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J-GLOBAL ID：202202257987932235   整理番号：22A0922513

TFEBはオートファジー-リソソーム融合のアップレギュレーションを介してPBDE-47により誘導されるオートファジーフラックス障害を改善する【JST・京大機械翻訳】

TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion

著者 (19件)： Tang Huayang (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Tang Huayang (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Huang Haoying (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Wang Dan (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Wang Dan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Li Pei (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Li Pei (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Tian Zhiyuan (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Tian Zhiyuan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Li Dongjie (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Li Dongjie (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Wang Sumei (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Wang Sumei (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Ma Rulin (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Ma Rulin (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Xia Tao (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Xia Tao (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...) ,  Wang Aiguo (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China) ,  Wang Aiguo (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republi...)
資料名： Journal of Hazardous Materials  (Journal of Hazardous Materials)
巻： 430  ページ： Null  発行年： 2022年 
JST資料番号： B0362A  ISSN： 0304-3894  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 広く使用されている臭素化難燃剤である2,2′,4,4′-テトラブロモジフェニルエーテル(PBDE-47)はオートファジー障害と関連する顕著な神経毒性を有する。しかし,機構は不明である。結果は,PBDE-47がリソソーム生合成を損傷し,in vivoとin vitroの両方でオートファジー-リソソーム融合を妨害することを示した。著者らの研究は,PBDE-47がTFEB発現をダウンレギュレートし,TFEBの核移行を阻害することを示した。PC12細胞におけるTFEBのノックダウンはリソソーム関連蛋白質の減少とオートファジー-リソソーム融合に関与するSTX17-SNAP29-VAMP8蛋白質の発現を増加させた。逆に,in vitroでの過剰発現TFEBはリソソーム豊度を有意に改善し,オートファゴソーム-リソソーム融合阻害を改善し,オートファジーフラックスを回復させ,PC12細胞の生存を改善した。さらに,TFEBはTFEB過剰発現の誘導または誘導によりSTX17と生物学的に相互作用した。まとめると,著者らの結果は,PBDE-47によって損なわれるオートファジーフラックスがオートファゴソームとリソソームの不完全な融合に関連することを示す。TFEBは,PBDE-47発生神経毒性の将来の研究のための有望な分子標的として役立つ可能性がある。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  生合成 ,  タンパク質 ,  *リソソーム ,  神経毒性 ,  *アップレギュレーション ,  in vitro実験 ,  PC12細胞 ,  *オートファジー
準シソーラス用語： 核内移行 ,  オートファゴソーム ,  分子標的 ,  過剰発現 ,  *TFEB , 【Automatic Indexing@JST】

著者キーワード (5件)： オートファゴソーム-リソソーム融合 ,  22′ 44′-テトラブロモジフェニルエーテル ,  STX17 ,  転写因子EB ,  神経毒性

分類 (2件)： その他の汚染原因物質  (SB05040W) ,  人間に対する影響  (EE05050C)

タイトルに関連する用語 (8件)： TFEB ,  オートファジー ,  リソソーム ,  融合 ,  アップレギュレーション ,  PBDE-47 ,  誘導 ,  障害