文献

J-GLOBAL ID：202202255018079010   整理番号：22A0481195

軽度SARS-CoV-2感染における高細胞毒性CD8+T細胞受容体の動員【JST・京大機械翻訳】

Recruitment of highly cytotoxic CD8⁺ T cell receptors in mild SARS-CoV-2 infection

著者 (43件)： Wagner Karolin I. (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Mateyka Laura M. (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Jarosch Sebastian (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Grass Vincent (Institute of Virology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Weber Simone (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Schober Kilian (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Schober Kilian (Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitaetsklinikum Erlangen, Friedrich-Alexander-Universitaet (FAU) Erlangen-Nuernberg, 91054 Erlangen, Germany) ,  Hammel Monika (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Burrell Teresa (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Kalali Behnam (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Poppert Holger (Department of Neurology, Helios Klinikum Muenchen West, 81241 Munich, Germany) ,  Poppert Holger (Neurologische Klinik, University Hospital Rechts der Isar, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Beyer Henriette (Department of Neurology, Helios Klinikum Muenchen West, 81241 Munich, Germany) ,  Schambeck Sophia (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Schambeck Sophia (Department of Neurology, Helios Klinikum Muenchen West, 81241 Munich, Germany) ,  Holdenrieder Stefan (Institute of Laboratory Medicine, Munich Biomarker Research Center, Deutsches Herzzentrum Muenchen, Technical University of Munich (TUM), 80636 Munich, Germany) ,  Strotges-Achatz Andrea (Institute of Laboratory Medicine, Munich Biomarker Research Center, Deutsches Herzzentrum Muenchen, Technical University of Munich (TUM), 80636 Munich, Germany) ,  Haselmann Verena (Department of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, 68167 Mannheim, Germany) ,  Neumaier Michael (Department of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, 68167 Mannheim, Germany) ,  Erber Johanna (Department of Internal Medicine II, University Hospital rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany) ,  Priller Alina (Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Yazici Sarah (Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Roggendorf Hedwig (Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Odendahl Marcus (Experimental Transfusion Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany) ,  Odendahl Marcus (Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, 01307 Dresden, Germany) ,  Tonn Torsten (Experimental Transfusion Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany) ,  Tonn Torsten (Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, 01307 Dresden, Germany) ,  Dick Andrea (Laboratory of Immunogenetics and Molecular Diagnostics, Department of Transfusion Medicine, Cellular Therapeutics and Hemostaseology, LMU University Hospital, 81377 Munich, Germany) ,  Witter Klaus (Laboratory of Immunogenetics and Molecular Diagnostics, Department of Transfusion Medicine, Cellular Therapeutics and Hemostaseology, LMU University Hospital, 81377 Munich, Germany) ,  Mijocevic Hrvoje (Institute of Virology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Protzer Ulrike (Institute of Virology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Protzer Ulrike (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany) ,  Knolle Percy A. (Institute of Molecular Immunology and Experimental Oncology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Knolle Percy A. (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany) ,  Pichlmair Andreas (Institute of Virology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Pichlmair Andreas (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany) ,  Crowell Claudia S. (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Crowell Claudia S. (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany) ,  Gerhard Markus (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Gerhard Markus (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany) ,  D’Ippolito Elvira (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Busch Dirk H. (Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), 81675 Munich, Germany) ,  Busch Dirk H. (German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany)
資料名： Cell Reports  (Cell Reports)
巻： 38  号： 2  ページ： Null  発行年： 2022年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： T細胞免疫は重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)感染の制御に重要であり,定量的レベルで広く研究されている。しかし,特にCD8+T細胞の応答の質は,これまでわずかにしか調べられていない。ここで,著者らは,回復個体における一般的ヒト白血球抗原(HLA)クラスI分子に限定された免疫優性SARS-CoV-2エピトープに特異的なT細胞受容体(TCR)レパートリーを単離する。SARS-CoV-2特異的CD8+T細胞を感染後12か月まで検出した。TCRレパートリーは,TCRエンジニアリングT細胞に対し示されるように,ウイルス感染細胞に対し,不均一な機能的アビディティと細胞毒性を有し,多様である。高TCR機能性は遺伝子シグネチャと相関し,各エピトープ:HLA組合せに対して検索できる。全体として,著者らのデータは,保護免疫のポリクローナルおよび高度に機能的CD8+TCRs-クラス特性が,軽度のSARS-CoV-2感染で動員され,機能的CD8+T細胞免疫の質を評価し,潜在的に回復するツールを提供することを示す。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝子 ,  *T細胞 ,  ヒト白血球抗原 ,  *細胞毒性 ,  単離 ,  細胞傷害性T細胞 ,  エピトープ ,  *CD8抗原 ,  *T細胞受容体
準シソーラス用語： CD8陽性T細胞 ,  *重症急性呼吸器症候群 ,  ウイルス感染細胞 ,  免疫優性 ,  T細胞免疫 , 【Automatic Indexing@JST】

著者キーワード (9件)： SARS-CoV-2感染 ,  温和なCOVID-19 ,  CD8+T細胞 ,  T細胞免疫 ,  T細胞受容体 ,  細胞傷害性T細胞 ,  TCR工学 ,  TCR同定 ,  scRNA配列決定

分類 (3件)： 感染免疫  (ED03030P) ,  細胞膜の受容体  (EF04030C) ,  免疫反応一般  (ED03010T)

タイトルに関連する用語 (6件)： 軽度 ,  SARS-CoV-2 ,  感染 ,  細胞毒性 ,  CD8+T細胞 ,  受容体