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J-GLOBAL ID：202202237430452659   整理番号：22A0472811

COVID-19患者の腸内マイクロビオームにおける短鎖脂肪酸とL-イソロイシン生合成の長期障害【JST・京大機械翻訳】

Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19

著者 (56件)： Zhang Fen (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Fen (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Fen (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Fen (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Wan Yating (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Wan Yating (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Wan Yating (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Wan Yating (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zuo Tao (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zuo Tao (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zuo Tao (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zuo Tao (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Yeoh Yun Kit (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Yeoh Yun Kit (Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Liu Qin (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Liu Qin (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Liu Qin (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Liu Qin (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Lin (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Lin (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Lin (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Lin (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhang Lin (Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhan Hui (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhan Hui (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhan Hui (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Zhan Hui (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lu Wenqi (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lu Wenqi (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lu Wenqi (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lu Wenqi (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Xu Wenye (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Xu Wenye (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Xu Wenye (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Xu Wenye (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lui Grace C.Y. (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Lui Grace C.Y. (Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Li Amy Y.L. (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Cheung Chun Pan (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Cheung Chun Pan (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Cheung Chun Pan (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Cheung Chun Pan (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Wong Chun Kwok (Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Paul K.S. (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Paul K.S. (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Paul K.S. (Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Paul K.S. (Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Francis K.L. (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Francis K.L. (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Francis K.L. (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Chan Francis K.L. (Microbiota I-Center (MagIC), Shatin, Hong Kong, China) ,  Ng Siew C. (Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Ng Siew C. (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Ng Siew C. (State Key Laboratory for Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Ng Siew C. (Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China) ,  Ng Siew C. (Microbiota I-Center (MagIC), Shatin, Hong Kong, China)
資料名： Gastroenterology  (Gastroenterology)
巻： 162  号： 2  ページ： 548-561.e4  発行年： 2022年 
JST資料番号： H0767A  ISSN： 0016-5085  CODEN： GASTAB  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)感染に起因するコロナウイルス病2019(COVID-19)は,腸微生物叢組成の変化と関連する。短鎖脂肪酸(SCFAs)の代謝に関与する腸内細菌の系統発生群はSARS-CoV-2感染患者で枯渇した。疾患分解能の前後におけるCOVID-19患者における腸ミクロビオームの機能的プロファイルを特性化することを目的とした。著者らは,COVID-19と70の非COVID-19対照を有する66の抗生物質未治療患者からの糞便サンプルに関するショットガンメタゲノム配列決定を実行した。入院中および退院後1か月以上,連続糞便試料(最大6回)を採取した。疾患重症度と血液炎症マーカーとの関連で腸微生物経路を評価した。また,病気分解能の前後における糞便試料中の微生物機能の変化を測定し,糞便代謝産物の標的分析を用いてこれらの機能を検証した。非COVID-19対照と比べて,重症/臨界疾患を有するCOVID-19患者は,SCFAおよびL-イソロイシン生合成に対する腸ミクロビオームの障害能力および尿素産生に対する増強能を特徴とする,腸ミクロビオーム機能(P<0.001)において有意な変化を示した。COVID-19患者の回復後30日を超えて,腸ミクロビオームにおけるSCFAとL-イソロイシン生合成の障害は持続した。糞便代謝産物の標的分析は,疾患分解能の前後において,COVID-19患者におけるSCFAsとL-イソロイシンの糞便濃度が有意に低いことを示した。SCFAとL-イソロイシン生合成の欠如は,疾患重症度と有意に相関し,CXCL-10,NT-proB型ナトリウム利尿ペプチド,およびC反応性蛋白質(すべてのP<0.05)の血漿濃度を増加させた。COVID-19患者の腸ミクロビオームは,疾患分解能後でさえ持続するSCFAおよびL-イソロイシン生合成に対する障害能力を示した。これらの2つの微生物機能は,SARS-CoV-2感染病因および転帰における腸微生物機能の重要性を強調する宿主免疫応答と相関していた。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 微生物 ,  *生合成 ,  血漿中濃度 ,  抗生物質 ,  代謝産物 ,  系統発生 ,  臨界 ,  ミクロフローラ ,  C反応性タンパク質 ,  病因
準シソーラス用語： コロナウイルス ,  炎症マーカー ,  腸内細菌 ,  *短鎖脂肪酸 ,  重症度 , 【Automatic Indexing@JST】

著者キーワード (4件)： コロナウイルス ,  腸内マイクロバイオーム ,  微生物機能 ,  SCFAs

分類 (3件)： 消化器の疾患  (GH03000W) ,  消化器の臨床医学一般  (GH01030P) ,  消化器の診断  (GH02000P)

タイトルに関連する用語 (8件)： COVID-19 ,  患者 ,  腸 ,  短鎖脂肪酸 ,  L-イソロイシン ,  生合成 ,  長期 ,  障害