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J-GLOBAL ID：202202239825793550   整理番号：22A0650558

脂質液滴特異的イメージング用のジチオフバレン縮合ベンゾチアジアゾールに基づく深赤色凝集誘起発光ルミノゲン【JST・京大機械翻訳】

Deep-Red Aggregation-Induced Emission Luminogen Based on Dithiofuvalene-Fused Benzothiadiazole for Lipid Droplet-Specific Imaging

著者 (22件)： Yu Ying (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Yu Ying (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Yu Ying (Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, China) ,  Xing Hao (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Xing Hao (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Park Hojeong (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Park Hojeong (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Zhang Ruoyao (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Zhang Ruoyao (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Peng Chen (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Peng Chen (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Sung Herman H.-Y. (Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China) ,  Williams Ian D. (Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China) ,  Ma Chao (Department of Physics, The Hong Kong University of Science and Technology, Hong Kong, China) ,  Wong Kam Sing (Department of Physics, The Hong Kong University of Science and Technology, Hong Kong, China) ,  Li Shijie (Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, China) ,  Xiong Qingping (Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, China) ,  Li Min-Hui (Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, France) ,  Zhao Zheng (Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, China) ,  Tang Ben Zhong (Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology) ,  Tang Ben Zhong (Department of Chemical and Biological Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology) ,  Tang Ben Zhong (Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, China)
資料名： ACS Materials Letters  (ACS Materials Letters)
巻： 4  号： 1  ページ： 159-164  発行年： 2022年 
JST資料番号： W6388A  ISSN： 2639-4979  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 脂質滴(LD)は,その異常が異なる疾患をもたらす多くの生物学的過程に積極的に関与する。したがって,LDの生物活性を研究することが重要である。凝集誘起発光(AIE)特性を有する赤色/近赤外(NIR)蛍光材料は,それらの非侵襲性,大きなStokesシフト,低い光損傷,および優れた光安定性のため,LDイメージングと追跡に適している。一方,二光子イメージングは,より高い分解能とより深い侵入深さの利点で現れる。本研究では,D-A構造をもつ深赤色AIE発光体(AIEgen)を構築するために,新しいアクセプタコア,ベンゾチアジアゾール-7-イリデンマロノニトリル(BSM)を提案した。AIEgenは13%の高い固体量子収率を示し,その発光スペクトルは可視およびNIR I領域をカバーする。さらに,この分子は,細胞,組織,および生きたゼブラフィッシュ胚を含むすべてのレベルの生体物質において,優れた二光子イメージング性能と脂質滴に対する高い特異性を示し,LDイメージングと生物医学研究における追跡のための高い可能性を示した。Copyright 2022 American Chemical Society All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： アクセプタ ,  安定性 ,  *液滴 ,  蛍光体 ,  発光スペクトル ,  量子収量 ,  *脂質 ,  *画像処理 ,  近赤外線 ,  生物活性 ,  侵入度 ,  Stokesシフト ,  ゼブラフィッシュ
準シソーラス用語： 光安定性 ,  脂肪滴 ,  二光子イメージング , 【Automatic Indexing@JST】

分類 (5件)： 分子化合物  (CE02000C) ,  有機化合物のルミネセンス  (BM08094A) ,  生体の顕微鏡観察法  (EA03050C) ,  診断用薬の基礎研究  (GW20010P) ,  発光素子  (NC03082G)

タイトルに関連する用語 (7件)： 脂質 ,  液滴 ,  イメージング ,  縮合 ,  赤色 ,  凝集誘起発光 ,  ルミノゲン