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J-GLOBAL ID：202202263964870267   整理番号：22A1174106

寿命にわたる脳構造における長期的変化に関連する遺伝的変異【JST・京大機械翻訳】

Genetic variants associated with longitudinal changes in brain structure across the lifespan

著者 (120件)： Brouwer Rachel M. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Brouwer Rachel M. (Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands) ,  Klein Marieke (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Klein Marieke (Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA) ,  Klein Marieke (Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands) ,  Klein Marieke (Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands) ,  Grasby Katrina L. (Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia) ,  Schnack Hugo G. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Schnack Hugo G. (Utrecht Institute of Linguistics OTS, Utrecht University, Utrecht, The Netherlands) ,  Jahanshad Neda (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA) ,  Teeuw Jalmar (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Thomopoulos Sophia I. (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA) ,  Sprooten Emma (Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands) ,  Franz Carol E. (Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA) ,  Gogtay Nitin (American Psychiatric Association, Washington, DC, USA) ,  Kremen William S. (Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA) ,  Kremen William S. (VA San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA) ,  Panizzon Matthew S. (Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA) ,  Olde Loohuis Loes M. (Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA) ,  Whelan Christopher D. (Biogen Research and Development, Cambridge, MA, USA) ,  Aghajani Moji (Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands) ,  Aghajani Moji (Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden University, Leiden, The Netherlands) ,  Alloza Clara (Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Maranon, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Alnaes Dag (NORMENT Centre, University of Oslo, Oslo, Norway) ,  Alnaes Dag (Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway) ,  Artiges Eric (INSERM U1299 Trajectoires Developpementales en Psychiatrie, Ecole Normale Superieure Paris-Saclay, Universite Paris Saclay, Universite Paris Cite, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France) ,  Ayesa-Arriola Rosa (Valdecilla Biomedical Research Institute (IDIVAL), Marques de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain) ,  Ayesa-Arriola Rosa (CIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain) ,  Ayesa-Arriola Rosa (Universidad de Cantabria, Santander, Spain) ,  Barker Gareth J. (Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Bastin Mark E. (Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Bastin Mark E. (Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK) ,  Bastin Mark E. (Edinburgh Imaging, University of Edinburgh, Edinburgh, UK) ,  Blok Elisabet (Department of Child and Adolescent Psychiatry/Psychology, Sophia Children’s Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands) ,  Boen Erlend (Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway) ,  Breukelaar Isabella A. (Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia) ,  Bright Joanna K. (Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA) ,  Buimer Elizabeth E. L. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Buelow Robin (Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany) ,  Cannon Dara M. (Centre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland) ,  Ciufolini Simone (Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Crossley Nicolas A. (Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Crossley Nicolas A. (Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile) ,  Damatac Christienne G. (Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands) ,  Dazzan Paola (Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  de Mol Casper L. (Department of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands) ,  de Zwarte Sonja M. C. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Desrivieres Sylvane (Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Diaz-Caneja Covadonga M. (Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Maranon, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Doan Nhat Trung (NORMENT Centre, University of Oslo, Oslo, Norway) ,  Dohm Katharina (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Frohner Juliane H. (Section of Systems Neuroscience, Department of Psychiatry and Psychotherapy, Technische Universitaet Dresden, Dresden, Germany) ,  Goltermann Janik (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Grigis Antoine (Universite Paris-Saclay, CEA, Neurospin, Gif-sur-Yvette, France) ,  Grotegerd Dominik (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Han Laura K. M. (Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands) ,  Harris Mathew A. (Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Hartman Catharina A. (University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Groningen, The Netherlands) ,  Heany Sarah J. (Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa) ,  Heindel Walter (Clinic for Radiology, University Hospital Muenster, Muenster, Germany) ,  Heslenfeld Dirk J. (Departments of Experimental and Clinical Psychology, Amsterdam, The Netherlands) ,  Hohmann Sarah (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany) ,  Ittermann Bernd (Physikalisch-Technische Bundesanstalt, Berlin, Germany) ,  Jansen Philip R. (Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands) ,  Jansen Philip R. (Department of Child and Adolescent Psychiatry/Psychology, Sophia Children’s Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands) ,  Jansen Philip R. (Department of Human Genetics, VUmc, Amsterdam UMC, Amsterdam, The Netherlands) ,  Janssen Joost (Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Maranon, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain) ,  Jia Tianye (Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Science and Technology for Brain-Inspired Intelligence and MoE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China) ,  Jia Tianye (Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King’s College London, London, UK) ,  Jiang Jiyang (Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia) ,  Jockwitz Christiane (Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany) ,  Jockwitz Christiane (Institute for Anatomy I, Medical Faculty & University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany) ,  Karali Temmuz (Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany) ,  Karali Temmuz (NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, Munich, Germany) ,  Keeser Daniel (Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany) ,  Keeser Daniel (NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, Munich, Germany) ,  Keeser Daniel (Munich Center for Neurosciences (MCN) - Brain & Mind, Planegg-Martinsried, Germany) ,  Koevoets Martijn G. J. C. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Lenroot Rhoshel K. (School of Psychiatry, University of New South Wales, Sydney, NSW, Australia) ,  Lenroot Rhoshel K. (School of Psychiatry and Behavioral Sciences, School of Medicine, University of New Mexico, Albuquerque, NM, USA) ,  Lenroot Rhoshel K. (Neuroscience Research Australia, Sydney, NSW, Australia) ,  Malchow Berend (Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Gottingen, Germany) ,  Mandl Rene C. W. (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Medel Vicente (Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile) ,  Meinert Susanne (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Meinert Susanne (Institute for Translational Neuroscience, University of Muenster, Muenster, Germany) ,  Morgan Catherine A. ,  Morgan Catherine A. ,  Muehleisen Thomas W. (Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany) ,  Muehleisen Thomas W. ,  Muehleisen Thomas W. ,  Nabulsi Leila (Centre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland) ,  Opel Nils (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Opel Nils ,  de la Foz Victor Ortiz-Garcia (Valdecilla Biomedical Research Institute (IDIVAL), Marques de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain) ,  de la Foz Victor Ortiz-Garcia (CIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain) ,  de la Foz Victor Ortiz-Garcia ,  Overs Bronwyn J. (Neuroscience Research Australia, Sydney, NSW, Australia) ,  Paillere Martinot Marie-Laure (INSERM U1299 Trajectoires Developpementales en Psychiatrie, Ecole Normale Superieure Paris-Saclay, Universite Paris Saclay, Universite Paris Cite, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France) ,  Paillere Martinot Marie-Laure ,  Redlich Ronny (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Redlich Ronny ,  Marques Tiago Reis (Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK) ,  Marques Tiago Reis ,  Repple Jonathan (Institute for Translational Psychiatry, University of Muenster, Muenster, Germany) ,  Roberts Gloria (School of Psychiatry, University of New South Wales, Sydney, NSW, Australia) ,  Roshchupkin Gennady V. ,  Roshchupkin Gennady V. ,  Setiaman Nikita (Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands) ,  Setiaman Nikita (Department of Child and Adolescent Psychiatry/Psychology, Sophia Children’s Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands) ,  Shumskaya Elena (Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands) ,  Shumskaya Elena (Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands) ,  Stein Frederike ,  Sudre Gustavo ,  Takahashi Shun (Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany) ,  Takahashi Shun ,  Thalamuthu Anbupalam (Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia) ,  Tordesillas-Gutierrez Diana ,  Tordesillas-Gutierrez Diana ,  van der Lugt Aad
資料名： Nature Neuroscience  (Nature Neuroscience)
巻： 25  号： 4  ページ： 421-432  発行年： 2022年 
JST資料番号： W1370A  ISSN： 1097-6256  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： ヒト脳構造は寿命を通して変化する。変化した脳成長または低下率は,広範囲の精神,発達および神経変性疾患に関与する。本研究では,脳成長または萎縮率に影響する共通の遺伝的変異体を,著者らが知る限りにおいて,寿命にわたる脳形態の変化の最初のゲノムワイド関連メタアナリシスを同定した。15,640個体からの縦磁気共鳴映像データを用いて,15の脳構造の変化率を計算した。最も頑健に同定された遺伝子GPR139,DACH1およびAPOEは代謝過程と関連する。うつ病,統合失調症,認知機能,不眠,身長,ボディマスインデックスおよび喫煙とのグローバルな遺伝的重複を示した。遺伝子セット所見は,脳変化率における初期脳発達と神経変性過程の両方を意味する。構造的脳変化に関与する変異体の同定は,最適および機能障害の脳発達および加齢の根底にある生物学的経路の決定を助ける可能性がある。ヒト脳構造は寿命を通して変化する。Brouwerらは,脳の成長と萎縮率に影響する遺伝的変異を同定した。遺伝子は初期脳発達と神経変性に関連し,代謝過程の関与を示唆する。Copyright The Author(s), under exclusive licence to Springer Nature America, Inc. 2022 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *脳 ,  *遺伝 ,  遺伝子 ,  統合失調症 ,  ヒト ,  不眠 ,  神経系疾患 ,  うつ病 ,  機能障害 ,  萎縮症 ,  身長 ,  ボディマスインデックス ,  アポE
準シソーラス用語： 神経変性疾患 ,  神経変性 ,  *脳構造 , 【Automatic Indexing@JST】

分類 (1件)： 中枢神経系  (EJ12030F)

タイトルに関連する用語 (4件)： 寿命 ,  脳構造 ,  長期 ,  遺伝的変異