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J-GLOBAL ID：202202260446643352   整理番号：22A1179143

小児における湿疹と注意欠陥多動性障害症状との関連【JST・京大機械翻訳】

Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children

著者 (46件)： Loo Evelyn Xiu Ling (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Loo Evelyn Xiu Ling (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Loo Evelyn Xiu Ling (Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Ooi Delicia Shu Qin (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Ong Minyee (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Ta Le Duc Huy (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Lau Hui Xing (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Tay Michelle Jia Yu (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Yap Qai Ven (Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Chan Yiong Huak (Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Tham Elizabeth Huiwen (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Tham Elizabeth Huiwen (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Tham Elizabeth Huiwen (Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Tham Elizabeth Huiwen (Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, Singapore) ,  Goh Anne Eng Neo (Allergy Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore) ,  Van Bever Hugo (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Van Bever Hugo (Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, Singapore) ,  Teoh Oon Hoe (Respiratory Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore) ,  Eriksson Johan Gunnar (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Eriksson Johan Gunnar (Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Eriksson Johan Gunnar (Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore) ,  Eriksson Johan Gunnar (Folkhaelsan Research Center, Faculty of Medicine, University of Helsinki, Helsinki, Finland) ,  Chong Yap Seng (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Chong Yap Seng (Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore) ,  Gluckman Peter (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Gluckman Peter (Liggins Institute, University of Auckland, Auckland, New Zealand) ,  Yap Fabian Kok Peng (Duke-NUS Medical School, Singapore, Singapore) ,  Yap Fabian Kok Peng (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore) ,  Yap Fabian Kok Peng (Endocrinology Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore) ,  Karnani Neerja (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Karnani Neerja (Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Karnani Neerja (Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore) ,  Xu Jia (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Tan Karen Mei Ling (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Tan Kok Hian (Department of Maternal Fetal Medicine, KK Women’s and Children’s Hospital, Singapore, Singapore) ,  Lee Bee Wah (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Kramer Michael (Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore) ,  Kramer Michael (Department of Pediatrics and of Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, QC, Canada) ,  Shek Lynette Pei-chi (Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore) ,  Shek Lynette Pei-chi (Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, Singapore) ,  Meaney Michael J. (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Meaney Michael J. (Sackler Program for Epigenetics & Psychobiology at McGill University, Montreal, QC, Canada) ,  Meaney Michael J. (Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada) ,  Meaney Michael J. (Department of Psychiatry, McGill University, Montreal, QC, Canada) ,  Broekman Birit F. P. (Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore) ,  Broekman Birit F. P. (Department of Psychiatry, OLVG and Amsterdam UMC, VU University, Amsterdam, Netherlands)
資料名： Frontiers in Pediatrics (Web)  (Frontiers in Pediatrics (Web))
巻： 10  ページ： 837741  発行年： 2022年 
JST資料番号： U7090A  ISSN： 2296-2360  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 背景:疫学研究は,湿疹と注意欠陥多動性障害(ADHD)の間のリンクを示唆するが,基礎となる機構は検討されていない。目的:著者らは,シンガポールにおける成長アップにおける湿疹とその後のADHD症状の間の関連を調査し,炎症誘発性サイトカインと腸ミクロビオームの役割を調査することを目的とする。【方法】小児版IVのための小児アンケートおよびコンピュータ化診断面接スケジュールにおける喘息およびアレルギーの修正国際研究を,それぞれ,最初の18か月以内の報告された湿疹および54か月におけるADHD症状の存在を評価するために施行した。18か月における皮膚プリック試験,妊娠中の母体血液中のサイトカインおよび臍帯血および24か月における腸ミクロビオームの仲介役割を評価した。結果:交絡因子を調整した後,陽性皮膚プリック試験有りまたは無しの湿疹はADHD症状のリスクを倍増した。母体と臍帯血サイトカインの差異は,湿疹の有無の子供,またはADHD有りと無しの子供で観察されなかった。湿疹とADHD児の子供では,腸内微生物叢異常症が観察された。湿疹の子供も,腸細菌Shannon多様性が低かった。しかしながら,湿疹とADHDの間の関係は,腸ミクロビオームにより仲介されなかった。結論:早期生活湿疹診断は,子供におけるその後のADHD症状のより高いリスクと関連している。炎症メカニズムの根底にある証拠はなく,腸ミクロビオーム異常症による仲介が見られなかった。更なる研究は,湿疹とADHDの間の関連の根底にある他の機構を評価するべきである。臨床試験登録:[],識別子[NCT01174875]。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 細菌 ,  アレルギー反応 ,  喘息 ,  妊娠 ,  臨床試験 ,  子供 ,  腸内微生物 ,  *湿疹 ,  疫学 ,  臍帯血 ,  サイトカイン ,  コンピュータ ,  炎症性サイトカイン
準シソーラス用語： 疫学研究 ,  母体 ,  常在菌叢ゲノム , 【Automatic Indexing@JST】

著者キーワード (5件)： アトピー ,  注意欠陥多動性障害 ,  サイトカイン ,  湿疹 ,  腸内マイクロビオーム性ジストロフィー症

分類 (1件)： 精神障害の診断  (GR02000T)

引用文献 (48件)：

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タイトルに関連する用語 (4件)： 小児 ,  湿疹 ,  注意欠陥多動性障害 ,  症状