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J-GLOBAL ID：202202229946828652   整理番号：22A0923814

COVID-19からの気管吸引におけるBromAcのex-vivo粘膜溶解および抗炎症活性【JST・京大機械翻訳】

Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19

著者 (49件)： Coelho dos Reis Jordana Grazziela A. (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Ferreira Geovane Marques (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Lourenco Alice Aparecida (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Ribeiro Agata Lopes (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  da Mata Camila Pacheco da Silveira Martins (Risoleta Tolentino Neves Hospital, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  de Melo Oliveira Patricia (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Marques Daisymara Priscila de Almeida (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Ferreira Linziane Lopes (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  Clarindo Felipe Alves (Basic and Applied Virology Laboratory, Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil) ,  da Silva Murillo Ferreira (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  da Silva Murillo Ferreira (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Filho Heitor Portella Povoas (Hospital de Ilheus, Ilheus, BA, Brazil) ,  Oliveira Nilson Roberto Ribeiro (Hospital de Ilheus, Ilheus, BA, Brazil) ,  Sodre Maisah Meyhr D’Carmo (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Gadelha Sandra Rocha (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Gadelha Sandra Rocha (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Albuquerque George Rego (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Albuquerque George Rego (Department of Agricultural and Environmental Sciences (DCAA), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Maciel Bianca Mendes (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Maciel Bianca Mendes (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Mariano Ana Paula Melo (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Mariano Ana Paula Melo (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Silva Mylene de Melo (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Fontana Renato (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Fontana Renato (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Marin Lauro Juliano (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Marin Lauro Juliano (Department of Health Sciences (DCS), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Carlos Renata Santiago Alberto (Department of Agricultural and Environmental Sciences (DCAA), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Lopes Amanda Teixeira Sampaio (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Ferreira Fabricio Barbosa (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  dos Santos Uener Ribeiro (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Santana Iris Terezinha Santos de (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Fehlberg Hllytchaikra Ferraz (Laboratory of Pharmacogenomics and Molecular Epidemiology (LAFEM), Santa Cruz State University (UESC), Ilheus, BA, Brazil) ,  Rezende Rachel Passos (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Dias Joao Carlos T. (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Gross Eduardo (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Goulart Gisele Assis Castro (Department of Pharmaceuticals, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil) ,  Santiago Marie Gabriele (Department of Pharmaceuticals, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil) ,  de Lemos Ana Paula Motta Lavigne (Hospital de Ilheus, Ilheus, BA, Brazil) ,  da Conceicao Aline O. (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Romano Carla Cristina (Hospital de Ilheus, Ilheus, BA, Brazil) ,  de Carvalho Luciana Debortoli (Department of Biological Sciences, Santa Cruz State University, Ilheus, BA, Brazil) ,  Filho Olindo Assis Martins (Grupo Integrado de Pesquisas em Biomarcadores, Instituto Rene Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil) ,  Quadros Claudio Almeida (Sao Rafael Hospital and Bahia State University, Salvador, Bahia, Brazil) ,  Morris David L. (Mucpharm Pty Ltd, Sydney, NSW, Australia) ,  Morris David L. (University of New South Wales, St George & Sutherland Hospital Clinical School, Sydney, NSW, Australia) ,  Morris David L. (Department of Surgery, St George Hospital, Sydney, NSW, Australia) ,  Valle Sarah J. (Mucpharm Pty Ltd, Sydney, NSW, Australia) ,  Valle Sarah J. (University of New South Wales, St George & Sutherland Hospital Clinical School, Sydney, NSW, Australia)
資料名： Biomedicine & Pharmacotherapy  (Biomedicine & Pharmacotherapy)
巻： 148  ページ： Null  発行年： 2022年 
JST資料番号： A0845C  ISSN： 0753-3322  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： COVID-19は汎発性SARS-CoV-2に起因する致死疾患であり,公衆衛生上の脅威である。COVID-19は主に呼吸器疾患であり,しばしば喀痰保持とサイトカイン嵐と関連し,そのために治療選択肢が限られている。この点に関して,Bromelainとアセチルシステイン(NAC)の組み合わせであるBromAcの使用を評価した。両薬剤は粘膜溶解効果を示し,COVID-19を治療するために研究されている。したがって,機械的換気を必要とする重症のCOVID-19患者からの気管吸引検体におけるBromAcの粘膜溶解および抗炎症効果を調べることを試みた。COVID-19患者からの気管吸引検体を,キンコンセントの次の後に収集し,Luminexキットを用いた粘液溶解,レオメトリーおよびサイトカイン分析を行った。BromAcはex vivoでCOVID-19喀痰に用量依存性に頑健な粘膜溶解効果を示した。BromAcは抗炎症活性を示し,NAC単独および対照と比較し,サイトカインストームの作用,MIP-1α,CXCL8,MIP-1b,MCP-1およびIP-10を含むケモカイン,およびIL-9に対する調節サイトカインIL-5,IL-10,IL-13IL-1Raおよび総還元を示した。BromAcはIL-6に作用し,125及び250μgの濃度でG-CSF及びVEGF-Dの減少を示した。これらの結果は,重症のCOVID-19患者からの気管吸引物におけるBromAcex vivoの強固な粘膜溶解および抗炎症効果を示し,COVID-19の薬理学的治療としてさらに評価できる可能性を示した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *溶解 ,  換気 ,  ソケット ,  *消炎作用 ,  呼吸器疾患 ,  *粘膜 ,  薬物療法 ,  公衆衛生 ,  患者 ,  粘液 ,  喀痰 ,  ロバスト性 ,  サイトカイン ,  インターロイキン6 ,  ケモカイン

著者キーワード (5件)： BromAc ,  COVID-19 ,  気管吸引液 ,  SARS-CoV-2 ,  粘液溶解療法

分類 (3件)： 呼吸器の基礎医学  (GI01020H) ,  呼吸器疾患の治療一般  (GI05010Y) ,  医療用機器装置  (GA05020L)

タイトルに関連する用語 (4件)： 気管吸引 ,  粘膜 ,  溶解 ,  抗炎症活性