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J-GLOBAL ID：202202247912130912   整理番号：22A0429086

幼児における出産前および幼児期の複数金属曝露と神経発達との関連:前向きコホート研究【JST・京大機械翻訳】

Association of both prenatal and early childhood multiple metals exposure with neurodevelopment in infant: A prospective cohort study

著者 (29件)： Liu Chaoqun (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Liu Chaoqun (Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Liu Chaoqun (Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, Guangxi, China) ,  Huang Lulu (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Huang Lulu (Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, Guangxi, China) ,  Huang Lulu (Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Huang Shengzhu (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Wei Luyun (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Cao Dehao (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Zan Gaohui (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Zan Gaohui (Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Tan Yanli (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Tan Yanli (Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Wang Sida (Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China) ,  Yang Minjing (Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China) ,  Tian Long (Department of Science and Education, Maternal & Child Health Hospital of Qinzhou, Qinzhou, Guangxi, China) ,  Tang Weijun (Center for Translational Medicine, Maternal & Child Health Hospital of Qinzhou, Qinzhou, Guangxi, China) ,  He Caitong (Department of Science and Education, Maternal & Child Health Hospital of Yulin, Yulin, Guangxi, China) ,  Shen Chunhua (Liuzhou Maternity and Child Healthcare Hospital, Liuzhou Institute of Reproduction and Genetics, Affiliated Maternity Hospital and Affiliated Children’s Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi, China) ,  Luo Bangzhu (Department of Medical Services Section, Maternal & Child Health Hospital of Guigang, Guigang, Guangxi, China) ,  Zhu Maoling (Department of Obstetrics, Maternal & Child Health Hospital of Nanning, Nanning, Guangxi, China) ,  Liang Tao (Department of Pediatrics, Maternal & Child Health Hospital of Wuzhou, Wuzhou, Guangxi, China) ,  Pang Baohong (Department of Women Health Care, Maternal & Child Health Hospital of Yuzhou, Yulin, Guangxi, China) ,  Li Mujun (Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China) ,  Mo Zengnan (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Mo Zengnan (Department of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, China) ,  Yang Xiaobo (Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, China) ,  Yang Xiaobo (Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, Guangxi, China) ,  Yang Xiaobo (Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China)
資料名： Environmental Research  (Environmental Research)
巻： 205  ページ： Null  発行年： 2022年 
JST資料番号： D0574A  ISSN： 0013-9351  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 小児の神経発達障害は,増大する公衆の懸念となっている。しかしながら,金属曝露と神経認知機能の間の関係は,大部分が不明のままである。2~3歳児の神経発達に対する妊娠中および小児期の複数の金属曝露の関連性を系統的に評価した。Guangxi Birth Cohort Studyから703の母子ペア間の血清と尿中の22の金属を測定した。子供の神経認知発達を,Gesell発達診断尺度(GDDS;中国人版)により評価した。多重線形回帰モデルを用いて,金属(弾性ネット回帰により選択した)と結果の間の関係を評価した。Bayesカーネルマシン回帰(BKMR)を用いて,多重金属混合物と結果の間の可能な結合効果を評価した。出生前のアルミニウム(Al)曝露は,多金属モデルにおいて,微細な運動発達指数(DQ)(β=-1.545,95%CI:2.231,-0.859),適応DQ(β=-1.182,95%CI:1.632,-0.732),言語DQ(β=-1.284,95%CI:1.758,-0.809)および社会的DQ(β=-1.729,95%CI:2.406,-1.052)と負の関係があった。出産前カドミウム(Cd)曝露は総運動DQ(β=-2.524,95%CI:4.060,-0.988)と負に相関したが,分娩後Cd曝露は言語DQと負相関した(β=-1.678,95%CI:3.227,-0.129)。層別解析では,異なる性別の乳児は金属曝露に対して異なる感受性を有し,神経行動発達は第1および第2三半期における金属曝露により有意に影響された。BKMR分析は,言語DQスコアに対するAl,Cdおよびセレン(Se)の負の関節効果を明らかにした;分娩後のCd曝露はこの関係で主要な役割を果たした。Al,Ba,Cd,モリブデン(Mo),鉛(Pb),アンチモン(Sb),およびストロンチウム(Sr)への出生前曝露,およびコバルト(Co),Cd,スタンナム(Sn),鉄(Fe),ニッケル(Ni),およびSeへの産後曝露は乳児の神経学的発達と関連する。第1と第2の三半期は,金属曝露が神経発達に影響を及ぼすとき最も敏感な期間であるかもしれない。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： カドミウム ,  言語 ,  セレン ,  重金属 ,  血清 ,  妊娠 ,  分娩 ,  層別 ,  子供 ,  乳児 ,  幼児 ,  *前向きコホート研究
準シソーラス用語： 小児期 ,  産後 ,  *出産 , 【Automatic Indexing@JST】

著者キーワード (4件)： 金属 ,  複合曝露 ,  神経発達 ,  Gesell

分類 (2件)： 疫学  (GB03000E) ,  公衆衛生  (GB02000X)

タイトルに関連する用語 (6件)： 幼児 ,  出産 ,  幼児期 ,  曝露 ,  神経発達 ,  前向きコホート研究