文献

J-GLOBAL ID：202202246454118420   整理番号：22A0432443

メタゲノミクス解析は双極性うつ病における診断および治療転帰予測のための腸内細菌シグネチャを明らかにする【JST・京大機械翻訳】

Metagenomic analysis reveals gut bacterial signatures for diagnosis and treatment outcome prediction in bipolar depression

著者 (43件)： Lai Jianbo (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Lai Jianbo (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Lai Jianbo (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Li Ang (Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) ,  Jiang Jiajun (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Yuan Xiuxia (Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) ,  Zhang Peifen (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Xi Caixi (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Wu Lingling (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Wang Zheng (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Wang Zheng (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Wang Zheng (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Chen Jingkai (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Chen Jingkai (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Chen Jingkai (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Lu Jing (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Lu Jing (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Lu Jing (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Lu Shaojia (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Lu Shaojia (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Lu Shaojia (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Mou Tingting (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Mou Tingting (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Mou Tingting (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Zhou Hetong (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Zhou Hetong (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Zhou Hetong (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Wang Dandan (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Wang Dandan (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Wang Dandan (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Huang Manli (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Huang Manli (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Huang Manli (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Dong Fengqin (Department of Endocrinology and Metabolism, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Li Ming D. (State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Xu Yi (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Xu Yi (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Xu Yi (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Song Xueqin (Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) ,  Hu Shaohua (Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) ,  Hu Shaohua (The Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China) ,  Hu Shaohua (Brain Research Institute of Zhejiang University, Hangzhou 310003, China) ,  Hu Shaohua (The MOE Frontier Science Center for Brain Science & Brain-machine Integration, Zhejiang University, Hangzhou 310058, China)
資料名： Psychiatry Research  (Psychiatry Research)
巻： 307  ページ： Null  発行年： 2022年 
JST資料番号： A1184A  ISSN： 0165-1781  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： クエチアピン単剤療法後の双極性障害(BD)のうつ病患者における腸微生物変化を特性化し,疾患診断および転帰予測の可能性を検討した。糞便試料は60名の健常人と62名の急性抑鬱エピソード患者から得た。すべての患者は登録後に1か月のクエチアピン治療を受けた。腸微生物叢の構造をメタゲノム配列決定で測定し,静止状態機能的磁気共鳴画像法で示される臨床プロファイルと脳機能との相関を分析した。細菌種に基づくランダム森林モデルを,それぞれ対照から患者と非応答者からの応答者を区別するために構築した。BD患者は腸の微生物多様性と組成に特異的変化を示した。クエチアピン処理は微生物群集の多様性を増加させ,組成を変化させた。Clostridium bartletiiの豊度は年齢,ベースライン鬱病重症度と負に相関し,海馬における自然神経振動と正の関連があった。(1)患者と対照と(2)応答者と非応答者に対する樹木ベースの分類モデルは,それぞれ0.733と0.800の曲線下面積を示した。著者らの知見は,BDにおける腸ジストロフィーに関する既存の文献への新たな証拠を加え,疾患診断および治療転帰予測に対する微生物ベースのバイオマーカーの可能性を明らかにした。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 微生物 ,  *細菌 ,  双極性障害 ,  海馬 ,  Clostridium ,  *うつ病 ,  ミクロフローラ ,  抑うつ ,  バイオマーカー
準シソーラス用語： *双極性うつ病 ,  *腸内細菌 ,  *メタゲノミクス ,  メタゲノム ,  微生物多様性 , 【Automatic Indexing@JST】

著者キーワード (5件)： 双極性障害 ,  腸内微生物相 ,  クエチアピン ,  メタゲノミクス ,  機能性磁気共鳴イメージング

分類 (2件)： 精神障害の薬物療法  (GR04020D) ,  向精神薬の臨床への応用  (GW03110J)

物質索引 (1件)： クエチアピン

タイトルに関連する用語 (9件)： メタゲノミクス ,  解析 ,  双極性うつ病 ,  診断 ,  治療 ,  転帰 ,  予測 ,  腸内細菌 ,  シグネチャ