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J-GLOBAL ID：202202234834492372   整理番号：22A1051929

循環SARS-CoV-2変異体の種間指向性と抗原景観【JST・京大機械翻訳】

Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants

著者 (65件)： Zhang Yali (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Zhang Yali (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wei Min (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wei Min (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wu Yangtao (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wu Yangtao (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wang Juan (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wang Juan (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Hong Yuting (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Hong Yuting (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Huang Yang (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Huang Yang (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Yuan Lunzhi (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Yuan Lunzhi (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Ma Jian (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Ma Jian (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wang Kai (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wang Kai (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wang Shaojuan (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wang Shaojuan (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Shi Yang (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Shi Yang (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Wang Zikang (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Wang Zikang (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Guo Huilin (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Guo Huilin (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Xiao Jin (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Xiao Jin (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Yang Chuanlai (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Yang Chuanlai (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Ye Jianghui (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Ye Jianghui (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Chen Jijing (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Chen Jijing (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Liu Yuxi (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Liu Yuxi (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Fu Baorong (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Fu Baorong (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Lan Miaolin (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Lan Miaolin (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Gong Peixuan (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Gong Peixuan (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Huang Zehong (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Huang Zehong (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Su Yingying (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Su Yingying (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Chen Yixin (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Chen Yixin (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Zhang Tianying (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Zhang Tianying (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Zhang Jun (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Zhang Jun (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Zhu Huachen (State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, P.R. China) ,  Zhu Huachen (Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, P.R. China) ,  Yu Hai (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Yu Hai (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Yuan Quan (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Yuan Quan (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Cheng Tong (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Cheng Tong (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Guan Yi (State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, P.R. China) ,  Guan Yi (Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, P.R. China) ,  Xia Ningshao (State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, P.R. China) ,  Xia Ningshao (National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, P.R. China) ,  Xia Ningshao (Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen University, Xiamen, P.R. China)
資料名： Cell Reports  (Cell Reports)
巻： 38  号： 12  ページ： Null  発行年： 2022年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)スパイク受容体結合ドメイン(RBD)の変異は,ウイルス宿主指向性を変化させ,中和抗体の活性に影響を及ぼす可能性がある。ここでは,18のACE2オーソログを発現する細胞における抗原変化および交差種指向性に対し,153のRBD変異体および11の世界的な循環変異体(VOC)および関心の変異体(VOI)(Omicronを含む)を検討した。いくつかのRBD変異は,非ヒト動物のACE2オーソログを発現する細胞におけるウイルス感染性を強化し,特に祖先株に対しては感受性が低い。アミノ酸(aa)439-448およびaa484の周囲の変異は,中和耐性を引き起こす可能性が高い。驚くべきことに,変異の中和-エスケープスコアの代わりに,マウスおよびフェレットにおける交差種感染の可能性の増強は,ヒトにおける突然変異の累積罹患率との正の相関を説明する。これらの知見から,循環SARS-CoV-2変異体の潜在的ドライバーに対する洞察を提示し,拡散突然変異の追跡および予測のための有益なパラメータを提供した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ウイルス ,  ウイルス感染 ,  *抗原 ,  突然変異 ,  *突然変異体 ,  ヒト ,  *変異 ,  マウス ,  感染 ,  結合部位 ,  フェレット ,  中性化 ,  中和抗体
準シソーラス用語： オルソログ ,  アンギオテンシン変換酵素2 , 【Automatic Indexing@JST】

著者キーワード (7件)： SARS-CoV-2変異体 ,  RBD変異 ,  種間屈性 ,  中性化抵抗 ,  関心の変異体 ,  関心の変異体 ,  ACE2受容体

分類 (2件)： 抗原・抗体・補体の生化学  (ED04020L) ,  分子遺伝学一般  (EC02010J)

タイトルに関連する用語 (6件)： 循環 ,  SARS-CoV-2 ,  変異体 ,  指向性 ,  抗原 ,  景観