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J-GLOBAL ID：202202238786251023   整理番号：22A0645784

迅速,定量的,高感度COVID-19血清学のための無標識プラズモンバイオセンサ: 実施と臨床的検証【JST・京大機械翻訳】

Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation

著者 (35件)： Calvo-Lozano Olalla (Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Spain) ,  Sierra Miquel (Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Spain) ,  Soler Maria (Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Spain) ,  Estevez Maria Carmen (Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Spain) ,  Chiscano-Camon Luis (Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Chiscano-Camon Luis (Shock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ruiz-Sanmartin Adolfo (Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ruiz-Sanmartin Adolfo (Shock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ruiz-Rodriguez Juan Carlos (Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ruiz-Rodriguez Juan Carlos (Shock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ferrer Ricard (Intensive Care Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Ferrer Ricard (Shock, Organ Dysfunction and Resuscitation Research Group, Vall d’Hebron Research Institute (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Gonzalez-Lopez Juan Jose (Clinical Microbiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Gonzalez-Lopez Juan Jose (Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Gonzalez-Lopez Juan Jose (Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Spain) ,  Esperalba Juliana (Clinical Microbiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Esperalba Juliana (Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Fernandez-Naval Candela (Clinical Microbiology Department, Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Fernandez-Naval Candela (Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Spain) ,  Bueno Leticia (Cellex Laboratory, CiberRes (Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, 06/06/0028), Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Spain) ,  Bueno Leticia (School of Medicine, University of Barcelona, Carrer de Casanova, 143, Spain) ,  Bueno Leticia (Department of Pneumology, Thorax Institute, Hospital Clinic of Barcelona, Spain) ,  Lopez-Aladid Ruben (Cellex Laboratory, CiberRes (Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, 06/06/0028), Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Spain) ,  Lopez-Aladid Ruben (School of Medicine, University of Barcelona, Carrer de Casanova, 143, Spain) ,  Lopez-Aladid Ruben (Department of Pneumology, Thorax Institute, Hospital Clinic of Barcelona, Spain) ,  Torres Antoni (Cellex Laboratory, CiberRes (Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, 06/06/0028), Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Spain) ,  Torres Antoni (School of Medicine, University of Barcelona, Carrer de Casanova, 143, Spain) ,  Torres Antoni (Department of Pneumology, Thorax Institute, Hospital Clinic of Barcelona, Spain) ,  Fernandez-Barat Laia (Cellex Laboratory, CiberRes (Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, 06/06/0028), Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Spain) ,  Fernandez-Barat Laia (School of Medicine, University of Barcelona, Carrer de Casanova, 143, Spain) ,  Fernandez-Barat Laia (Department of Pneumology, Thorax Institute, Hospital Clinic of Barcelona, Spain) ,  Attoumani Sarah (Unite Des Virus Emergents (UVE: Aix-Univ-IRD 190-Inserm 1207), France) ,  Charrel Remi (Unite Des Virus Emergents (UVE: Aix-Univ-IRD 190-Inserm 1207), France) ,  Coutard Bruno (Unite Des Virus Emergents (UVE: Aix-Univ-IRD 190-Inserm 1207), France) ,  Lechuga Laura M. (Nanobiosensors and Bioanalytical Applications Group (NanoB2A), Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, CIBER-BBN and BIST, Spain)
資料名： Analytical Chemistry  (Analytical Chemistry)
巻： 94  号： 2  ページ： 975-984  発行年： 2022年 
JST資料番号： A0395A  ISSN： 0003-2700  CODEN： ANCHAM  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 血清学的試験は,COVID-19パンデミック(診断および監視,および疫学的および免疫研究)の制御および管理に必須である。シグナル増幅なしに,臨床試料中の重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)抗体の迅速(<15分)同定と定量を提供するプラズモニクスに基づく専用技術を利用する直接血清学的バイオセンサアッセイを紹介した。携帯型プラズモンデバイスは,カスタム設計マルチ抗原(RBDペプチドおよびN蛋白質)センサバイオチップを用い,ポリクローナル抗体を用いた低ng mL-1範囲の検出限界に達する。また,WHO承認抗SARS-CoV-2免疫グロブリン標準を用いて実行した。COVID-19陽性と陰性試料(n=120)による臨床検証は,その優れた診断感度(99%)と特異性(100%)を示した。本バイオセンサは,疾患管理のための実験室および分散設定およびワクチン接種または治療中の免疫学的状態の評価の両者において,迅速で信頼できるCOVID-19血清学のための正確で使い易い診断ツールとして本バイオセンサを位置づけた。Copyright 2022 American Chemical Society All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ペプチド ,  免疫グロブリン ,  抗原 ,  抗体 ,  診断 ,  疫学 ,  予防接種 ,  検出限界 ,  携帯型 ,  *バイオセンサ ,  ポリクローナル抗体
準シソーラス用語： 疾病管理 ,  免疫学 ,  特異性 ,  *無標識 , 【Automatic Indexing@JST】

分類 (3件)： 蛋白質・ペプチド一般  (EB03010N) ,  分析機器  (CC02020S) ,  バイオアッセイ  (EA03060N)

タイトルに関連する用語 (7件)： 定量 ,  高感度 ,  血清学 ,  無標識 ,  実施 ,  臨床 ,  検証