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J-GLOBAL ID：202202258628213627   整理番号：22A0313818

長鎖非コードRNA SAMMONはブドウ膜黒色腫細胞の生存に必須である【JST・京大機械翻訳】

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

著者 (56件)： Dewaele Shanna (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Dewaele Shanna (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Dewaele Shanna (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Delhaye Louis (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Delhaye Louis (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Delhaye Louis (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Delhaye Louis (Center for Medical Biotechnology, VIB-Ghent University, Ghent, Belgium) ,  De Paepe Boel (Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium) ,  de Bony Eric James (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  de Bony Eric James (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  de Bony Eric James (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  De Wilde Jilke (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  De Wilde Jilke (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  De Wilde Jilke (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  De Wilde Jilke (Department of pathology, Ghent University Hospital, Ghent, Belgium) ,  Vanderheyden Katrien (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Vanderheyden Katrien (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Vanderheyden Katrien (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Anckaert Jasper (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Anckaert Jasper (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Anckaert Jasper (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Yigit Nurten (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Yigit Nurten (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Yigit Nurten (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Nuytens Justine (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Nuytens Justine (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Nuytens Justine (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Vanden Eynde Eveline (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Vanden Eynde Eveline (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Vanden Eynde Eveline (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Smet Joel (Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium) ,  Verschoore Maxime (Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium) ,  Nemati Fariba (Institut Curie, Laboratory of Preclinical Investigation, Translational Research Department, PSL Research University, Paris, France) ,  Decaudin Didier (Institut Curie, Laboratory of Preclinical Investigation, Translational Research Department, PSL Research University, Paris, France) ,  Decaudin Didier (Institut Curie, Department of Medical Oncology, PSL Research University, Paris, France) ,  Rodrigues Manuel (Institut Curie, Department of Medical Oncology, PSL Research University, Paris, France) ,  Rodrigues Manuel (Inserm U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisee par la Ligue Nationale Contre le Cancer, Institut Curie, PSL Research University, Paris, France) ,  Zhao Peihua (Center for Medical Biotechnology, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium) ,  Zhao Peihua (Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium) ,  Jochemsen Aart (Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands) ,  Leucci Eleonora (Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium) ,  Leucci Eleonora (TRACE, LKI Leuven Cancer Institute, Leuven, Belgium) ,  Vandesompele Jo (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Vandesompele Jo (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Vandesompele Jo (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Van Dorpe Jo (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Van Dorpe Jo (Department of pathology, Ghent University Hospital, Ghent, Belgium) ,  Marine Jean-Christophe (Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium) ,  Marine Jean-Christophe (Laboratory for Molecular Cancer Biology, Department of Oncology, KULeuven, Leuven, Belgium) ,  Van Coster Rudy (Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium) ,  Eyckerman Sven (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Eyckerman Sven (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium) ,  Eyckerman Sven (Center for Medical Biotechnology, VIB-Ghent University, Ghent, Belgium) ,  Mestdagh Pieter (OncoRNALab, Center for Medical Genetics (CMGG), Ghent University, Ghent, Belgium) ,  Mestdagh Pieter (Cancer Research Institute Ghent (CRIG), Ghent, Belgium) ,  Mestdagh Pieter (Department of Biomolecular Medicine, Ghent University, Ghent, Belgium)
資料名： Oncogene  (Oncogene)
巻： 41  号： 1  ページ： 15-25  発行年： 2022年 
JST資料番号： T0406A  ISSN： 0950-9232  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 長鎖非コードRNA(lncRNA)は,細胞型および癌型特異的発現プロファイルを示し,治療標的として非常に魅力的である。Pan-癌RNA配列決定データは,成人における最も一般的な原発性眼内悪性腫瘍であるuval黒色腫(UM)におけるSAMMSON lncRNAの広範な発現を明らかにした。現在,転移性疾患を有するUM患者に対して有効な治療法はなく,6~12か月の生存期間中央値をもたらす。UMにおけるSAMMSON阻害の治療可能性を検討した。アンチセンスオリゴヌクレオチド(ASO)仲介SAMMSON阻害は,ブドウ膜黒色腫細胞株の遺伝学的に多様なパネルの増殖と生存能を障害した。これらの効果は,アポトーシスの誘導を伴い,皮下ASOデリバリーを介して2つのuval黒色腫患者由来異種移植(PDX)モデルで再現された。SAMMSONプルダウンは,ミトコンドリア翻訳に関与する種々の蛋白質を含むいくつかの候補相互作用パートナーを明らかにした。その結果,SAMMSONの阻害は,ブドウ膜黒色腫細胞における全体的,ミトコンドリア及びサイトゾル蛋白質翻訳レベル及びミトコンドリア機能を損なった。本研究は,SAMMSON発現がuval黒色腫細胞生存に必須であることを示した。SAMMSONのASO仲介サイレンシングは,原発性および転移性のuval黒色腫患者を治療するための効果的な治療戦略を提供する可能性がある。Copyright The Author(s) 2021. corrected publication 2021 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  *RNA【核酸】 ,  タンパク質 ,  ミトコンドリア ,  異種移植 ,  サイトゾル ,  *黒色腫 ,  治療計画 ,  アポトーシス ,  遺伝子サイレンシング
準シソーラス用語： アンチセンスオリゴヌクレオチド ,  細胞生存 ,  悪性腫瘍 ,  治療標的 ,  ミトコンドリア機能 , 【Automatic Indexing@JST】

分類 (3件)： 眼の腫よう  (GP04000B) ,  腫ようの化学・生化学・病理学  (GE02030N) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (4件)： 長鎖非コードRNA ,  ブドウ膜黒色腫 ,  細胞 ,  生存