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J-GLOBAL ID：202202264388645314   整理番号：22A0567920

眼窩前頭皮質内のCircHomer1とHomer1b間の双方向競合相互作用は逆転学習を調節する【JST・京大機械翻訳】

A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning

著者 (44件)： Hafez Alexander K. (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Hafez Alexander K. (Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA) ,  Zimmerman Amber J. (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Papageorgiou Grigorios (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Chandrasekaran Jayapriya (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Amoah Stephen K. (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Amoah Stephen K. (Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA) ,  Lin Rixing (McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada) ,  Lozano Evelyn (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Pierotti Caroline (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Dell’Orco Michela (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Hartley Brigham J. (Pamela Sklar Division of Psychiatric Genomics, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Alural Beguem (Center for Genomic Medicine, Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Lalonde Jasmin (Center for Genomic Medicine, Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Esposito John Matthew (Translational Neuroscience Laboratory, Mclean Hospital, Belmont, MA, USA) ,  Berretta Sabina (Translational Neuroscience Laboratory, Mclean Hospital, Belmont, MA, USA) ,  Berretta Sabina (Department of Psychiatry, Harvard Medical School, Boston, MA, USA) ,  Berretta Sabina (Program in Neuroscience, Harvard Medical School, Boston, MA, USA) ,  Squassina Alessio (Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy) ,  Chillotti Caterina (Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy) ,  Voloudakis Georgios (Pamela Sklar Division of Psychiatric Genomics, New York, NY, USA) ,  Voloudakis Georgios (Department of Genetics and Genomic Sciences, New York, NY, USA) ,  Voloudakis Georgios (Icahn Institute for Data Science and Genomic Technology, New York, NY, USA) ,  Voloudakis Georgios (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Shao Zhiping (Pamela Sklar Division of Psychiatric Genomics, New York, NY, USA) ,  Shao Zhiping (Department of Genetics and Genomic Sciences, New York, NY, USA) ,  Shao Zhiping (Icahn Institute for Data Science and Genomic Technology, New York, NY, USA) ,  Fullard John F. (Pamela Sklar Division of Psychiatric Genomics, New York, NY, USA) ,  Fullard John F. (Department of Genetics and Genomic Sciences, New York, NY, USA) ,  Fullard John F. (Icahn Institute for Data Science and Genomic Technology, New York, NY, USA) ,  Brennand Kristen J. (Pamela Sklar Division of Psychiatric Genomics, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Turecki Gustavo (McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada) ,  Roussos Panos (Pamela Sklar Division of Psychiatric Genomics, New York, NY, USA) ,  Roussos Panos (Department of Genetics and Genomic Sciences, New York, NY, USA) ,  Roussos Panos (Icahn Institute for Data Science and Genomic Technology, New York, NY, USA) ,  Roussos Panos (Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Roussos Panos (Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY, USA) ,  Perlis Roy H. (Harvard Medical School, Department of Psychiatry, Boston, MA, USA) ,  Perlis Roy H. (Center for Experimental Drugs and Diagnostics, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA) ,  Haggarty Stephen J. (Center for Genomic Medicine, Chemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Perrone-Bizzozero Nora (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Brigman Jonathan L. (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Mellios Nikolaos (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA) ,  Mellios Nikolaos (Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA)
資料名： Cell Reports  (Cell Reports)
巻： 38  号： 3  ページ： Null  発行年： 2022年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 円形RNA(循環RNA)は脳に濃縮されているが,脳機能および精神疾患に対するそれらの関連性はよく理解されていない。ここでは,循環器1が,精神疾患を有する被験者の眼窩前頭皮質(OFC)と幹細胞由来ニューロン培養の両方で,相対的HOMER1B mRNAアイソ型レベルと逆相関することを示す。さらに,OFC内のin vivoサーキュマー1ノックダウン(KD)がHomer1b mRNAのシナプス発現を阻害することを示した。さらに,サーコHomer1はHomer1b mRNAと直接結合し,Homer1b特異的KDはシナプス循環Homemer1レベルを増加させ,OFC仲介行動柔軟性を改善することを示した。重要なことに,in vivo co-KDにおける二重循環Homer1とHomer1bは,機会反転学習とシナプス遺伝子発現の両方における循環Homemer1関連変化の完全な救済をもたらす。最後に,著者らは,サーキュマー1に直接結合し,その生合成を促進するRNA結合蛋白質を明らかにした。まとめると,著者らのデータは,脳機能および疾患における循環RNAの重要性に関する機構的洞察を提供する。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *相互作用 ,  ニューロン ,  生合成 ,  RNA【核酸】 ,  mRNA ,  シナプス ,  精神病 ,  柔軟性 ,  神経生理 ,  循環系 ,  幹細胞 ,  遺伝子発現 ,  RNA結合タンパク質
準シソーラス用語： 被験者 ,  遺伝子ノックダウン法 ,  脳機能 , 【Automatic Indexing@JST】

著者キーワード (7件)： サークRNA ,  CircHomer1 ,  Homer1 ,  OFC ,  双極性障害 ,  逆転学習 ,  認知柔軟性

分類 (1件)： 生物学的機能  (EB03040U)

タイトルに関連する用語 (6件)： 眼窩前頭皮質 ,  双方向 ,  競合 ,  相互作用 ,  逆転学習 ,  調節