文献

J-GLOBAL ID：202202237628139525   整理番号：22A1023400

単純ヘルペスウイルス1は3インフラマソームを含むNLRファミリーピリンドメインを活性化することによりミクログリアのガスデルミンD依存性ピロトーシスを誘導する【JST・京大機械翻訳】

Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome

著者 (55件)： Hu Xiao (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Hu Xiao (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Hu Xiao (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Hu Xiao (College of Pharmacy, Jinan University, Guangzhou, China) ,  Hu Xiao (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Hu Xiao (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Zeng Qiongzhen (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Zeng Qiongzhen (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Zeng Qiongzhen (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Zeng Qiongzhen (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Zeng Qiongzhen (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Xiao Ji (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Xiao Ji (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Xiao Ji (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Xiao Ji (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Xiao Ji (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Qin Shurong (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Qin Shurong (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Qin Shurong (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Qin Shurong (College of Pharmacy, Jinan University, Guangzhou, China) ,  Qin Shurong (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Qin Shurong (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Wang Yuan (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Wang Yuan (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Wang Yuan (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Wang Yuan (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Wang Yuan (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Shan Tianhao (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Shan Tianhao (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Shan Tianhao (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Shan Tianhao (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Shan Tianhao (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Hu Di (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Hu Di (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Hu Di (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Hu Di (College of Pharmacy, Jinan University, Guangzhou, China) ,  Hu Di (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Hu Di (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Zhu Yexuan (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Zhu Yexuan (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Zhu Yexuan (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Zhu Yexuan (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Zhu Yexuan (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Liu Kaisheng (Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China) ,  Zheng Kai (School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China) ,  Wang Yifei (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Wang Yifei (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Wang Yifei (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Wang Yifei (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Wang Yifei (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China) ,  Ren Zhe (Guangzhou Jinan Biomedical Research and Development Center, College of Life Science and Technology, Institute of Biomedicine, Jinan University, Guangzhou, China) ,  Ren Zhe (The Key Laboratory of Virology of Guangdong, Jinan University, Guangzhou, China) ,  Ren Zhe (Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China) ,  Ren Zhe (Guangdong Province Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China) ,  Ren Zhe (National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, China)
資料名： Frontiers in Microbiology (Web)  (Frontiers in Microbiology (Web))
巻： 13  ページ： 838808  発行年： 2022年 
JST資料番号： U7080A  ISSN： 1664-302X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 単純ヘルペスウイルス1型(HSV-1)は,ヒトにおいて高度に流行しているウイルスであり,単純ヘルペスウイルス(HSE)のような炎症の重症型を引き起こす。ピロプトーシスは,インフラマソームおよびシステイン要求アスパラギン酸プロテアーゼ-1(カスパーゼ-1)活性化により誘導される新しい炎症性細胞死である。それにもかかわらず,HSV-1は脳炎を誘導し,細胞死機構は理解されていない。本研究では,DNAウイルスHSV-1がマウスミクログリアにおいて3(NLRP3)インフラマソームを含むNLRファミリーpyrinドメインを活性化することにより,ガスデミンD依存性ピロプトーシスを誘発し,成熟IL-1β産生および活性カスパーゼ-1(p10)放出を誘導することを初めて確認した。ミクログリアNLRP3インフラマソーム活性化の阻害はHSV-1誘導ガスデミンD依存性ピロプトーシスを抑制した。さらに,NLRP3およびIL-1β発現レベルは,ウイルス感染のない正常マウスと比較して単純ヘルペスウイルスのマウスモデルにおいて有意に増加した。まとめると,著者らのデータは,インフラマソームとGSDMD依存性ピロプトーシスの活性化が炎症を誘発するHSV-1の機序であり,ウイルス炎症のための治療ターゲットを提供することを明らかにした。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ウイルス感染 ,  炎症 ,  死 ,  ヒト ,  マウス ,  *単純ヘルペスウイルス ,  *タンパク質複合体 ,  *単純ヘルペス ,  インターロイキン1 ,  *アポトーシス ,  カスパーゼ ,  *ミクログリア
準シソーラス用語： *ドメイン構造 ,  *インフラマソーム ,  治療標的 ,  *ピロトーシス ,  マウスモデル , 【Automatic Indexing@JST】

著者キーワード (6件)： ピロトーシス ,  炎症 ,  NLRP3インフラマソーム ,  ガスデルミンD ,  単純ヘルペスウイルス1型 ,  単純ヘルペスウイルス脳炎

分類 (1件)： 免疫反応一般  (ED03010T)

引用文献 (44件)：

• Aurelian L. (2005). HSV-induced apoptosis in herpes encephalitis. Curr. Top. Microbiol. Immunol. 289 79-111. doi: 10.1007/3-540-27320-4_4
• Bergsbaken T., Fink S. L., Cookson B. T. (2009). Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7 99-109. doi: 10.1038/nrmicro2070
• Chen Z., Zhong D., Li G. (2019). The role of microglia in viral encephalitis: a review. J. Neuroinflammation 16:76. doi: 10.1186/s12974-019-1443-2
• Coll R. C., Robertson A. A., Chae J. J., Higgins S. C., Muñoz-Planillo R., Inserra M. C., et al (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat. Med. 21 248-255. doi: 10.1038/nm.3806
• Conrady C. D., Drevets D. A., Carr D. J. (2010). Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J. Neuroimmunol. 220 1-9. doi: 10.1016/j.jneuroim.2009.09.013

タイトルに関連する用語 (8件)： 単純ヘルペスウイルス1 ,  インフラマソーム ,  NLR ,  活性化 ,  ミクログリア ,  依存性 ,  ピロトーシス ,  誘導