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J-GLOBAL ID：202202256244782894   整理番号：22A0232659

ジヒドロアルテミシニンは血液から胆汁へのコレステロールおよび胆汁酸のベクター輸送を増強することにより卵巣切除マウスにおける高コレステロール血症を改善する【JST・京大機械翻訳】

Dihydroartemisinin improves hypercholesterolemia in ovariectomized mice via enhancing vectorial transport of cholesterol and bile acids from blood to bile

著者 (45件)： Lei Zili (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Lei Zili (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Lei Zili (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Wu Huijuan (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Wu Huijuan (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Wu Huijuan (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Wu Huijuan (School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China) ,  Yang Yanhong (The First Affiliated Hospital (School of Clinical Medicine), Guangdong Pharmaceutical University, Nong-Lin-Xia Road 19#, Yue-Xiu District, Guangzhou 510080, PR China) ,  Hu Qing (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Hu Qing (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Hu Qing (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Lei Yuting (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Lei Yuting (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Lei Yuting (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Liu Wanwan (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Liu Wanwan (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Liu Wanwan (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Nie Ya (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Nie Ya (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Nie Ya (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Nie Ya (School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China) ,  Yang Lanxiang (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Yang Lanxiang (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Yang Lanxiang (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Yang Lanxiang (School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China) ,  Zhang Xueying (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Zhang Xueying (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Zhang Xueying (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Zhang Xueying (School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China) ,  Yang Changyuan (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Yang Changyuan (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Yang Changyuan (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Yang Changyuan (School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China) ,  Lin Ting (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Lin Ting (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Lin Ting (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Tong Fengxue (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Tong Fengxue (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Tong Fengxue (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Zhu Jiamin (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Zhu Jiamin (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Zhu Jiamin (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China) ,  Guo Jiao (Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases...) ,  Guo Jiao (Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China) ,  Guo Jiao (Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, PR China)
資料名： Bioorganic & Medicinal Chemistry  (Bioorganic & Medicinal Chemistry)
巻： 53  ページ： Null  発行年： 2022年 
JST資料番号： W0556A  ISSN： 0968-0896  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 閉経後女性の血清中の総コレステロール(TC)と低密度リポ蛋白質コレステロール(LDL-C)濃度の増加は,世界的に高齢女性の心血管疾患の高い罹患率の重要な危険因子である。閉経後女性におけるジヒドロアルテミシニン(DHA)の抗高コレステロール血症機能を試験するために,卵巣摘出(OVX)マウスを作成し,DHAをOVXマウスに4週間投与した。血液および肝臓組織を,それぞれ生化学および組織学的試験のために採取した。肝臓または回腸におけるコレステロール,胆汁酸および脂肪酸の代謝および輸送に関連する遺伝子のmRNAおよび蛋白質発現レベルを,qPCRおよびウェスタンブロットを通してチェックした。DHAは,血清中のTCとLDL-Cの高濃度と卵巣摘出マウスの肝臓における脂質蓄積を有意に減少させることができた。ABCG5/8の発現はOVXマウスの肝臓で減少し,DHAはそれらの発現を上方制御することができた。Slc10a1,Slco1b2およびAbcb11を含む血液から胆汁への胆汁酸塩輸送に対する輸送蛋白質の遺伝子もDHAにより有意にアップレギュレートされた。DHAはまた,胆汁酸塩の吸収を減らすためにOVXマウスの回腸におけるSlc10a2の発現を下方制御した。FasnおよびCD36のような脂肪酸合成および取り込みに必要な遺伝子はOVXマウスの肝臓で低下し,DHA投与はそれらの発現をアップレギュレートした。これらの結果は,DHAが血液から胆汁へのコレステロールと胆汁酸のベクター輸送を強化することによりOVXマウスにおける高コレステロール血症を改善することを示した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 脂肪酸 ,  mRNA ,  遺伝子 ,  回腸 ,  血清 ,  *胆汁 ,  *胆汁酸 ,  *ベクター ,  *高コレステロール血症 ,  ダウンレギュレーション ,  アップレギュレーション ,  危険因子 ,  定量的PCR法 ,  ステロール ,  脂環式アルコール
準シソーラス用語： ABCG5 , 【Automatic Indexing@JST】

著者キーワード (5件)： 閉経後女性 ,  高コレステロール血症 ,  卵巣摘出マウス ,  ジヒドロアルテミシニン ,  腸肝循環

分類 (2件)： ステロイド  (CF10040O) ,  脂質代謝作用薬の基礎研究  (GW13040M)

物質索引 (1件)： コレステロール

タイトルに関連する用語 (11件)： ジヒドロアルテミシニン ,  血液 ,  胆汁 ,  コレステロール ,  胆汁酸 ,  ベクター ,  輸送 ,  増強 ,  卵巣切除 ,  マウス ,  高コレステロール血症