文献

J-GLOBAL ID：202202255677361388   整理番号：22A1181193

心筋梗塞後の心臓リモデリング:炎症と線維症に対するマイクロRNAの機能的寄与【JST・京大機械翻訳】

Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

著者 (14件)： Varzideh Fahimeh (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Varzideh Fahimeh (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States) ,  Kansakar Urna (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Kansakar Urna (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States) ,  Donkor Kwame (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Wilson Scott (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Jankauskas Stanislovas S. (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Jankauskas Stanislovas S. (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States) ,  Mone Pasquale (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Wang Xujun (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Wang Xujun (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States) ,  Lombardi Angela (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Santulli Gaetano (Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, New York, NY, United States) ,  Santulli Gaetano (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Wilf Family Cardiovascular Research Institute, Institute for Neuroimmunology and Inflammation (INI), New York, NY, United States)
資料名： Frontiers in Cardiovascular Medicine (Web)  (Frontiers in Cardiovascular Medicine (Web))
巻： 9  ページ： 863238  発行年： 2022年 
JST資料番号： U7061A  ISSN： 2297-055X  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 虚血傷害後,心臓は炎症および線維症反応を含むいくつかの段階を含む構造的および機能的リモデリングの複雑な過程を受ける。本レビューでは,心筋梗塞後の炎症と線維症の調節におけるマイクロRNAの寄与に焦点を当てた。著者らは,マイクロRNAと炎症と線維芽細胞活性化の鍵となる調節因子の間の相互作用を探索する最も最新の研究をまとめ,これらの急速に進行する分野における臨床応用を含む最近の発見について議論する。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  *心臓 ,  *炎症 ,  線維芽細胞 ,  虚血 ,  *心筋梗塞 ,  *線維症 ,  *アンチセンスRNA ,  酸化ストレス
準シソーラス用語： *マイクロRNA ,  *リモデリング ,  調節因子 ,  臨床応用 ,  *心臓リモデリング , 【Automatic Indexing@JST】

著者キーワード (8件)： 心臓リモデリング ,  臨床試験 ,  医薬品開発 ,  エピジェネティクス ,  心不全 ,  虚血性心疾患 ,  非コードRNA ,  酸化ストレス

分類 (2件)： 循環系の基礎医学  (GJ01020K) ,  心臓  (EJ04020D)

引用文献 (106件)：

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• Verjans R, Derks WJA, Korn K, Sonnichsen B, Van Leeuwen REW, Schroen B, et al Functional screening identifies microRNAs as multi-cellular regulators of heart failure. Sci Rep. (2019) 9:6055. doi: 10.1038/s41598-019-41491-9
• Gioffre S, Chiesa M, Cardinale DM, Ricci V, Vavassori C, Cipolla CM, et al Circulating microRNAs as potential predictors of anthracycline-induced troponin elevation in breast cancer patients: diverging effects of doxorubicin and epirubicin. J Clin Med. (2020) 9:1418. doi: 10.3390/jcm9051418
• Kansakar U, Varzideh F, Mone P, Jankauskas SS, Santulli G. Functional role of microRNAs in regulating cardiomyocyte death. Cells (2022) 11:983. doi: 10.3390/cells11060983
• Kehat I, Molkentin JD. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation. (2010) 122:2727-35. doi: 10.1161/CIRCULATIONAHA.110.942268

タイトルに関連する用語 (5件)： 心筋梗塞 ,  心臓リモデリング ,  炎症 ,  線維症 ,  マイクロRNA