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J-GLOBAL ID：202202256388114754   整理番号：22A0627487

mTORC1-eIF4F軸は休止多能性を制御する【JST・京大機械翻訳】

The mTORC1-eIF4F axis controls paused pluripotency

著者 (48件)： Xu Xueting (School of Life Sciences, University of Science and Technology of China, Hefei, China) ,  Xu Xueting (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Xu Xueting (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Ahmed Tanveer (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Ahmed Tanveer (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Wang Lulu (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Wang Lulu (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Cao Xintao (Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China) ,  Zhang Zeyu (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Wang Ming (Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Biochemistry & Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China) ,  Lv Yuan (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Lv Yuan (University of Chinese Academy of Sciences, Beijing, China) ,  Lv Yuan (Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Kanwal Shahzina (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Kanwal Shahzina (Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Tariq Muqddas (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Lin Runxia (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Lin Runxia (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Lin Runxia (University of Chinese Academy of Sciences, Beijing, China) ,  Zhang Hui (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Huang Yinghua (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Huang Yinghua (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Peng Hao (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Peng Hao (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Peng Hao (University of Chinese Academy of Sciences, Beijing, China) ,  Lin Danni (School of Life Sciences, University of Science and Technology of China, Hefei, China) ,  Lin Danni (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Lin Danni (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Shi Xue (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Shi Xue (University of Chinese Academy of Sciences, Beijing, China) ,  Geng Didi (MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China) ,  Liu Baohua (Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Biochemistry & Molecular Biology, Shenzhen University Health Science Center, Shenzhen, China) ,  Zhang Xiaofei (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Zhang Xiaofei (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Zhang Xiaofei (University of Chinese Academy of Sciences, Beijing, China) ,  Yi Wen (MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou, China) ,  Qin Yan (Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China) ,  Esteban Miguel A (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Esteban Miguel A (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Esteban Miguel A (University of Chinese Academy of Sciences, Beijing, China) ,  Esteban Miguel A (Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Esteban Miguel A (Institute of Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing, China) ,  Esteban Miguel A (Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China) ,  Qin Baoming (CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Center, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou...) ,  Qin Baoming (Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China) ,  Qin Baoming (Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China) ,  Qin Baoming (University of Chinese Academy of Sciences, Beijing, China) ,  Qin Baoming (Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China)
資料名： EMBO Reports  (EMBO Reports)
巻： 23  号： 2  ページ： e53081  発行年： 2022年 
JST資料番号： W1261A  ISSN： 1469-221X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： マウス胚性幹細胞(mESCs)は,不定に自己再生し,多能性を維持することができる。キナーゼ阻害剤INK128によるラパマイシン(mTOR)の機構的標的の阻害は,従来の血清/LIF培地(SL)で培養したmESCにおいて,休止した多能性を誘導することが知られているが,基礎となる機構は不明のままである。本研究では,mTOR複合体1(mTORC1)は,SLおよび2iL培地(GSK3およびMEK阻害剤およびLIF)の両者で増殖した細胞においてmTOR阻害誘導休止多能性を仲介することを示した。また,mTORC1は,サイトゾルおよびミトコンドリアリボソームサブユニットの両方のmRNAを標的とするeIF4F仲介翻訳開始を介して,両条件で自己再生を調節することも示した。さらに,ミトコンドリア翻訳の阻害は,休止多能性を誘導するのに十分である。興味深いことに,eIF4Fはまた,SLにおいてmTORC1非依存性ではあるがMEK/ERK依存性様式で多能性の維持を調節するが,多能性遺伝子の翻訳はSLと2iLで異なって制御されていることを示す。本研究は,mTORがmESCにおける自己再生を支配する方法の詳細な描像を明らかにし,多能性調節におけるeIF4Fの文脈依存性機能を明らかにする。Copyright 2022 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： mRNA ,  遺伝子 ,  血清 ,  細胞 ,  ミトコンドリア ,  汎用性 ,  サイトゾル ,  *翻訳【遺伝】 ,  *セリン/トレオニンキナーゼ
準シソーラス用語： グリコーゲンシンターゼキナーゼ3 ,  MEK阻害剤 ,  自己再生 ,  リボソームサブユニット ,  *mTORC1 ,  マウスES細胞 ,  翻訳開始 , 【Automatic Indexing@JST】

著者キーワード (5件)： eIF4F ,  ミトコンドリア翻訳 ,  mTORC1 ,  多能性 ,  自己更新

分類 (2件)： 細胞生理一般  (EF02010S) ,  発生と分化  (EJ16020W)

タイトルに関連する用語 (4件)： mTORC1 ,  eIF4F ,  休止 ,  多能性