文献

J-GLOBAL ID：202202276737226281   整理番号：22A0751545

ALDH(rs671)の遺伝的変異は中国漢民族におけるHBV感染の持続性と関連する【JST・京大機械翻訳】

Genetic Variations of ALDH (rs671) Are Associated With the Persistence of HBV Infection Among the Chinese Han Population

著者 (26件)： Shang Dabao (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Shang Dabao (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Peng (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Peng (Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China) ,  Tang Weiliang (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Tang Weiliang (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Mo Ruidong (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Mo Ruidong (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Lai Rongtao (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Lai Rongtao (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Lu Jie (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Lu Jie (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Li Ziqiang (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Li Ziqiang (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Xiaolin (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Xiaolin (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Cai Wei (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Cai Wei (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Hui (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Hui (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Zhao Gangde (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Zhao Gangde (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Xie Qing (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Xie Qing (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Xiang Xiaogang (Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Xiang Xiaogang (Translational Laboratory of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China)
資料名： Frontiers in Medicine (Web)  (Frontiers in Medicine (Web))
巻： 9  ページ： 811639  発行年： 2022年 
JST資料番号： U7079A  ISSN： 2296-858X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： アルコールデヒドロゲナーゼファミリーであるアルコールデヒドロゲナーゼ1B(ADH1B)とアルデヒドデヒドロゲナーゼ2(ALDH2)は,肝臓疾患において重要な役割を持つ。本研究では,B型肝炎ウイルス(HBV)感受性および持続性感染におけるADH1B rs1229984およびALDH2 rs671の多型の役割を検討した。B型肝炎[99の急性B型肝炎(AHB),521の慢性B型肝炎(CHB),159の急性-慢性肝不全(ACLF),159の肝硬変(LC),および97の肝細胞癌(HCC)],および1262の肝細胞癌(HCC),およびrs671とrs1229984の単一ヌクレオチド多型(HC)を遺伝子型決定して,遺伝子型を遺伝子型決定した,合計1,034人の患者を,募集した。そして,rs671とrs1229984の一塩基多型(SNP)を,遺伝子型を分類した,そして,rs671とrs1229984の一塩基多型(SNP)を,遺伝子型決定した。HBV感染におけるrs671とrs1229984の独立と関節の役割を分析した。結果は,rs671遺伝子型が異なるサブグループ間で有意に異なる分布を持つことを示した。HCと比較して,rs671-AA遺伝子型の頻度は,特にCHB群[調整OR(95%CI)=1.899(1.232-2.928),p=0.003,共優性モデル]で高く,有意な正相関を示した。さらに,ALDH2 rs671-AA遺伝子型を有するCHB個体は,GG/GA遺伝子型のそれらと比較して,持続性HBV感染のより高いリスクおよびより高いHBV-DNA定量を有することを確認した。さらに,rs671-AA遺伝子型はCHB患者におけるHCC発生率を予測する可能性がある。HCと比較して,AHB,ACLF,LC,またはHCC群のrs671変異体における対立遺伝子または遺伝子型の異なる分布はなかった。これらのデータは,HBV感染と持続性におけるrs671-AA変異体の有害な役割を示唆した。Copyright 2022 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： アルコールデヒドロゲナーゼ ,  *遺伝子型 ,  肝硬変 ,  突然変異体 ,  対立遺伝子 ,  B型肝炎ウイルス ,  優性 ,  順相 ,  B型肝炎 ,  肝細胞癌 ,  B型慢性肝炎 ,  一塩基多型
準シソーラス用語： 急性B型肝炎 ,  遺伝子タイピング ,  *B型肝炎ウイルス感染 , 【Automatic Indexing@JST】

著者キーワード (5件)： HBV ,  rs671 ,  ALDH ,  多型 ,  関連研究

分類 (3件)： 感染症・寄生虫症一般  (GD01010H) ,  消化器の腫よう  (GH04000D) ,  消化器の疾患  (GH03000W)

引用文献 (31件)：

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タイトルに関連する用語 (5件)： 遺伝的変異 ,  中国 ,  民族 ,  HBV感染 ,  持続性