文献

J-GLOBAL ID：202202278803682053   整理番号：22A1039030

神経変性疾患における潜在的薬物としての食事植物ポリフェノール:現在のエビデンス,進歩および機会【JST・京大機械翻訳】

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

著者 (19件)： Yan Lu (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Guo Min-Song (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Zhang Yue (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Yu Lu (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Wu Jian-Ming (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Tang Yong (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Tang Yong (State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China) ,  Ai Wei (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Zhu Feng-Dan (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Law Betty Yuen-Kwan (State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China) ,  Chen Qi (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Chen Qi (Department of Nursing, Affiliated Hospital of Southwest Medical University, Luzhou, China) ,  Yu Chong-Lin (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Wong Vincent Kam-Wai (State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China) ,  Li Hua (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Li Mao (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Zhou Xiao-Gang (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...) ,  Qin Da-Lian (State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China) ,  Wu An-Guo (Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, College of Preclinical ...)
資料名： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Medicine and Cellular Longevity (Web))
巻： 2022  ページ： Null  発行年： 2022年 
JST資料番号： U7012A  ISSN： 1942-0900  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： Alzheimer病(AD),パーキンソン病(PD),およびHuntington病(HD)を含む神経変性疾患は,ニューロンの進行性変性を特徴とする。神経変性疾患の病因と病因は集中的に研究されているが,その機序はまだその幼児期にある。一般的に,ほとんどの神経変性疾患は共通の分子機構を共有し,複数のリスクは神経発生疾患の病理学的過程を促進し促進する。現在,承認された薬剤の大部分は臨床症状を軽減するが,神経変性疾患を治癒できない。多くの研究は,食餌性植物ポリフェノールが安全で,様々な神経変性疾患において強力な神経保護効果を示すことを示している。しかし,低いバイオアベイラビリティはポリフェノールに対する最大の障害であり,臨床診療への証拠からその採用を大きく制限する。本レビューでは,誤折畳み蛋白質,ミトコンドリア機能障害,酸化損傷および神経炎症応答のような神経変性疾患に関連する広く認識されたメカニズムを要約した。さらに,最も広く報告された食事植物ポリフェノールの神経保護効果に関する研究進展を要約した。さらに,著者らは,血液-脳関門(BBB)を横断して低い安定性および低い透過性のような低いバイオアベイラビリティをもたらすポリフェノールおよび因子の現在の臨床研究および応用を議論した。将来,吸収と安定性の改善,構造と製剤の改良,および併用療法は,ポリフェノールのための臨床検査室からより多くの機会を提供する。最後に,本レビューは神経変性疾患の治療における天然食事ポリフェノールに関するさらなる研究を促進することが期待される。Copyright 2022 Lu Yan et al. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ニューロン ,  タンパク質 ,  *病気 ,  折畳み ,  *神経系疾患 ,  *多価フェノール ,  機能障害 ,  バイオアベイラビリティ ,  併用療法 ,  Alzheimer病 ,  Parkinson病 ,  病因 ,  ミトコンドリア病 ,  Huntington病
準シソーラス用語： *神経変性疾患 ,  分子機構 ,  炎症反応 ,  ミトコンドリア機能障害 , 【Automatic Indexing@JST】

分類 (2件)： その他の中枢神経系作用薬の基礎研究  (GW03120U) ,  神経の基礎医学  (GN01020W)

引用文献 (456件)：

• M. Golpich, E. Amini, Z. Mohamed, R. Azman Ali, N. Mohamed Ibrahim, A. Ahmadiani, "Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment," CNS Neuroscience & Therapeutics, vol. 23, no. 1, pp. 5-22, 2017.
• S. Kausar, F. Wang, H. Cui, "The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases," Cell, vol. 7, no. 12, pp. 274, 2018.
• K. A. Jellinger, "Basic mechanisms of neurodegeneration: a critical update," Journal of Cellular and Molecular Medicine, vol. 14, no. 3, pp. 457-487, 2010.
• E. Bossy-Wetzel, R. Schwarzenbacher, S. A. Lipton, "Molecular pathways to neurodegeneration," Nature Medicine, vol. 10, no. S7, pp. S2-S9, 2004.
• C. Wells, S. E. Brennan, M. Keon, N. K. Saksena, "Prionoid proteins in the pathogenesis of neurodegenerative diseases," Frontiers in Molecular Neuroscience, vol. 12, 2019.

タイトルに関連する用語 (6件)： 神経変性疾患 ,  薬物 ,  食事 ,  植物ポリフェノール ,  エビデンス ,  機会