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J-GLOBAL ID：202202278694452241   整理番号：22A0952107

上部臨界溶液温度多価足場凝集体と細菌【JST・京大機械翻訳】

Upper Critical Solution Temperature Polyvalent Scaffolds Aggregate and Exterminate Bacteria

著者 (25件)： Chen Kai-Feng (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Chen Kai-Feng (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Zhang Yiqing (Department of Cell Biology, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Southern Medical University, Guangzhou, 510515, China) ,  Lin Jiawei (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Lin Jiawei (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Chen Jun-You (Department of Cell Biology, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Southern Medical University, Guangzhou, 510515, China) ,  Lin Caihong (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Lin Caihong (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Gao Meng (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Gao Meng (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Chen Yunhua (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Chen Yunhua (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Liu Sa (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Liu Sa (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Wang Lin (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Wang Lin (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Wang Lin (Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China) ,  Wang Lin (Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, China) ,  Wang Lin (Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Cui Zhong-Kai (Department of Cell Biology, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Southern Medical University, Guangzhou, 510515, China) ,  Jia Yong-Guang (School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China) ,  Jia Yong-Guang (National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China) ,  Jia Yong-Guang (Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China) ,  Jia Yong-Guang (Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, China) ,  Jia Yong-Guang (Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China)
資料名： Small  (Small)
巻： 18  号： 11  ページ： e2107374  発行年： 2022年 
JST資料番号： W2348A  ISSN： 1613-6810  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 宿主細胞複合糖質と細菌受容体の特異的認識と強い親和性は,細菌凝集と殺菌細菌を制御する道を開く。ここでは,凝集誘導発光(AIE)分子修飾上部臨界溶液温度(UCST)多価足場(PATC-GlcN)を用いて,細菌凝集を可視化し,温度刺激下で細菌-多価足場親和性を制御する方法について述べた。ジブロックを有する多価足場,鋭いUCST転移を示すポリアクリルアミドの1つのUCSTブロックPATCおよび典型的なAIE挙動,親水性グルコサミン修飾ポリアクリルアミドの第二細菌認識ブロックGlcNを,可逆的付加およびフラグメンテーション連鎖移動重合により調製した。UCST以下の温度での多価足場の凝集鎖立体配座は,グルコサミン部分の高密度のため,大腸菌ATCC8739の凝集を誘導し,一方,UCSTを越えて,足場の親水性状態は,細菌凝集を解離した。多価足場に対する細菌の甘味は,同時に蛍光イメージング技術により可視化できる。細菌による多価足場の特異的な認識のため,光熱剤IR780負荷PATC-GlcNは,in vitroで大腸菌ATCC8739に対する標的殺傷能力を示し,NIR照射下でin vivoであった。Copyright 2022 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *凝集 ,  立体配座 ,  殺菌 ,  *細菌 ,  大腸菌 ,  重合 ,  親水性 ,  ポリアクリルアミド ,  可視化 ,  フラグメンテーション ,  in vitro実験 ,  複合糖質 ,  *凝集体 ,  ヘキソサミン
準シソーラス用語： 蛍光イメージング , 【Automatic Indexing@JST】

著者キーワード (5件)： 凝集誘起発光 ,  細菌凝集 ,  多価足場 ,  標的殺菌細菌 ,  上部臨界溶解温度

分類 (5件)： 滅菌法  (EG02040C) ,  診断用薬の基礎研究  (GW20010P) ,  分析機器  (CC02020S) ,  薬剤学一般  (GY01011J) ,  脂質一般  (EB05010B)

物質索引 (1件)： グルコサミン

タイトルに関連する用語 (5件)： 臨界溶液温度 ,  多価 ,  足場 ,  凝集体 ,  細菌