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J-GLOBAL ID：202202265533504645   整理番号：22A0568895

自己組織化臨界より新たに生成されるDOCK8発現T濾胞ヘルパー細胞は全身性エリテマトーデスを引き起こす【JST・京大機械翻訳】

DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus

著者 (39件)： Shiozawa Shunichi (Institute for Rheumatic Diseases, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Shiozawa Shunichi (Department of Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan) ,  Shiozawa Shunichi (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Shiozawa Shunichi (Department of Medicine, Rheumatology and Orthopedic Surgery, Matsubara Mayflower Hospital, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Tsumiyama Ken (Institute for Rheumatic Diseases, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Tsumiyama Ken (Department of Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan) ,  Tsumiyama Ken (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Tsumiyama Ken (Department of Medicine, Rheumatology and Orthopedic Surgery, Matsubara Mayflower Hospital, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Miyazaki Yumi (Department of Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan) ,  Miyazaki Yumi (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Uto Kenichi (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Sakurai Keiichi (Institute for Rheumatic Diseases, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Sakurai Keiichi (Department of Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan) ,  Nakashima Toshie (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Matsuyama Hiroko (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Doi Ai (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Tarui Miho (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Izumikawa Manabu (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Kimura Mai (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Fujita Yuko (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Satonaka Chisako (Division of Bioregulation, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Sumaku, Kobe 654-0142, Japan) ,  Horiuchi Takahiko (Department of Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan) ,  Matsubara Tsukasa (Department of Medicine, Rheumatology and Orthopedic Surgery, Matsubara Mayflower Hospital, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Oribe Motohiro (Oribe Clinic, 1-8-15 Higashi-Odori, Oita 870-0823, Japan) ,  Yamane Takashi (Department of Rheumatology, Kakogawa City Hospital, 439 Honmachi, Kakogawa 675-8611, Japan) ,  Kagawa Hidetoshi (Department of Medicine, Red Cross Society Himeji Hospital, 1-12-1 Shimoteno, Himeji 670-8540, Japan) ,  Li Quan-Zhen (Department of Immunology, University of Texas Southwestern Medical Center, 6001 Forest Park Road/ND 6.504, Dallas, TX 75390-8814, USA) ,  Mizuno Keiko (Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojimaminamicho, Kobe 650-0047, Japan) ,  Mukai Yohei (Drug Discovery Platform, KAN Research Institute, Inc., 6-8-2 Minatojimaminamicho, Kobe 650-0047, Japan) ,  Murakami Kazuhiro (Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsujima, Aobaku 981-8558, Japan) ,  Enya Takuji (Department of Immunology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Enya Takuji (Department of Pediatrics, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Tsukimoto Shota (Department of Immunology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Tsukimoto Shota (Department of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Hakata Yoshiyuki (Department of Immunology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Miyazawa Masaaki (Department of Immunology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan) ,  Miyazawa Masaaki (Kindai University Anti-Aging Center, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan) ,  Shiozawa Kazuko (Department of Medicine, Rheumatology and Orthopedic Surgery, Matsubara Mayflower Hospital, 944-25 Fujita, Katoshi 673-1462, Japan) ,  Shiozawa Kazuko (Rheumatology and Collagen Disease Center, Hyogo Prefectural Kakogawa Medical Center, 203 Kanno, Kakogawa 675-8555, Japan)
資料名： iScience  (iScience)
巻： 25  号： 1  ページ： Null  発行年： 2022年 
JST資料番号： W5512A  ISSN： 2589-0042  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 自己抗原を含む病原体は全て全身性エリテマトーデス(SLE)を誘導しなかった。代わりに,病原体を認識する宿主免疫応答の完全性を研究した。宿主の定常状態応答,自己組織化臨界性を超えるレベルに反復する抗原によるTCRの刺激により,細胞表面上のグアニンヌクレオチド交換因子DOCK8を発現するT濾胞ヘルパー(Tfh)細胞が新しく生成された。DOCK8+Tfh細胞は,TCR再訪問を通過し,自己抗体およびループス病変を誘発した。それらは,活性ループス患者の脾臓赤髄と末梢血に存在し,その後,治療後に低下した。自己抗体と疾患は,SLEモデル(NZBxNZW)F1マウスを含むマウスで抗DOCK8抗体により治癒した。このように,外因性または内因性のどちらかの病原体の免疫原性型による反復TCR刺激後に発生したDOCK8+Tfh細胞は,HLAとの組み合わせで,システムの自己組織化臨界性を超え,SLEを引き起こす。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 抗原 ,  抗体 ,  *細胞 ,  脾臓 ,  マウス ,  免疫反応 ,  *卵胞 ,  病原体 ,  *ヘルパーT細胞 ,  自己抗体 ,  *全身性エリテマトーデス ,  自己抗原 ,  末梢血
準シソーラス用語： 細胞表面 ,  濾胞ヘルパーT細胞 , 【Automatic Indexing@JST】

著者キーワード (3件)： 免疫学 ,  免疫応答 ,  細胞生物学

分類 (2件)： 免疫性疾患・アレルギー性疾患一般  (GD04010C) ,  免疫反応一般  (ED03010T)

タイトルに関連する用語 (5件)： 自己組織化臨界 ,  発現 ,  濾胞 ,  ヘルパー細胞 ,  全身性エリテマトーデス