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J-GLOBAL ID：202202242127527495   整理番号：22A1024934

子宮内のジカに曝露された小児における神経発達:臨床的および分子的側面【JST・京大機械翻訳】

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

著者 (38件)： Schuler-Faccini Lavinia (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Schuler-Faccini Lavinia (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  del Campo Miguel (3Department of Pediatrics, School of Medicine, University of California San Diego, and Rady Children’s Hospital San Diego, San Diego, CA, United States) ,  Garcia-Alix Alfredo (4Neonatal Neurology, NeNe Foundation, Madrid, Spain) ,  Ventura Liana O. (5Department of Ophthalmology, Fundacao Altino Ventura, FAV, Recife, Brazil) ,  Boquett Juliano Andre (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  van der Linden Vanessa (6Hospital Barao de Lucena, Recife, Brazil) ,  Pessoa Andre (7Hospital Infantil Albert Sabin, Fortaleza, Brazil) ,  Pessoa Andre (8Universidade Estadual do Ceara, Fortaleza, Brazil) ,  van der Linden Junior Helio (9Dr. Henrique Santillo Rehabilitation and Readaptation Center, Goiania, Brazil) ,  Ventura Camila V. (5Department of Ophthalmology, Fundacao Altino Ventura, FAV, Recife, Brazil) ,  Leal Mariana Carvalho (10Universidade Federal de Pernambuco, UFPE, Recife, Brazil) ,  Kowalski Thayne Woycinck (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Kowalski Thayne Woycinck (11CESUCA-Centro Universitario, Cachoeirinha, Brazil) ,  Rodrigues Gerzson Lais (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Skilhan de Almeida Carla (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Santi Lucelia (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Santi Lucelia (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Beys-da-Silva Walter O. (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Beys-da-Silva Walter O. (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Quincozes-Santos Andre (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Guimaraes Jorge A. (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Garcez Patricia P. (12Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil) ,  Gomes Julia do Amaral (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Vianna Fernanda Sales Luiz (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Vianna Fernanda Sales Luiz (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Anjos da Silva Andre (13School of Medicine, Graduate Program in Medical Sciences-Universidade do Vale do Taquari-UNIVATES, Lajeado, Brazil) ,  Anjos da Silva Andre (14School of Medicine, Universidade do Vale do Rio dos Sinos-UNISINOS, Sao Leopoldo, Brazil) ,  Fraga Lucas Rosa (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Fraga Lucas Rosa (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Vieira Sanseverino Maria Teresa (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Vieira Sanseverino Maria Teresa (15Pontificia Universidade Catolica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil) ,  Muotri Alysson R. (3Department of Pediatrics, School of Medicine, University of California San Diego, and Rady Children’s Hospital San Diego, San Diego, CA, United States) ,  Lopes da Rosa Rafael (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Abeche Alberto Mantovani (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil) ,  Abeche Alberto Mantovani (2Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil) ,  Marcolongo-Pereira Clairton (16Centro Universitario do Estirito Santo, UNESC, Colatina, Brazil) ,  Souza Diogo O. (1Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil)
資料名： Frontiers in Genetics (Web)  (Frontiers in Genetics (Web))
巻： 13  ページ： 758715  発行年： 2022年 
JST資料番号： U7071A  ISSN： 1664-8021  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： ヒト催奇形物質としてのZikaウイルスの同定の5年後に,先天性Zika症候群(CZS)と呼ばれる早期臨床症状をレビューした。CZSの子供は,運動,認知および言語発達ドメインで極めて低いパフォーマンスで,非常に悪い予後を有し,実際には,脳性麻痺の重症型を特徴とする。しかし,これらの徴候は氷山の先端であり,いくつかの子供は軽度の形の欠損を示す。さらに,神経発達は脳または眼異常なしで生まれた非微小脳小児の大部分で正常範囲である。母性感染が妊娠第2半に起こるとき,脳の発達における垂直伝達および結果として生じる破壊は,はるかに頻度が低い。実験的研究は,出生前感染小児および出生後および成人感染の両方で,他の行動結果の可能性に警告した。補因子はCZSの開発において重要な役割を果たし,遺伝的,環境的,栄養的および社会的決定因子を含み,症例の非対称分布をもたらす。これらの社会的変数のいくつかはまた,学際的専門的治療へのアクセスを制限する。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 脳 ,  遺伝 ,  *子宮 ,  成長 ,  てんかん ,  妊娠 ,  ヒト ,  子供 ,  小頭症 ,  症状 ,  脳性麻痺 ,  治療法 ,  予後 ,  補因子
準シソーラス用語： 言語発達 ,  出生 ,  *神経発生 , 【Automatic Indexing@JST】

著者キーワード (6件)： 小頭症 ,  ジカ(ZIKV) ,  てんかん ,  脳性麻痺 ,  神経発達 ,  眼

分類 (2件)： 先天性疾患・奇形一般  (GD03010V) ,  神経系の疾患  (GN03000O)

引用文献 (164件)：

• Abtibol-BernardinoM. R., de Almeida PeixotoL. d. F. A., de OliveiraG. A., de AlmeidaT. F., RodriguesG. R. I., OtaniR. H., et al (2020). Neurological Findings in Children without Congenital Microcephaly Exposed to Zika Virus In Utero: A Case Series Study. Viruses 12 (11), 1335. doi: 10.3390/v12111335
• Adams WaldorfK. M., Stencel-BaerenwaldJ. E., KapurR. P., StudholmeC., BoldenowE., VornhagenJ., et al (2016). Fetal Brain Lesions after Subcutaneous Inoculation of Zika Virus in a Pregnant Nonhuman Primate. Nat. Med. 22, 1256-1259. doi: 10.1038/nm.4193
• Adams-WaldorfK. M., OlsonE. M., NelsonB. R., LittleM.-T. E., RajagopalL. (2018). The Aftermath of Zika: Need for Long-Term Monitoring of Exposed Children. Trends Microbiology 26 (9), 729-732. doi: 10.1016/j.tim.2018.05.011
• AdebanjoT., Godfred-CatoS., ViensL., FischerM., StaplesJ. E., Kuhnert-TallmanW., et al (2017). Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection - United States, October 2017. MMWR Morb Mortal Wkly Rep. 66 (41), 1089-1099. doi: 10.15585/mmwr.mm6641a1
• AdesA. E., BrickleyE. B., AlexanderN., BrownD., JaenischT., Miranda-FilhoD. d. B., et al (2020). Zika Virus Infection in Pregnancy: a Protocol for the Joint Analysis of the Prospective Cohort Studies of the ZIKAlliance, ZikaPLAN and ZIKAction Consortia. BMJ open 10 (12), e035307. doi: 10.1136/bmjopen-2019-035307

タイトルに関連する用語 (6件)： 子宮 ,  曝露 ,  小児 ,  神経発達 ,  臨床 ,  分子