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J-GLOBAL ID：202202230448202544   整理番号：22A0920829

体外受精(IVF)を受けた女性における血清金属濃度と中間および妊娠転帰との関連【JST・京大機械翻訳】

The associations of serum metals concentrations with the intermediate and pregnancy outcomes in women undergoing in vitro fertilization (IVF)

著者 (69件)： Li Danyang (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Li Danyang (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Li Danyang (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Li Danyang (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Li Danyang (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Li Danyang (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Chunmei (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Liang Chunmei (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Chunmei (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Chunmei (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Chunmei (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Chunmei (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yu (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Cao Yu (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yu (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yu (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yu (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yu (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhu Damin (Department of Obstetrics and Gynecology, Chaohu Hospital of Anhui Medical University, Chaohu, Anhui, China) ,  Zhu Damin (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhu Damin (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhu Damin (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhu Damin (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhu Damin (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Shen Lingchao (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Shen Lingchao (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Shen Lingchao (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Shen Lingchao (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Shen Lingchao (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Shen Lingchao (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhikang (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Zhang Zhikang (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhikang (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhikang (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhikang (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhikang (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Jiang Tingting (School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang Zhou (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Zong Kai (Technical Center of Hefei Customs District, No 329 Tunxi Road, Hefei 230022, Anhui, China) ,  Liu Yajing (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Liu Yajing (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liu Yajing (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liu Yajing (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liu Yajing (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liu Yajing (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Dan (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Liang Dan (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Dan (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Dan (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Dan (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Liang Dan (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yunxia (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Cao Yunxia (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yunxia (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yunxia (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yunxia (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Yunxia (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Ji Dongmei (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Ji Dongmei (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Ji Dongmei (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Ji Dongmei (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Ji Dongmei (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Ji Dongmei (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Xu Xiaofeng (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Xu Xiaofeng (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Xu Xiaofeng (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Xu Xiaofeng (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Xu Xiaofeng (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Xu Xiaofeng (Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei 230032, Anhui, China)
資料名： Ecotoxicology and Environmental Safety  (Ecotoxicology and Environmental Safety)
巻： 233  ページ： Null  発行年： 2022年 
JST資料番号： A0825B  ISSN： 0147-6513  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 毒性および必須微量元素は,雌生殖能力に影響を及ぼすことが報告されている。しかし,IVF結果に対する金属混合物の潜在的相乗的または拮抗的効果に関する研究は限られている。金属の血清濃度が,個々に,そして,混合物として,IVFを受けている女性の妊娠結果と関係しているかどうかを評価する。安徽医科大学(n=1184)の第1付属病院からのIVFについての前向き出生コホート研究において,以前に確立された方法に従ってICP-MSによる血清金属濃度を測定した。卵母細胞/胚発達指標と追跡調査結果も収集した。金属の個体および関節効果を,ロジスティック回帰およびBayesカーネルマシン回帰(BKMR)を用いて推定した。胚期には,血清鉛(Pb)(β=-0.14,95%CI:-0.32,-0.04)とカドミウム(Cd)(β=-0.24,95%CI:-0.39,-0.09)濃度と高品質胚率の間に負の関連性を見出した;そして,血清コバルト(Co)(β=0.18,95%CI:0.05,0.31)とセレン(Se)(β=0.17,95%CI:0.06,0.41)濃度とMII率の間の正の相関を示した。妊娠転帰に関しては,血清Pbは移植成功(OR=0.85,95%CI:0.77,0.94)と臨床妊娠(OR=0.95,95%CI:0.91,0.99)と負相関した。そして,自然流産と正相関した(OR=1.39,95%CI:1.02,1.91)。BKMR分析は,金属混合物と妊娠結果の間に線形または放物線的関連を示し,Pbは最も高い後部包含確率を示した。毒性(Pb,Cd)および必須(Co,Se)金属は,Pbが主要な寄与を示す潜在的拮抗作用を含むIVF結果の同時予測因子として取り込むことができた。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *金属 ,  *濃度 ,  鉛 ,  毒性 ,  拮抗作用 ,  *血清 ,  生殖能力 ,  血清中濃度 ,  卵母細胞 ,  ICP-MS分析 ,  順相 ,  *体外受精
準シソーラス用語： ロジスティック回帰分析 ,  予測因子 ,  必須微量元素 , 【Automatic Indexing@JST】

著者キーワード (4件)： 金属 ,  毒性 ,  体外受精 ,  関節効果

分類 (2件)： 重金属とその化合物一般  (SB05021R) ,  金属及び金属化合物の毒性  (GZ02022V)

タイトルに関連する用語 (5件)： 体外受精 ,  IVF ,  女性 ,  血清 ,  妊娠転帰