Females

著者 (60件)： Li Liang (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Li Liang (2School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Li Liang (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Li Liang (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Meng Xingchen (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Meng Xingchen (2School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Liu Liyuan (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Liu Liyuan (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Liu Liyuan (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Xiang Yujuan (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Xiang Yujuan (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Xiang Yujuan (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Wang Fei (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Wang Fei (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Wang Fei (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Yu Lixiang (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Yu Lixiang (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Yu Lixiang (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Zhou Fei (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Zhou Fei (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Zhou Fei (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Zheng Chao (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Zheng Chao (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Zheng Chao (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Zhou Wenzhong (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Zhou Wenzhong (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Zhou Wenzhong (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Cui Shude (5Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China) ,  Tian Fuguo (6Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, China) ,  Fan Zhimin (7Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China) ,  Geng Cuizhi (8Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China) ,  Cao Xuchen (9Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China) ,  Yang Zhenlin (10Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Binzhou Medical University, Binzhou, China) ,  Wang Xiang (11Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China) ,  Liang Hong (12Department of General Surgery, Linyi People’s Hospital, Linyi, China) ,  Wang Shu (13Department of Breast Disease Center, Peking University People’s Hospital, Beijing, China) ,  Jiang Hongchuan (14Department of General Surgery, Beijing Chaoyang Hospital, Beijing, China) ,  Duan Xuening (15Department of Breast Disease Center, Peking University First Hospital, Beijing, China) ,  Wang Haibo (16Department of Breast Center, Qingdao University Affiliated Hospital, Qingdao, China) ,  Li Guolou (17Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, China) ,  Wang Qitang (18Department of Breast Surgery, The Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, China) ,  Zhang Jianguo (19Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China) ,  Jin Feng (20Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China) ,  Tang Jinhai (21Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China) ,  Li Liang (22Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, China) ,  Zhu Shiguang (23Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, China) ,  Zuo Wenshu (24Department of Breast Cancer Center, Shandong Cancer Hospital, Jinan, China) ,  Ye Chunmiao (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Ye Chunmiao (2School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Yin Gengshen (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Yin Gengshen (2School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Ma Zhongbing (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Ma Zhongbing (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Ma Zhongbing (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Huang Shuya (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Huang Shuya (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Huang Shuya (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China) ,  Yu Zhigang (1Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Yu Zhigang (3Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China) ,  Yu Zhigang (4Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease, Jinan, China)
資料名： Frontiers in Oncology (Web)  (Frontiers in Oncology (Web))
巻： 12  ページ： 809570  発行年： 2022年 
JST資料番号： U7089A  ISSN： 2234-943X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 背景:レプチン(LEP)はその特異的受容体(LEPR)を介して生理的役割を果たし,乳癌の発生および発生に関与する。本研究は,乳癌リスクに対するLEPとLEPRをコードする遺伝子における一塩基多型(SNP)の影響を決定することを目的とした。方法:本研究では,963の乳癌症例と953の対照を登録した。LEPの5つのSNPとLEPRの2つを選択して,中国北部と東部の女性の間で乳癌感受性と選択されたSNPの相関を評価した。分析は,ボディマスインデックス(BMI),ウエスト-ヒップ率(WHR),エストロゲン受容体およびプロゲステロン受容体状態により更に層化した。リスク変異体関連遺伝子の発現パターンを,eQTLGenと癌ゲノムAtlasデータベースによる発現量的形質遺伝子座(eQTL)分析によって検出した。【結果】乳癌症例と対照群の間には,乳癌の閉経状態と家族歴において有意差があった。LEPR遺伝子の2つのSNP(rs1137101とrs4655555)は,乳癌リスクを減少して,他の5つのSNPは,乳癌リスク,rs1137101(GA対GG;調整OR=0.719,95%CI=0.578~0.894,p=0.003)とrs4655555(TT対AA;調整OR=0.574,95%CI=0.377~0.873,p=0.009)は,多発性試験のためのBonferroni補正の後,乳癌リスクを有意に低下させた。サブグループ分析では,LEPR rs1137101のGAとGA+AA遺伝子型は,Bonferroni補正後,BMI≦24kg/m2またはWHR≧0.85のサブグループで乳癌リスクの低下と関係した。さらに,rs4655555関連遺伝子LEPRおよびレプチン受容体重複転写物(LEPROT)の発現は,隣接正常組織と比較して乳癌腫瘍組織においてアップレギュレートされ,腫瘍組織におけるLEPRのより高い発現は,癌ゲノムアトラス乳房浸潤癌(TCGA-BRCA)データを用いた乳癌患者の予後不良と相関することを見出した。結論:著者らの研究は,LEPR遺伝子に位置する多型rs1137101とrs4655555が,中国の女性における乳癌リスクを低下させ,それは,乳癌の早い予測とリスク評価のために,研究に値する生体診断マーカーであり,応用されるかもしれないことを示した。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： データベース ,  *リスク ,  遺伝子 ,  遺伝子型 ,  突然変異体 ,  乳房 ,  予後 ,  *乳房腫瘍 ,  プロゲステロン受容体 ,  エストロゲン受容体 ,  ボディマスインデックス ,  *症例対照研究 ,  リスク評価 ,  *一塩基多型 ,  レプチン
準シソーラス用語： 予後不良 , 【Automatic Indexing@JST】

著者キーワード (5件)： 乳癌リスク ,  レプチン ,  LEPR ,  単一ヌクレオチド多型 ,  症例対照研究

分類 (2件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  遺伝子の構造と化学  (EC02020U)

引用文献 (50件)：

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タイトルに関連する用語 (7件)： 乳癌リスク ,  LEP ,  単一ヌクレオチド多型 ,  中国人 ,  女性 ,  施設 ,  症例対照研究