文献

J-GLOBAL ID：202202268985344452   整理番号：22A1179041

糞便におけるSARS-CoV-2陽性を有するCOVID-19患者の特徴【JST・京大機械翻訳】

Characteristics of COVID-19 Patients With SARS-CoV-2 Positivity in Feces

著者 (25件)： Wu Wenrui (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Wu Wenrui (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Wu Wenrui (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Shi Ding (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Shi Ding (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Shi Ding (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Zhu Xueling (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Zhu Xueling (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Zhu Xueling (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xie Jiaojiao (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xie Jiaojiao (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xie Jiaojiao (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xu Xinyi (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xu Xinyi (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Xu Xinyi (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Chen Yanfei (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Chen Yanfei (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Chen Yanfei (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Wu Jingjing (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Wu Jingjing (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Wu Jingjing (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Li Lanjuan (1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Li Lanjuan (2National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Li Lanjuan (3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China) ,  Li Lanjuan (4Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China)
資料名： Frontiers in Cellular and Infection Microbiology (Web)  (Frontiers in Cellular and Infection Microbiology (Web))
巻： 12  ページ： 853212  発行年： 2022年 
JST資料番号： U7063A  ISSN： 2235-2988  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 背景:SARS-CoV-2は高度に伝染性であり,流行制御と予防に大きな脅威をもたらす。糞便-経口伝染の可能性は,懸念を引きつけた。しかし,糞便中のウイルス放出は完全には研究されていない。方法:本研究は,197年1月19日から2月17日まで,浙江省大学,第1回付属病院に入院した97の確認されたコロナウイルス病2019(COVID-19)患者を遡及的にレビューした。喀痰,鼻咽頭または咽頭スワブ,気管支肺胞洗浄および糞便のサンプルにおけるSARS-CoV-2RNAを,リアルタイム逆転写ポリメラーゼ連鎖反応(RT-PCR)によって検出した。糞便RNAが陽性であるかどうかを決定するために,臨床的特徴とパラメータを群間で比較した。結果:患者の34(35.1%)は,糞便において検出可能なSARS-CoV-2RNAを示し,63(64.9%)は陰性検出結果を示した。糞便中のウイルス放出の中央値は約25日であり,最大時間は33日であった。長期の糞便-洗浄患者は,より長い病院滞在を示した。糞便ウイルス陽性が3週間以上持続した患者は,非延長群[70.5(47.3~121.5)/μL対186.5(129.3~376.0)/μL,P=0.023]の患者より血漿B細胞数が低かった。相関分析は,糞便放出の期間が呼吸ウイルス放出の期間と正相関し(R=0.70,P<0.001),末梢B細胞数と負相関した(R=-0.44,P<0.05)。結論:糞便中にSARS-CoV-2 RNAを排出するCOVID-19患者は,糞便中にSARS-CoV-2 RNAを排出しなかった患者と同様の臨床的特徴と転帰を示した。糞便中のSARS-CoV-2核酸の持続的存在は,気道におけるSARS-CoV-2 RNAの延長放出と,低い血漿B細胞数と高度に相関した。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 血漿 ,  ウイルス ,  RNA【核酸】 ,  咽頭 ,  気道 ,  *糞便 ,  生体試料 ,  感染 ,  *コロナウイルス科 ,  喀痰 ,  順相
準シソーラス用語： 鼻咽頭 ,  コロナウイルス ,  *SARSウイルス ,  *重症急性呼吸器症候群 ,  ウイルス放出 ,  スワブ , 【Automatic Indexing@JST】

著者キーワード (5件)： SARS-CoV-2 ,  糞便-口腔伝達 ,  リンパ球 ,  ウイルス排出 ,  COVID-19

分類 (3件)： ウイルス学一般  (EG04010J) ,  ウイルスによる動物の伝染病  (FE02024R) ,  微生物検査法  (EG02020G)

引用文献 (46件)：

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タイトルに関連する用語 (4件)： 糞便 ,  SARS-CoV-2 ,  COVID-19 ,  患者