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J-GLOBAL ID：202202256423559046   整理番号：22A1022817

IVF妊娠における生存中のシングルトンの周産期転帰に対する消失双生児の影響【JST・京大機械翻訳】

The Influence of the Vanishing Twin on the Perinatal Outcome of Surviving Singleton in IVF Pregnancy

著者 (56件)： Li Jiarong (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Li Jiarong (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Li Jiarong (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Li Jiarong (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Li Jiarong (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Li Jiarong (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Li Jingyu (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Li Jingyu (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Li Jingyu (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Li Jingyu (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Li Jingyu (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Li Jingyu (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Zhang Yiyuan (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Zhang Yiyuan (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Zhang Yiyuan (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Zhang Yiyuan (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Zhang Yiyuan (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Zhang Yiyuan (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Hu Kuona (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Hu Kuona (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Hu Kuona (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Hu Kuona (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Hu Kuona (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Hu Kuona (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Chen Na (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Chen Na (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Chen Na (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Chen Na (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Chen Na (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Chen Na (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Gao Jie (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Gao Jie (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Gao Jie (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Gao Jie (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Gao Jie (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Gao Jie (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Hu Jingmei (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Hu Jingmei (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Hu Jingmei (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Hu Jingmei (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Hu Jingmei (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Hu Jingmei (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Cui Linlin (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Cui Linlin (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Cui Linlin (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Cui Linlin (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Cui Linlin (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Cui Linlin (7Center for Reproductive Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Chen Zi-Jiang (1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China) ,  Chen Zi-Jiang (2Research Unit of Gametogenesis and Health of Assisted Reproductive Technology (ART)-Offspring, Chinese Academy of Medical Sciences, Jinan, China) ,  Chen Zi-Jiang (3Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China) ,  Chen Zi-Jiang (4Shandong Key Laboratory of Reproductive Medicine, Jinan, China) ,  Chen Zi-Jiang (5Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, China) ,  Chen Zi-Jiang (6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China) ,  Chen Zi-Jiang (8Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Chen Zi-Jiang (9Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China)
資料名： Frontiers in Endocrinology (Web)  (Frontiers in Endocrinology (Web))
巻： 13  ページ： 832665  発行年： 2022年 
JST資料番号： U7068A  ISSN： 1664-2392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 目的:本研究の目的は,生存単胎における周産期転帰に対する消失双晶(VT)の影響を明らかにし,さらに感受性窓を同定することであった。研究デザイン:後向きコホート研究。方法:消失した共双晶と11,148人の単胎対照群の合計636人の生存者を登録した。曝露群は,さらに早期VT(EVT,VT≦13週,N=593)および後期VT亜群(LVT,VT>13週,N=43)に,双晶消失の在胎齢に従って分割された。すべての参加者は,in vitro受精(IVF)を通して考案された。妊娠期間,出生体重および早産(PTB)の発生率,低出生体重(LBW),妊娠年齢(SGA),新生児集中治療室(NICU)入院,臍帯異常,新生児の黄疸,および乏血羊水を含む周産期転帰を群間で比較した。結果:著者らの出生コホートにおいて,全単胎分娩の約5.4%は,消滅双晶妊娠から発生した。単胎と比較して,初期および後期VT妊娠は,有意に低い出生体重(3337.57±532.24gおよび2916.05±526.07g対3446.15±526.07g;p<0.001およびp<0.001),より頻繁な新生児黄疸(47.0%および60.5%対40.6%;p=0.002およびp=0.008),および臍帯異常の発生率の減少(15.5%および7.0%対19.9%;p=0.009およびp=0.034)を示した。初期VT群の新生児は,SGA(5.4%対3.6%,p=0.002)として現れ,原発性単胎より乏血性羊水症(5.4%対3.4%;p=0.008)に罹患した。加えて,後期VT生存者の在胎齢は,対照のそれより短く(37.25±3.25対39.04±1.63,p=0.001),PTBの有意に高いリスク(30.2%対6.6%;p<0.001)とNICU入院(27.9%対9.4%,p<0.001)があった。SGAを除くすべての違いは,母親の年齢,BMI,およびパリティの調整後に有意性を維持する。結論:消失した共-双晶を有する単胎は,元の単胎と比較してより悪い周産期転帰を示し,LVT負荷は生存の1つでも非常に高かった。したがって,周産期における密接なモニタリングは,このタイプの新生児において示唆された。さらに,選択的単一胚移植は,その根で問題に取り組むことができる完全に考慮されるべきである。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 双晶 ,  黄疸 ,  新生児 ,  *妊娠 ,  分娩 ,  虚血 ,  *双生児 ,  羊水 ,  新生児黄疸 ,  疫学 ,  *周産期 ,  体外受精 ,  in vitro実験
準シソーラス用語： 出生体重 ,  生存者 ,  出生コホート , 【Automatic Indexing@JST】

著者キーワード (5件)： 体外受精-妊娠 ,  消滅する双子 ,  周産期の転帰 ,  生殖補助技術(ART) ,  子孫

分類 (2件)： 循環系の疾患  (GJ03000C) ,  循環系疾患の治療一般  (GJ05010B)

引用文献 (31件)：

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• Adamson GD, Norman RJ. Why are Multiple Pregnancy Rates and Single Embryo Transfer Rates So Different Globally, and What do We do About it? Fertil Steril (2020) 114:680-9. doi: doi: 10.1016/j.fertnstert.2020.09.003
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タイトルに関連する用語 (6件)： IVF ,  妊娠 ,  生存 ,  周産期 ,  転帰 ,  双生児