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J-GLOBAL ID：202202236022821523   整理番号：22A0007547

化学療法後転移に取組むための蛋白質安定化高分子ナノ粒子にヒントを得たリレー薬物送達【JST・京大機械翻訳】

Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis

著者 (14件)： Cheng Hao (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Jiang Zijun (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Sun Chenkai (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Wang Zhen (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Han Guochen (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Chen Xin (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Li Tianyi (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Fan Zhechen (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Zhang Feng (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Yang Xiaoyu (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Lv Lingyu (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Zhang Huaqing (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Zhou Jianping (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...) ,  Ding Yang (Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, China Pharmaceutical University, 24 T...)
資料名： Chemical Engineering Journal  (Chemical Engineering Journal)
巻： 427  ページ： Null  発行年： 2022年 
JST資料番号： D0723A  ISSN： 1385-8947  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 化学療法のプロ-転移能力は,侵襲性癌に対する治療利点を制限する。ここでは,蛋白質安定化高分子ナノ粒子に触発されたリレー薬物送達プラットフォームを開発し,化学療法後の転移に取り組んだ。ROS応答性フェニルボロン酸(PBA)-Richカチオン高分子(RPP)架橋Doxorubicin(Dox)配位とSnail標的化siRNA(siSnail)圧縮,および天然アポリポ蛋白質A-I(apoA-I)は,ナノ粒子形成,薬物生体安定性,および腫瘍貫通のための表面電子欠損PBA部位によって誘引される。空間的に分離した構造は腫瘍細胞におけるタイミング制御リレー薬物送達を可能にし,Doxは酸性により事前放出相を与え,RPPポリマーは急速siSnail遊離のため濃縮ROSにより崩壊した。二重療法において,Dox前処理は,転移促進因子および悪化した転移をアップレギュレートしたが,siSnailによるその後の遊離は,上皮間葉転換(EMT)の中心転移レギュレーターを抑制した。末端ナノ粒子は高度な治療効果を示し,原発腫瘍収縮(腫瘍重量阻害,ΔΨ86.15%のTWI)および完全転移結節除去を達成した。この研究は,浸潤癌に対する化学療法の臨床的利点を改善する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 重合体 ,  応答特性 ,  腫瘍 ,  腫瘍細胞 ,  *高分子 ,  *薬物療法 ,  カチオン ,  プロモーター領域 ,  酸性 ,  ターゲティング ,  *ドラッグデリバリーシステム ,  *ナノ粒子 ,  siRNA
準シソーラス用語： 上皮間葉転換 ,  *高分子ナノ粒子 , 【Automatic Indexing@JST】

著者キーワード (5件)： 蛋白質安定化 ,  空間分離マルチドラッグ遮蔽 ,  リレー薬物送達 ,  バイオ応答分解 ,  化学療法後の転移抑制

分類 (2件)： 蛋白質・ペプチド一般  (EB03010N) ,  下水,廃水の化学的処理  (SC03050W)

タイトルに関連する用語 (6件)： 化学療法 ,  蛋白質安定化 ,  高分子ナノ粒子 ,  ヒント ,  リレー ,  薬物送達