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J-GLOBAL ID：202202277176099669   整理番号：22A0838870

再ワイヤ化グリコシル化活性は完全な脊髄離断後のSpinyマウスにおける無瘢痕再生と機能的回復を促進する【JST・京大機械翻訳】

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

著者 (39件)： Nogueira-Rodrigues Joana (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Nogueira-Rodrigues Joana (Graduate Program in Molecular and Cell Biology, Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal) ,  Leite Sergio C. (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Pinto-Costa Rita (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Sousa Sara C. (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Sousa Sara C. (Graduate Program in Molecular and Cell Biology, Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal) ,  Luz Liliana L. (Neuronal Networks Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Sintra Maria A. (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Oliveira Raquel (Translational NeuroUrology Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Oliveira Raquel (Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal) ,  Oliveira Raquel (Regeneration Group, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, King’s College London WC2R 2LS, London, UK) ,  Monteiro Ana C. (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Pinheiro Goncalo G. (Molecular & Regenerative Medicine Laboratory, Centro de Ciencias do Mar (CCMAR), University of Algarve, 8005-139 Faro, Portugal) ,  Pinheiro Goncalo G. (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Vitorino Marta (Molecular & Regenerative Medicine Laboratory, Centro de Ciencias do Mar (CCMAR), University of Algarve, 8005-139 Faro, Portugal) ,  Vitorino Marta (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Silva Joana A. (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Simao Sonia (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Simao Sonia (Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, 8005-139 Faro, Portugal) ,  Fernandes Vitor E. (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Fernandes Vitor E. (Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, 8005-139 Faro, Portugal) ,  Provaznik Jan (Genomics Core Facility, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany) ,  Benes Vladimir (Genomics Core Facility, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany) ,  Cruz Celia D. (Translational NeuroUrology Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Cruz Celia D. (Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal) ,  Safronov Boris V. (Neuronal Networks Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Magalhaes Ana (Glycobiology in Cancer Group, Institute of Molecular Pathology and Immunology, IPATIMUP, Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Magalhaes Ana (Department of Molecular Biology, Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal) ,  Reis Celso A. (Glycobiology in Cancer Group, Institute of Molecular Pathology and Immunology, IPATIMUP, Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Reis Celso A. (Department of Molecular Biology, Instituto de Ciencias Biomedicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal) ,  Reis Celso A. (Department of Pathology, Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal) ,  Vieira Jorge (Phenotypic Evolution Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Vieira Cristina P. (Phenotypic Evolution Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal) ,  Tiscornia Gustavo (Molecular & Regenerative Medicine Laboratory, Centro de Ciencias do Mar (CCMAR), University of Algarve, 8005-139 Faro, Portugal) ,  Tiscornia Gustavo (Clinica Eugin, Research and Development, 08006 Barcelona, Spain) ,  Araujo Ines M. (Faculty of Medicine and Biomedical Sciences, University of Algarve, 8005-139 Faro, Portugal) ,  Araujo Ines M. (Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, 8005-139 Faro, Portugal) ,  Araujo Ines M. (Champalimaud Research Program, Champalimaud Center for the Unknown, 1400-038 Lisbon, Portugal) ,  Sousa Monica M. (Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigacao e Inovacao em Saude (i3S), University of Porto, 4200-135 Porto, Portugal)
資料名： Developmental Cell  (Developmental Cell)
巻： 57  号： 4  ページ： 440-450.e7  発行年： 2022年 
JST資料番号： W1692A  ISSN： 1534-5807  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 成体哺乳類中枢神経系(CNS)軸索の再生は,脊髄損傷(SCI)を含むCNS病変後の機能を回復することができない。ここでは,棘状マウス(Acomys)が他の哺乳類の例外であり,重度のSCI後の機能の自然で迅速な回復が可能であり,後肢協調を再確立できることを示した。注目すべきことに,Acomysは損傷部位で瘢痕のない前再生組織を集合し,初期脊髄構造のユニークな構造連続性を提供する。Acomys SCI部位は,複数の路,シナプス形成,および電気生理学的シグナル伝播の強固な軸索再生を示す。トランスクリプトーム再構築後の脊髄のトランスクリプトーム解析により,Acomysはグリコシル化生合成経路を再構築し,SCI部位で特異的なプロ再生プロテオグリカンシグネチャーに終わることが明らかになった。この研究は,グリコシル化スイッチがSCI後の軸索再生に重要であることを明らかにし,軸索成長のエンハンサーとして,ケラタン硫酸生合成の重要な酵素であるβ3gnt7を同定した。Copyright 2022 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 酵素 ,  生合成 ,  軸索 ,  *脊髄 ,  哺乳類 ,  形態形成 ,  成体 ,  プロテオグリカン ,  *グリコシル化 ,  ロバスト性 ,  *瘢痕 ,  脊髄損傷 ,  シナプス形成 ,  トランスクリプトーム
準シソーラス用語： 軸索再生 ,  軸索成長 , 【Automatic Indexing@JST】

著者キーワード (10件)： アセチルグルコサミニルトランスフェラーゼ ,  Acomys cahirinus ,  軸索再生 ,  線維性瘢痕 ,  グリア瘢痕 ,  グリコサミノグリカン ,  グリコシル化 ,  プロテオグリカン ,  脊髄損傷 ,  Spinyマウス

分類 (3件)： 生物学的機能  (EB03040U) ,  発生と分化  (EJ16020W) ,  中枢神経系  (EJ12030F)

タイトルに関連する用語 (8件)： ワイヤ ,  グリコシル化 ,  活性 ,  脊髄 ,  マウス ,  瘢痕 ,  回復 ,  促進