文献

J-GLOBAL ID：202202258821390687   整理番号：22A1121007

PPARデルタ活性化は,ヒト多能性幹細胞由来心筋細胞の代謝および収縮成熟を誘導する【JST・京大機械翻訳】

PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes

著者 (36件)： Wickramasinghe Nadeera M. (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Wickramasinghe Nadeera M. (Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Wickramasinghe Nadeera M. (Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sachs David (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Shewale Bhavana (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Shewale Bhavana (Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Shewale Bhavana (Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gonzalez David M. (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gonzalez David M. (Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Gonzalez David M. (Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Dhanan-Krishnan Priyanka (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Torre Denis (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  LaMarca Elizabeth (Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  LaMarca Elizabeth (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Raimo Serena (Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA) ,  Dariolli Rafael (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Serasinghe Madhavika N. (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Mayourian Joshua (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sebra Robert (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Beaumont Kristin (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Iyengar Srinivas (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Iyengar Srinivas (Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  French Deborah L. (Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA) ,  Hansen Arne (University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany) ,  Eschenhagen Thomas (University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany) ,  Chipuk Jerry E. (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Sobie Eric A. (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Jacobs Adam (Department of Obstetrics and Gynecology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Akbarian Schahram (Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Akbarian Schahram (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Ischiropoulos Harry (Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA) ,  Ma’ayan Avi (Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Houten Sander M. (Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Costa Kevin (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Dubois Nicole C. (Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Dubois Nicole C. (Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)
資料名： Cell Stem Cell  (Cell Stem Cell)
巻： 29  号： 4  ページ： 559-576.e7  発行年： 2022年 
JST資料番号： W3106A  ISSN： 1934-5909  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 多能性幹細胞由来心筋細胞(PSC-CM)は,ヒト心臓発生と疾患を研究するための前例のない機会を提供するが,それらは機能的および構造的に未成熟である。ここでは,代謝経路調節を介し,効率的なヒトPSC-CM(hPSC-CM)成熟を誘導する。特に,ペルオキシソーム増殖因子関連受容体(PPAR)シグナル伝達がイソ型特異的様式で解糖と脂肪酸酸化(FAO)を調節することを見出した。PPARα(PPARa)はhPSC-CMにおける最も活性なイソ型であるが,PPARδ(PPARd)活性化はFAOの根底にある遺伝子調節ネットワークを効率的にアップレギュレートし,ミトコンドリアとペルオキシソーム含量を増加させ,ミトコンドリアクリステ形成を増強し,FAOフラックスを増強する。PPARd活性化は,さらに二核化を増加させ,筋原線維組織を増強し,収縮性を改善する。hPSC-CM精製にしばしば用いられる一過性乳酸曝露は,独立した心臓成熟プログラムを誘導するが,PPARd活性化と組み合わせると,酸化的代謝をまだ増強する。要約すると,hPSC-CMにおける複数の代謝修飾を調べ,hPSC-CMにおける解糖からFAOへの代謝スイッチの誘導におけるPPARdシグナル伝達の役割を同定した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 酸化 ,  心臓 ,  解糖 ,  筋原線維 ,  *代謝 ,  ヒト ,  ミトコンドリア ,  代謝経路 ,  ペルオキシソーム ,  *幹細胞 ,  細胞情報伝達 ,  *心筋細胞 ,  PPARα ,  *PPAR【受容体】 ,  *多能性幹細胞
準シソーラス用語： 脂肪酸酸化 , 【Automatic Indexing@JST】

著者キーワード (5件)： 幹細胞 ,  代謝 ,  心臓成熟 ,  脂肪酸酸化 ,  PPARシグナリング

分類 (2件)： 細胞生理一般  (EF02010S) ,  循環系の基礎医学  (GJ01020K)

タイトルに関連する用語 (9件)： PPARデルタ ,  活性化 ,  ヒト ,  多能性幹細胞 ,  心筋細胞 ,  代謝 ,  収縮 ,  成熟 ,  誘導