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J-GLOBAL ID：202202240732507970   整理番号：22A0705781

Atg2bとGskipの損失は造血幹細胞プールサイズの維持を損なう【JST・京大機械翻訳】

Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size

著者 (19件)： Sakai Shun-suke (Division of Clinical Nephrology and Rheumatology Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) ,  Hasegawa Atsushi (Department of Molecular Hematology, Tohoku University School of Medicine, Sendai, Japan) ,  Ishimura Ryosuke (Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Tamura Naoki (Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan) ,  Kageyama Shun (Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Komatsu-Hirota Satoko (Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Abe Manabu (Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan) ,  Ling Yiwei (Medical AI Center, Niigata University School of Medicine, Niigata, Japan) ,  Ling Yiwei (Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) ,  Okuda Shujiro (Medical AI Center, Niigata University School of Medicine, Niigata, Japan) ,  Okuda Shujiro (Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) ,  Funayama Manabu (Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Kikkawa Mika (Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Miura Yoshiki (Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Sakimura Kenji (Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan) ,  Narita Ichiei (Division of Clinical Nephrology and Rheumatology Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) ,  Waguri Satoshi (Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan) ,  Shimizu Ritsuko (Department of Molecular Hematology, Tohoku University School of Medicine, Sendai, Japan) ,  Komatsu Masaaki (Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo, Japan)
資料名： Molecular and Cellular Biology  (Molecular and Cellular Biology)
巻： 42  号： 1  ページ： Null  発行年： 2022年 
JST資料番号： E0266B  ISSN： 0270-7306  CODEN： MCEBD4  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： ATG2BとGSKIPを含む染色体14q32の生殖系列コピー数重複を,骨髄増殖性腫瘍(MPN)のファミリーで同定した。ここでは,Atg2bとGskipの両方を欠くマウスは,単独ではなく,造血の低下を示し,貧血を伴う子宮内の死亡を生じることを示す。ATG2BとGSKIPの重複を有するMPN患者とは対照的に,二重ノックアウト胎児肝臓における造血幹細胞(HSC)の数は,特に長期HSCで,細胞死増加により有意に減少した。Please refer to the publisher for the copyright holders. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 肝臓 ,  子宮 ,  腫瘍 ,  マウス ,  *造血 ,  *造血幹細胞 ,  コピー数 ,  骨髄増殖性疾患 ,  細胞死
準シソーラス用語： 生殖系列 ,  骨髄増殖性腫瘍 ,  胎児肝臓 , 【Automatic Indexing@JST】

分類 (2件)： 造血系  (EJ07020Y) ,  血液の基礎医学  (GK01020N)

タイトルに関連する用語 (3件)： 損失 ,  造血幹細胞 ,  サイズ