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J-GLOBAL ID：202202257826211059   整理番号：22A0314953

免疫優性NP105-113-B*07:02細胞傷害性T細胞応答はウイルス複製を制御し,重度のCOVID-19疾患と関連する【JST・京大機械翻訳】

An immunodominant NP_105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

著者 (115件)： Peng Yanchun (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Peng Yanchun (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Felce Suet Ling (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Felce Suet Ling (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Felce Suet Ling (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dong Danning (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Dong Danning (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Dong Danning (CAMS Key Laboratory of Tumor Immunology and Radiation Therapy, Xinjiang Tumor Hospital, Xinjiang Medical University, Urumqi, China) ,  Penkava Frank (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK) ,  Mentzer Alexander J. (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Mentzer Alexander J. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Yao Xuan (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Yao Xuan (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Guihai (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Liu Guihai (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Guihai (Beijing You’an Hospital, Capital Medical University, Beijing, China) ,  Yin Zixi (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Yin Zixi (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Yin Zixi (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Chen Ji-Li (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Chen Ji-Li (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Lu Yongxu (Department of Pathology, University of Cambridge, Cambridge, UK) ,  Wellington Dannielle (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Wellington Dannielle (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Wing Peter A. C. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Wing Peter A. C. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dominey-Foy Delaney C. C. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Dominey-Foy Delaney C. C. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Jin Chen (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Jin Chen (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Wang Wenbo (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Wang Wenbo (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Hamid Megat Abd (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Hamid Megat Abd (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Fernandes Ricardo A. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Fernandes Ricardo A. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Wang Beibei (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Wang Beibei (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Fries Anastasia (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Fries Anastasia (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Zhuang Xiaodong (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Ashley Neil (Single Cell Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Rostron Timothy (Sequencing Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Waugh Craig (Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Sopp Paul (Flow Cytometry Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Hublitz Philip (Genome Engineering Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Beveridge Ryan (Virus Screening Facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Tan Tiong Kit (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Dold Christina (Oxford Vaccine Group, Department of Paediatrics, and NIHR Oxford Biomedical Research Centre, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK) ,  Kwok Andrew J. (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Kwok Andrew J. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Rich-Griffin Charlotte (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Dejnirattisa Wanwisa (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Dejnirattisa Wanwisa (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Liu Chang (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Liu Chang (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Liu Chang (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Kurupati Prathiba (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Nassiri Isar (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Nassiri Isar (Department of Oncology, University of Oxford, Oxford, UK) ,  Nassiri Isar (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Watson Robert A. (Department of Oncology, University of Oxford, Oxford, UK) ,  Watson Robert A. (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Tong Orion (Department of Oncology, University of Oxford, Oxford, UK) ,  Tong Orion (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Taylor Chelsea A. (Department of Oncology, University of Oxford, Oxford, UK) ,  Taylor Chelsea A. (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Kumar Sharma Piyush (Department of Oncology, University of Oxford, Oxford, UK) ,  Kumar Sharma Piyush (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Sun Bo (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Curion Fabiola (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Curion Fabiola (Helmholtz Center Munich-German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany) ,  Revale Santiago (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Garner Lucy C. (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Garner Lucy C. (Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Jansen Kathrin (Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK) ,  Ferreira Ricardo C. (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Attar Moustafa (Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK) ,  Fry Jeremy W. (ProImmune Limited, Oxford, UK) ,  Russell Rebecca A. (Sir William Dunn School of Pathology, University of Oxford, Oxford, UK) ,  COMBAT Consortium ,  Stauss Hans J. (Institute of Immunity and Transplantation, University College London, London, UK) ,  James William (James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK) ,  Townsend Alain (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Townsend Alain (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Ho Ling-Pei (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Klenerman Paul (Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Klenerman Paul (Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Mongkolsapaya Juthathip (Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriaj Hospital, Mahidol Univ.versity, Bangkok, Thailand) ,  Screaton Gavin R. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Screaton Gavin R. (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Screaton Gavin R. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dendrou Calliope (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Sansom Stephen N. (Kennedy Institute for Rheumatology, University of Oxford, Oxford, UK) ,  Bashford-Rogers Rachael (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Chain Benny (Division of Infection and Immunity, University College London, London, UK) ,  Smith Geoffrey L. (Department of Pathology, University of Cambridge, Cambridge, UK) ,  McKeating Jane A. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  McKeating Jane A. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Fairfax Benjamin P. (Department of Oncology, University of Oxford, Oxford, UK) ,  Fairfax Benjamin P. (MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK) ,  Bowness Paul (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK) ,  McMichael Andrew J. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  McMichael Andrew J. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Ogg Graham (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Ogg Graham (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Knight Julian C. (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Knight Julian C. (Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK) ,  Knight Julian C. (Nuffield Department of Medicine, University of Oxford, Oxford, UK) ,  Dong Tao (MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) ,  Dong Tao (Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK) ,  Dong Tao (Nuffield Department of Medicine, University of Oxford, Oxford, UK)
資料名： Nature Immunology  (Nature Immunology)
巻： 23  号： 1  ページ： 50-61  発行年： 2022年 
JST資料番号： W1330A  ISSN： 1529-2908  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： NP_105-113-B*07:02特異的CD8+T細胞応答は,SARS-CoV-2感染個体で最も優勢であると考えられている。軽度の疾患とこの反応の強い関連性を見出した。NP_105-113-B*07:02特異的T細胞クローンおよび単一細胞配列決定の分析を,in vitro SARS-CoV-2感染系を用い評価した機能的アビディティおよび抗ウイルス効果と同時に行い,T細胞受容体使用,トランスクリプトームシグネチャおよび疾患重症度(急性n=77,回復n=52)と相関させた。COVID-19疾患進行におけるNP_105-113-B*07:02特異的T細胞の有益な関連を示し,T細胞前駆体の拡大,高い機能的アビディティおよび抗ウイルスエフェクター機能と関連していた。広範な免疫記憶プールは感染後に狭くなったが,NP_105-113-B*07:02-特異的T細胞は,SARS-CoV-2 Victoria株に対する抗ウイルス効果の保存およびα,β,γおよびDelta変異体の感染の6か月後に維持された。著者らのデータは,NP_105-113-B*07:02特異的T細胞応答が,軽度の疾患と高い抗ウイルス効果と関連し,将来のワクチン設計への包含を示していることを示す。Pengらは,NP_105-113-B*07:02に特異的な免疫優性細胞傷害性Tリンパ球(CTLs)が,COVID-19重症度の低下と関連することを見出した。機構的に,NP_105-113-B*07:02特異的CTLは強力な抗ウイルス機能を示し,合理的なT細胞ワクチン標的を示す可能性がある。Copyright The Author(s) 2021 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 抗ウイルス作用 ,  免疫反応 ,  ワクチン ,  *T細胞 ,  *ウイルス複製 ,  前駆体 ,  クローン ,  *細胞傷害性T細胞 ,  in vitro実験 ,  CD8抗原 ,  T細胞受容体 ,  トランスクリプトーム
準シソーラス用語： 疾患進行 ,  免疫記憶 ,  単一細胞 ,  *T細胞応答 , 【Automatic Indexing@JST】

分類 (1件)： 免疫反応一般  (ED03010T)

タイトルに関連する用語 (5件)： 免疫優性 ,  細胞傷害性T細胞 ,  応答 ,  ウイルス複製 ,  疾患